TY - JOUR
T1 - Noise enhanced the electrical stimulation-contractile response coupling in isolated mouse heart
AU - Peña-Romo, Alberto
AU - Gámez-Méndez, Ana María
AU - Ríos, Amelia
AU - Escalante, Bruno A
AU - Rodríguez-González, Jesús
N1 - Funding Information:
This research was partially supported by Consejo Nacional de Ciencia y Tecnología (CONACYT, Mexico) under grant no. 105649 .
Publisher Copyright:
© 2016 Elsevier Ireland Ltd
PY - 2016/10/15
Y1 - 2016/10/15
N2 - BACKGROUND: Stochastic resonance is a phenomenon that allows a system to improve its capability to detect stimulus when a limited amount of noise is added to the stimuli. It has experimentally been shown that noise enhances the homeostatic function of the blood pressure regulatory system. This study aimed to investigate whether the noise can enhance the contractile response in the whole heart.METHODS: Experiments were conducted in isolated mouse hearts (0.040kg, n=8), a Langendorff heart preparation is used to obtain two variables of the contractile response contraction force and heart rate. The contractile response due to an electrical stimulation perturbed with Gaussian noise was recorded.RESULTS: The results show that the intensity of noise induced in the electrical stimuli has an effect on the electrical stimulation-contractile response coupling. With 10% noise induced, the bandwidth where the synchronization effect is presented was increased from (7-11Hz) to (6-12Hz), and the irregular dynamic threshold was changed to 13Hz.CONCLUSIONS: We find that the noise increases the synchronization bandwidth in the electrical stimulation-contractile response coupling. We have experimentally demonstrated the stochastic resonance in isolated mouse heart.
AB - BACKGROUND: Stochastic resonance is a phenomenon that allows a system to improve its capability to detect stimulus when a limited amount of noise is added to the stimuli. It has experimentally been shown that noise enhances the homeostatic function of the blood pressure regulatory system. This study aimed to investigate whether the noise can enhance the contractile response in the whole heart.METHODS: Experiments were conducted in isolated mouse hearts (0.040kg, n=8), a Langendorff heart preparation is used to obtain two variables of the contractile response contraction force and heart rate. The contractile response due to an electrical stimulation perturbed with Gaussian noise was recorded.RESULTS: The results show that the intensity of noise induced in the electrical stimuli has an effect on the electrical stimulation-contractile response coupling. With 10% noise induced, the bandwidth where the synchronization effect is presented was increased from (7-11Hz) to (6-12Hz), and the irregular dynamic threshold was changed to 13Hz.CONCLUSIONS: We find that the noise increases the synchronization bandwidth in the electrical stimulation-contractile response coupling. We have experimentally demonstrated the stochastic resonance in isolated mouse heart.
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U2 - 10.1016/j.ijcard.2016.06.130
DO - 10.1016/j.ijcard.2016.06.130
M3 - Article
C2 - 27400314
SN - 0167-5273
VL - 221
SP - 155
EP - 160
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -