New biomarkers in non-Hodgkin lymphoma and acute leukemias

Benjamín Rubio-Jurado, Lluvia Sugey Sosa-Quintero, Ivette Lenina Carrasco-Martinez, Armando Norato-Delgado, Eduardo Garcia-Luna, Sandra Guzmán-Silahua, Carlos Riebeling-Navarro, Arnulfo Hernan Nava-Zavala

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Biomarkers play a critical role in the medical care of patients with cancer, including in early detection of the disease, diagnostic accuracy, risk stratification, treatment, and follow-up. Biomarkers in hematological malignancies can support the redefinition of the diagnosis and adjustments in the treatment plan. Biomarkers can be classified into 4 categories: (1) protein antigens, (2) cytogenetic abnormalities, (3) genetic polymorphisms, and (4) gene expression. Efforts in genomics, proteomics, and metabolomics to observe new biomarkers that contribute to the development of clinical medicine with greater precision in the strategies that improve prevention, diagnosis, and treatment of patients with malignant hematological disease. New biomarkers should accomplish several issues such as the biological plausibility, methodology used, analytical validation, intellectual property registry, and legal framework of application. This knowledge should be transferred to health professionals who can carry out the process of its implementation in clinical practice.

Original languageEnglish
Title of host publicationAdvances in Clinical Chemistry
EditorsGregory S. Makowski
PublisherAcademic Press Inc.
Pages19-53
Number of pages35
ISBN (Print)9780128211663
DOIs
Publication statusPublished - 2020

Publication series

NameAdvances in Clinical Chemistry
Volume96
ISSN (Print)0065-2423
ISSN (Electronic)2162-9471

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Clinical Biochemistry

Cite this

Rubio-Jurado, B., Sosa-Quintero, L. S., Carrasco-Martinez, I. L., Norato-Delgado, A., Garcia-Luna, E., Guzmán-Silahua, S., Riebeling-Navarro, C., & Nava-Zavala, A. H. (2020). New biomarkers in non-Hodgkin lymphoma and acute leukemias. In G. S. Makowski (Ed.), Advances in Clinical Chemistry (pp. 19-53). (Advances in Clinical Chemistry; Vol. 96). Academic Press Inc.. https://doi.org/10.1016/bs.acc.2019.11.002