Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.

M. Hiriart; R. Vidaltamayo; M. C. Sánchez-Soto

Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.

M. Hiriart, R. Vidaltamayo, M. C. Sánchez-Soto

Research output: Contribution to journal › Review article › peer-review

Abstract

Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.

Original language	English
Pages (from-to)	114-116
Number of pages	3
Journal	The Israel Medical Association journal : IMAJ
Volume	3
Issue number	2
Publication status	Published - 1 Feb 2001
Externally published	Yes

Bibliographical note

Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

All Science Journal Classification (ASJC) codes

General Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.",

abstract = "Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.",

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AU - Hiriart, M.

AU - Vidaltamayo, R.

AU - Sánchez-Soto, M. C.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2001/2/1

Y1 - 2001/2/1

N2 - Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.

AB - Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.

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M3 - Review article

SN - 1565-1088

VL - 3

SP - 114

EP - 116

JO - The Israel Medical Association journal : IMAJ

JF - The Israel Medical Association journal : IMAJ

IS - 2

ER -

Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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