Nephroprotective effect of Sonchus oleraceus extract against kidney injury induced by ischemia-reperfusion in Wistar rats

Liliana Torres-González, Eduardo Cienfuegos-Pecina, Marlene M. Perales-Quintana, Gabriela Alarcon-Galvan, Linda E. Muñoz-Espinosa, Edelmiro Pérez-Rodríguez, Paula Cordero-Pérez

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Copyright © 2018 Liliana Torres-González et al. Introduction. Kidney ischemia-reperfusion (I/R) injury is the main cause of delayed graft function in solid organ transplantation. Sonchus oleraceus is a plant with well-known antioxidant and anti-inflammatory activities; however, its effects on renal I/R are unknown. Objective. To evaluate whether S. oleraceus extract (S.O.e.) has nephroprotective activity in an I/R model in Wistar rats. Materials and Methods. Animal groups (n = 6): sham, I/R (45 min/15 h), S.O.e (300 mg/kg p.o.), and S.O.e + I/R (300 mg/kg, p.o.; 45 min/15 h). Renal function, proinflammatory cytokines, alanine aminotransferase, markers of oxidative stress, and histology were evaluated. Results. None of the mediators evaluated differed significantly between the S.O.e and sham groups. Levels of blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), and proinflammatory cytokines were higher, and superoxide dismutase (SOD) was lower in the I/R group than in the sham group. Histology showed tubular epithelial necrosis in the medulla and cortex in the I/R group. In the S.O.e + I/R group, S.O.e pretreatment attenuated the I/R-induced increases in BUN, creatinine, MDA, and proinflammatory cytokines induced, SOD was maintained, and histology showed discontinuous necrosis in the medulla but no necrosis in the cortex. Conclusions. S.O.e was neither hepatotoxic nor nephrotoxic. S.O.e. pretreatment showed a nephroprotective effect against I/R.
Original languageEnglish
JournalOxidative Medicine and Cellular Longevity
DOIs
Publication statusPublished - 1 Jan 2018

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Sonchus
Histology
Reperfusion Injury
Reperfusion
Wistar Rats
Rats
Ischemia
Cytokines
Malondialdehyde
Kidney
Superoxide Dismutase
Urea
Creatinine
Blood
Nitrogen
Transplantation (surgical)
Oxidative stress
Alanine Transaminase
Grafts
Necrosis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Cell Biology

Cite this

Torres-González, L., Cienfuegos-Pecina, E., Perales-Quintana, M. M., Alarcon-Galvan, G., Muñoz-Espinosa, L. E., Pérez-Rodríguez, E., & Cordero-Pérez, P. (2018). Nephroprotective effect of Sonchus oleraceus extract against kidney injury induced by ischemia-reperfusion in Wistar rats. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2018/9572803
Torres-González, Liliana ; Cienfuegos-Pecina, Eduardo ; Perales-Quintana, Marlene M. ; Alarcon-Galvan, Gabriela ; Muñoz-Espinosa, Linda E. ; Pérez-Rodríguez, Edelmiro ; Cordero-Pérez, Paula. / Nephroprotective effect of Sonchus oleraceus extract against kidney injury induced by ischemia-reperfusion in Wistar rats. In: Oxidative Medicine and Cellular Longevity. 2018.
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abstract = "Copyright {\circledC} 2018 Liliana Torres-Gonz{\'a}lez et al. Introduction. Kidney ischemia-reperfusion (I/R) injury is the main cause of delayed graft function in solid organ transplantation. Sonchus oleraceus is a plant with well-known antioxidant and anti-inflammatory activities; however, its effects on renal I/R are unknown. Objective. To evaluate whether S. oleraceus extract (S.O.e.) has nephroprotective activity in an I/R model in Wistar rats. Materials and Methods. Animal groups (n = 6): sham, I/R (45 min/15 h), S.O.e (300 mg/kg p.o.), and S.O.e + I/R (300 mg/kg, p.o.; 45 min/15 h). Renal function, proinflammatory cytokines, alanine aminotransferase, markers of oxidative stress, and histology were evaluated. Results. None of the mediators evaluated differed significantly between the S.O.e and sham groups. Levels of blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), and proinflammatory cytokines were higher, and superoxide dismutase (SOD) was lower in the I/R group than in the sham group. Histology showed tubular epithelial necrosis in the medulla and cortex in the I/R group. In the S.O.e + I/R group, S.O.e pretreatment attenuated the I/R-induced increases in BUN, creatinine, MDA, and proinflammatory cytokines induced, SOD was maintained, and histology showed discontinuous necrosis in the medulla but no necrosis in the cortex. Conclusions. S.O.e was neither hepatotoxic nor nephrotoxic. S.O.e. pretreatment showed a nephroprotective effect against I/R.",
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Nephroprotective effect of Sonchus oleraceus extract against kidney injury induced by ischemia-reperfusion in Wistar rats. / Torres-González, Liliana; Cienfuegos-Pecina, Eduardo; Perales-Quintana, Marlene M.; Alarcon-Galvan, Gabriela; Muñoz-Espinosa, Linda E.; Pérez-Rodríguez, Edelmiro; Cordero-Pérez, Paula.

