Obesity, Thrombotic Risk, and Inflammation in Cancer

Benjamín Rubio-Jurado, Luz-Ma-Adriana Balderas-Peña, Eduardo E. García-Luna, María G. Zavala-Cerna, Carlos Riebeling-Navarro, Pedro A. Reyes, Arnulfo H. Nava-Zavala

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~ 20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia. Cancer-associated hypercoagulable and thrombotic states are influenced by abnormalities in the vascular wall and susceptibility to invasion, interference in blood flow and increase in circulating tissue factor and thrombin, activation of cell growth factors, the presence of a central catheter, chemotherapies, neoplasm type, and surgery. In cancer, thromboembolic complications are the second most frequent cause of death with pulmonary thromboembolism in ~ 50% of cases postmortem. Thrombosis worsens prognosis as demonstrated with a survival rate as low as 12% per year vs 36% in nonthrombic patients. Deep vein thrombosis is the most frequent thromboembolic complication in cancer. It is usually detected at diagnosis and within the first 3 months of chemotherapy. The underlining mechanisms of this association should be further studied to identify patients at higher risk and develop adequate prevention, diagnostic, and treatment measures. The D-dimer test can be successfully used to assess the fibrinolytic phase of coagulation and as such is routinely used in suspected cases of deep vein thrombosis and pulmonary thromboembolism. In addition, significant advances have been made in understanding the composition and functional capabilities of the gut microbiota in the inflammatory process, obesity, and its roles in cancer; however, the intricate balance that exists within the microbiota may not only affect the host directly, it can also disrupt the entire microbial community. Conclusions: Cancer is a prothrombotic and inflammatory state in which the activation of coagulation is related to tumor growth, angiogenesis, and metastasis. It is important to identify the relationship between body mass index with these processes and clarify their importance in cancer prognosis. Future research should answer the question if manipulation of resident microbial communities could potentially improve prognosis and treatment outcome.

Original languageEnglish
Title of host publicationAdvances in Clinical Chemistry
EditorsGregory S. Makowski
Pages71-89
Number of pages19
Volume85
DOIs
Publication statusPublished - 2018

Publication series

NameAdvances in Clinical Chemistry
Volume85
ISSN (Print)0065-2423

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Chemotherapy
Coagulation
Obesity
Chemical activation
Inflammation
Adipokines
Catheters
Cell growth
Thromboplastin
Somatomedins
Thrombin
Surgery
Tumors
Neoplasms
Intercellular Signaling Peptides and Proteins
Blood
Association reactions
Hormones
Insulin
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Clinical Biochemistry

Cite this

Rubio-Jurado, B., Balderas-Peña, L-M-A., García-Luna, E. E., Zavala-Cerna, M. G., Riebeling-Navarro, C., Reyes, P. A., & Nava-Zavala, A. H. (2018). Obesity, Thrombotic Risk, and Inflammation in Cancer. In G. S. Makowski (Ed.), Advances in Clinical Chemistry (Vol. 85, pp. 71-89). (Advances in Clinical Chemistry; Vol. 85). https://doi.org/10.1016/bs.acc.2018.02.006
Rubio-Jurado, Benjamín ; Balderas-Peña, Luz-Ma-Adriana ; García-Luna, Eduardo E. ; Zavala-Cerna, María G. ; Riebeling-Navarro, Carlos ; Reyes, Pedro A. ; Nava-Zavala, Arnulfo H. / Obesity, Thrombotic Risk, and Inflammation in Cancer. Advances in Clinical Chemistry. editor / Gregory S. Makowski. Vol. 85 2018. pp. 71-89 (Advances in Clinical Chemistry).
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abstract = "Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~ 20{\%} of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia. Cancer-associated hypercoagulable and thrombotic states are influenced by abnormalities in the vascular wall and susceptibility to invasion, interference in blood flow and increase in circulating tissue factor and thrombin, activation of cell growth factors, the presence of a central catheter, chemotherapies, neoplasm type, and surgery. In cancer, thromboembolic complications are the second most frequent cause of death with pulmonary thromboembolism in ~ 50{\%} of cases postmortem. Thrombosis worsens prognosis as demonstrated with a survival rate as low as 12{\%} per year vs 36{\%} in nonthrombic patients. Deep vein thrombosis is the most frequent thromboembolic complication in cancer. It is usually detected at diagnosis and within the first 3 months of chemotherapy. The underlining mechanisms of this association should be further studied to identify patients at higher risk and develop adequate prevention, diagnostic, and treatment measures. The D-dimer test can be successfully used to assess the fibrinolytic phase of coagulation and as such is routinely used in suspected cases of deep vein thrombosis and pulmonary thromboembolism. In addition, significant advances have been made in understanding the composition and functional capabilities of the gut microbiota in the inflammatory process, obesity, and its roles in cancer; however, the intricate balance that exists within the microbiota may not only affect the host directly, it can also disrupt the entire microbial community. Conclusions: Cancer is a prothrombotic and inflammatory state in which the activation of coagulation is related to tumor growth, angiogenesis, and metastasis. It is important to identify the relationship between body mass index with these processes and clarify their importance in cancer prognosis. Future research should answer the question if manipulation of resident microbial communities could potentially improve prognosis and treatment outcome.",
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Rubio-Jurado, B, Balderas-Peña, L-M-A, García-Luna, EE, Zavala-Cerna, MG, Riebeling-Navarro, C, Reyes, PA & Nava-Zavala, AH 2018, Obesity, Thrombotic Risk, and Inflammation in Cancer. in GS Makowski (ed.), Advances in Clinical Chemistry. vol. 85, Advances in Clinical Chemistry, vol. 85, pp. 71-89. https://doi.org/10.1016/bs.acc.2018.02.006

Obesity, Thrombotic Risk, and Inflammation in Cancer. / Rubio-Jurado, Benjamín; Balderas-Peña, Luz-Ma-Adriana; García-Luna, Eduardo E.; Zavala-Cerna, María G.; Riebeling-Navarro, Carlos; Reyes, Pedro A.; Nava-Zavala, Arnulfo H.

