Nerve growth factor increases sodium current in pancreatic β cells

T. Rosenbaum, R. Vidaltamayo, D. Sánchez-Herrera, M. Hiriart

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Nerve growth factor (NGF) induces neurite-like process outgrowth in cultured adult pancreatic β cells. DbcAMP partially mimics this effect on cell morphology, and both compounds act synergistically to promote neurite-like process outgrowth. To determine if NGF- and dbcAMP-induced differentiation was accompanied by changes in β cell electrical activity, we studied the macroscopic Na current of adult rat β cells identified with the reverse hemolytic plaque assay and cultured for one week with these factors. After 5-7 days, β cells cultured in the presence of 2.5S NGF exhibited a 48% increase on the macroscopic Na current, which was due to an increase on Na current density. We did not observe changes on voltage dependence of current activation, nor on steady-state inactivation. Although dbcAMP also promotes changes on β cell morphology, it did not affect the Na current density.
Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalJournal of Membrane Biology
Publication statusPublished - 8 Oct 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Physiology
  • Cell Biology


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