In this work, flower-like molybdenum disulfide (MoS 2 ) microspheres were produced with polyethylene glycol (PEG) to form MoS 2-PEG. Likewise, gold nanoparticles (AuNPs) were added to form MoS 2-PEG/Au to investigate its potential application as a theranostic nanomaterial. These nanomaterials were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), photoelectron X-ray spectroscopy (XPS), Fourier-transformed infrared spectroscopy (FTIR), cyclic voltammetry and impedance spectroscopy. The produced hierarchical MoS 2-PEG/Au microstructures showed an average diameter of 400 nm containing distributed gold nanoparticles, with great cellular viability on tumoral and non-tumoral cells. This aspect makes them with multifunctional characteristics with potential application for cancer diagnosis and therapy. Through the complete morphological and physicochemical characterization, it was possible to observe that both MoS 2-PEG and MoS 2-PEG/Au showed good chemical stability and demonstrated noninterference in the pattern of the cell nucleus, as well. Thus, our results suggest the possible application of these hybrid nanomaterials can be immensely explored for theranostic proposals in biomedicine.
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Acknowledgments: The authors would like to thank Universidad de Monterrey, Mexico, and Professor Flávio Guimarães da Fonseca from Laboratório de Virologia Básica e Aplicada da Universidade Federal de Minas Gerais, for the use of his facilities, Brazil National Council for Scientific and Technological Development (CNPq), and Coordination for the Improvement of Higher Education Personnel-Brazil (CAPES) and MackPesquisa.
Funding: This research was sponsored by Mackenzie Research Fund (MackPesquisa, Project No. 181009), National Council for Scientific and Technological Development (CNPq), Coordination for the Improvement of Higher Education Personnel-Brazil (CAPES), and the Universidad de Monterrey.
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