Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.

M. Hiriart, R. Vidaltamayo, M. C. Sánchez-Soto

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.
Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalThe Israel Medical Association journal : IMAJ
Volume3
Issue number2
Publication statusPublished - 1 Feb 2001
Externally publishedYes

Bibliographical note

Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.'. Together they form a unique fingerprint.

Cite this