Odor Memory Stability after Reinnervation of the Olfactory Bulb

Eduardo Blanco-Hernández, Pablo Valle-Leija, Viviana Zomosa-Signoret, René Drucker-Colín, Román Vidaltamayo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice. This anatomical regeneration correlates with functional recovery of a previously learned odorant-discrimination task, dependent on the cognate ligands for M72 and I7. Following regeneration, mice also recover innate responsiveness to TMT and urine. Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain. © 2012 Blanco-Hernández et al.
Original languageEnglish
JournalPLoS One
DOIs
Publication statusPublished - 10 Oct 2012

Fingerprint

Methimazole
olfactory bulb
Olfactory Bulb
Odors
Regeneration
Brain
odors
brain
Data storage equipment
Recovery
Networks (circuits)
sensory neurons
mice
odor compounds
Olfactory Receptor Neurons
lesions (animal)
bulbs
Neurons
Olfactory Mucosa
Aptitude

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Blanco-Hernández, E., Valle-Leija, P., Zomosa-Signoret, V., Drucker-Colín, R., & Vidaltamayo, R. (2012). Odor Memory Stability after Reinnervation of the Olfactory Bulb. PLoS One. https://doi.org/10.1371/journal.pone.0046338
Blanco-Hernández, Eduardo ; Valle-Leija, Pablo ; Zomosa-Signoret, Viviana ; Drucker-Colín, René ; Vidaltamayo, Román. / Odor Memory Stability after Reinnervation of the Olfactory Bulb. In: PLoS One. 2012.
@article{7647bb6520034510b6a9d559e9666e81,
title = "Odor Memory Stability after Reinnervation of the Olfactory Bulb",
abstract = "The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice. This anatomical regeneration correlates with functional recovery of a previously learned odorant-discrimination task, dependent on the cognate ligands for M72 and I7. Following regeneration, mice also recover innate responsiveness to TMT and urine. Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain. {\circledC} 2012 Blanco-Hern{\'a}ndez et al.",
author = "Eduardo Blanco-Hern{\'a}ndez and Pablo Valle-Leija and Viviana Zomosa-Signoret and Ren{\'e} Drucker-Col{\'i}n and Rom{\'a}n Vidaltamayo",
year = "2012",
month = "10",
day = "10",
doi = "10.1371/journal.pone.0046338",
language = "English",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",

}

Blanco-Hernández, E, Valle-Leija, P, Zomosa-Signoret, V, Drucker-Colín, R & Vidaltamayo, R 2012, 'Odor Memory Stability after Reinnervation of the Olfactory Bulb', PLoS One. https://doi.org/10.1371/journal.pone.0046338

Odor Memory Stability after Reinnervation of the Olfactory Bulb. / Blanco-Hernández, Eduardo; Valle-Leija, Pablo; Zomosa-Signoret, Viviana; Drucker-Colín, René; Vidaltamayo, Román.

In: PLoS One, 10.10.2012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Odor Memory Stability after Reinnervation of the Olfactory Bulb

AU - Blanco-Hernández, Eduardo

AU - Valle-Leija, Pablo

AU - Zomosa-Signoret, Viviana

AU - Drucker-Colín, René

AU - Vidaltamayo, Román

PY - 2012/10/10

Y1 - 2012/10/10

N2 - The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice. This anatomical regeneration correlates with functional recovery of a previously learned odorant-discrimination task, dependent on the cognate ligands for M72 and I7. Following regeneration, mice also recover innate responsiveness to TMT and urine. Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain. © 2012 Blanco-Hernández et al.

AB - The olfactory system, particularly the olfactory epithelium, presents a unique opportunity to study the regenerative capabilities of the brain, because of its ability to recover after damage. In this study, we ablated olfactory sensory neurons with methimazole and followed the anatomical and functional recovery of circuits expressing genetic markers for I7 and M72 receptors (M72-IRES-tau-LacZ and I7-IRES-tau-GFP). Our results show that 45 days after methimazole-induced lesion, axonal projections to the bulb of M72 and I7 populations are largely reestablished. Furthermore, regenerated glomeruli are re-formed within the same areas as those of control, unexposed mice. This anatomical regeneration correlates with functional recovery of a previously learned odorant-discrimination task, dependent on the cognate ligands for M72 and I7. Following regeneration, mice also recover innate responsiveness to TMT and urine. Our findings show that regeneration of neuronal circuits in the olfactory system can be achieved with remarkable precision and underscore the importance of glomerular organization to evoke memory traces stored in the brain. © 2012 Blanco-Hernández et al.

U2 - 10.1371/journal.pone.0046338

DO - 10.1371/journal.pone.0046338

M3 - Article

JO - PLoS One

JF - PLoS One

SN - 1932-6203

ER -

Blanco-Hernández E, Valle-Leija P, Zomosa-Signoret V, Drucker-Colín R, Vidaltamayo R. Odor Memory Stability after Reinnervation of the Olfactory Bulb. PLoS One. 2012 Oct 10. https://doi.org/10.1371/journal.pone.0046338