Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.

M. Hiriart, R. Vidaltamayo, M. C. Sánchez-Soto

Research output: Contribution to journalLiterature reviewpeer-review

10 Citations (Scopus)

Abstract

Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.
Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalThe Israel Medical Association journal : IMAJ
Publication statusPublished - 1 Feb 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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