In: Oxidative Medicine and Cellular Longevity, 01.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nephroprotective effect of Sonchus oleraceus extract against kidney injury induced by ischemia-reperfusion in Wistar rats

AU - Torres-González, Liliana

AU - Cienfuegos-Pecina, Eduardo

AU - Perales-Quintana, Marlene M.

AU - Alarcon-Galvan, Gabriela

AU - Muñoz-Espinosa, Linda E.

AU - Pérez-Rodríguez, Edelmiro

AU - Cordero-Pérez, Paula

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Copyright © 2018 Liliana Torres-González et al. Introduction. Kidney ischemia-reperfusion (I/R) injury is the main cause of delayed graft function in solid organ transplantation. Sonchus oleraceus is a plant with well-known antioxidant and anti-inflammatory activities; however, its effects on renal I/R are unknown. Objective. To evaluate whether S. oleraceus extract (S.O.e.) has nephroprotective activity in an I/R model in Wistar rats. Materials and Methods. Animal groups (n = 6): sham, I/R (45 min/15 h), S.O.e (300 mg/kg p.o.), and S.O.e + I/R (300 mg/kg, p.o.; 45 min/15 h). Renal function, proinflammatory cytokines, alanine aminotransferase, markers of oxidative stress, and histology were evaluated. Results. None of the mediators evaluated differed significantly between the S.O.e and sham groups. Levels of blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), and proinflammatory cytokines were higher, and superoxide dismutase (SOD) was lower in the I/R group than in the sham group. Histology showed tubular epithelial necrosis in the medulla and cortex in the I/R group. In the S.O.e + I/R group, S.O.e pretreatment attenuated the I/R-induced increases in BUN, creatinine, MDA, and proinflammatory cytokines induced, SOD was maintained, and histology showed discontinuous necrosis in the medulla but no necrosis in the cortex. Conclusions. S.O.e was neither hepatotoxic nor nephrotoxic. S.O.e. pretreatment showed a nephroprotective effect against I/R.

AB - Copyright © 2018 Liliana Torres-González et al. Introduction. Kidney ischemia-reperfusion (I/R) injury is the main cause of delayed graft function in solid organ transplantation. Sonchus oleraceus is a plant with well-known antioxidant and anti-inflammatory activities; however, its effects on renal I/R are unknown. Objective. To evaluate whether S. oleraceus extract (S.O.e.) has nephroprotective activity in an I/R model in Wistar rats. Materials and Methods. Animal groups (n = 6): sham, I/R (45 min/15 h), S.O.e (300 mg/kg p.o.), and S.O.e + I/R (300 mg/kg, p.o.; 45 min/15 h). Renal function, proinflammatory cytokines, alanine aminotransferase, markers of oxidative stress, and histology were evaluated. Results. None of the mediators evaluated differed significantly between the S.O.e and sham groups. Levels of blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), and proinflammatory cytokines were higher, and superoxide dismutase (SOD) was lower in the I/R group than in the sham group. Histology showed tubular epithelial necrosis in the medulla and cortex in the I/R group. In the S.O.e + I/R group, S.O.e pretreatment attenuated the I/R-induced increases in BUN, creatinine, MDA, and proinflammatory cytokines induced, SOD was maintained, and histology showed discontinuous necrosis in the medulla but no necrosis in the cortex. Conclusions. S.O.e was neither hepatotoxic nor nephrotoxic. S.O.e. pretreatment showed a nephroprotective effect against I/R.

U2 - 10.1155/2018/9572803

DO - 10.1155/2018/9572803

M3 - Article

JO - Oxidative Medicine and Cellular Longevity

JF - Oxidative Medicine and Cellular Longevity

SN - 1942-0900

ER -