Advances in Clinical Chemistry. ed. / Gregory S. Makowski. Vol. 85 2018. p. 71-89 (Advances in Clinical Chemistry; Vol. 85).

Research output: Chapter in Book/Report/Conference proceedingChapter

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AU - Balderas-Peña, Luz-Ma-Adriana

AU - García-Luna, Eduardo E.

AU - Zavala-Cerna, María G.

AU - Riebeling-Navarro, Carlos

AU - Reyes, Pedro A.

AU - Nava-Zavala, Arnulfo H.

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N2 - Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~ 20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia. Cancer-associated hypercoagulable and thrombotic states are influenced by abnormalities in the vascular wall and susceptibility to invasion, interference in blood flow and increase in circulating tissue factor and thrombin, activation of cell growth factors, the presence of a central catheter, chemotherapies, neoplasm type, and surgery. In cancer, thromboembolic complications are the second most frequent cause of death with pulmonary thromboembolism in ~ 50% of cases postmortem. Thrombosis worsens prognosis as demonstrated with a survival rate as low as 12% per year vs 36% in nonthrombic patients. Deep vein thrombosis is the most frequent thromboembolic complication in cancer. It is usually detected at diagnosis and within the first 3 months of chemotherapy. The underlining mechanisms of this association should be further studied to identify patients at higher risk and develop adequate prevention, diagnostic, and treatment measures. The D-dimer test can be successfully used to assess the fibrinolytic phase of coagulation and as such is routinely used in suspected cases of deep vein thrombosis and pulmonary thromboembolism. In addition, significant advances have been made in understanding the composition and functional capabilities of the gut microbiota in the inflammatory process, obesity, and its roles in cancer; however, the intricate balance that exists within the microbiota may not only affect the host directly, it can also disrupt the entire microbial community. Conclusions: Cancer is a prothrombotic and inflammatory state in which the activation of coagulation is related to tumor growth, angiogenesis, and metastasis. It is important to identify the relationship between body mass index with these processes and clarify their importance in cancer prognosis. Future research should answer the question if manipulation of resident microbial communities could potentially improve prognosis and treatment outcome.

AB - Neoplasms exhibits a high incidence and mortality rates due to their complex and commonly overlapping clinical, biochemical, and morphologic profiles influenced by acquired or inherited molecular abnormalities, cell of origin, and level of differentiation. Obesity appears related to ~ 20% of cancers including endometrial, esophageal, colorectal, postmenopausal breast, prostate, and renal. Several factors other than obesity, i.e., insulin, insulin-like growth factor, sexual hormones, and adipokines may play a potential role in neoplasia. Cancer-associated hypercoagulable and thrombotic states are influenced by abnormalities in the vascular wall and susceptibility to invasion, interference in blood flow and increase in circulating tissue factor and thrombin, activation of cell growth factors, the presence of a central catheter, chemotherapies, neoplasm type, and surgery. In cancer, thromboembolic complications are the second most frequent cause of death with pulmonary thromboembolism in ~ 50% of cases postmortem. Thrombosis worsens prognosis as demonstrated with a survival rate as low as 12% per year vs 36% in nonthrombic patients. Deep vein thrombosis is the most frequent thromboembolic complication in cancer. It is usually detected at diagnosis and within the first 3 months of chemotherapy. The underlining mechanisms of this association should be further studied to identify patients at higher risk and develop adequate prevention, diagnostic, and treatment measures. The D-dimer test can be successfully used to assess the fibrinolytic phase of coagulation and as such is routinely used in suspected cases of deep vein thrombosis and pulmonary thromboembolism. In addition, significant advances have been made in understanding the composition and functional capabilities of the gut microbiota in the inflammatory process, obesity, and its roles in cancer; however, the intricate balance that exists within the microbiota may not only affect the host directly, it can also disrupt the entire microbial community. Conclusions: Cancer is a prothrombotic and inflammatory state in which the activation of coagulation is related to tumor growth, angiogenesis, and metastasis. It is important to identify the relationship between body mass index with these processes and clarify their importance in cancer prognosis. Future research should answer the question if manipulation of resident microbial communities could potentially improve prognosis and treatment outcome.

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Rubio-Jurado B, Balderas-Peña L-M-A, García-Luna EE, Zavala-Cerna MG, Riebeling-Navarro C, Reyes PA et al. Obesity, Thrombotic Risk, and Inflammation in Cancer. In Makowski GS, editor, Advances in Clinical Chemistry. Vol. 85. 2018. p. 71-89. (Advances in Clinical Chemistry). https://doi.org/10.1016/bs.acc.2018.02.006