Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.
|Number of pages||3|
|Journal||The Israel Medical Association journal : IMAJ|
|Publication status||Published - 1 Feb 2001|
All Science Journal Classification (ASJC) codes
Hiriart, M., Vidaltamayo, R., & Sánchez-Soto, M. C. (2001). Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion. The Israel Medical Association journal : IMAJ, 114-116.