Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.

M. Hiriart, R. Vidaltamayo, M. C. Sánchez-Soto

Research output: Contribution to journalLiterature review

10 Citations (Scopus)

Abstract

Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.
Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalThe Israel Medical Association journal : IMAJ
Publication statusPublished - 1 Feb 2001
Externally publishedYes

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Nerve Growth Factors
Insulin-Secreting Cells
Nerve Growth Factor
Islets of Langerhans
Fibroblasts
Insulin
Cell Physiological Phenomena
Neurites
Diabetes Mellitus
Glucose
Cell Plasticity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.",
abstract = "Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.",
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journal = "Israel Medical Association Journal",
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Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion. / Hiriart, M.; Vidaltamayo, R.; Sánchez-Soto, M. C.

In: The Israel Medical Association journal : IMAJ, 01.02.2001, p. 114-116.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.

AU - Hiriart, M.

AU - Vidaltamayo, R.

AU - Sánchez-Soto, M. C.

PY - 2001/2/1

Y1 - 2001/2/1

N2 - Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.

AB - Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.

M3 - Literature review

SP - 114

EP - 116

JO - Israel Medical Association Journal

JF - Israel Medical Association Journal

SN - 1565-1088

ER -