Multifunctional Hybrid MoS2-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine

Thiago  Malagrino; Anna Godoy; Juliano Barbosa; Abner Lima; Nei Souza; Jairo Pedrotti; Pamela Garcia; Roberto Paniago; Lidia Andrade; Sergio Domingues; Wellington Silva; Helio Ribeiro; Jaime Taha-Tijerina

doi:https://doi.org/10.3390/nano12122053

Multifunctional Hybrid MoS2-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine

Thiago Malagrino , Anna Godoy, Juliano Barbosa, Abner Lima, Nei Souza, Jairo Pedrotti, Pamela Garcia, Roberto Paniago, Lidia Andrade, Sergio Domingues, Wellington Silva, Helio Ribeiro, Jaime Taha-Tijerina

Departamento de Ingeniería Mecánica y Eléctrica

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In this work, flower-like molybdenum disulfide (MoS ₂ ) microspheres were produced with polyethylene glycol (PEG) to form MoS ₂-PEG. Likewise, gold nanoparticles (AuNPs) were added to form MoS ₂-PEG/Au to investigate its potential application as a theranostic nanomaterial. These nanomaterials were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), photoelectron X-ray spectroscopy (XPS), Fourier-transformed infrared spectroscopy (FTIR), cyclic voltammetry and impedance spectroscopy. The produced hierarchical MoS ₂-PEG/Au microstructures showed an average diameter of 400 nm containing distributed gold nanoparticles, with great cellular viability on tumoral and non-tumoral cells. This aspect makes them with multifunctional characteristics with potential application for cancer diagnosis and therapy. Through the complete morphological and physicochemical characterization, it was possible to observe that both MoS ₂-PEG and MoS ₂-PEG/Au showed good chemical stability and demonstrated noninterference in the pattern of the cell nucleus, as well. Thus, our results suggest the possible application of these hybrid nanomaterials can be immensely explored for theranostic proposals in biomedicine.

Original language	English
Article number	2053
Pages (from-to)	2053
Number of pages	18
Journal	Nanomaterials
Volume	12
Issue number	12
DOIs	https://doi.org/10.3390/nano12122053
Publication status	Published - 1 Jun 2022

Bibliographical note

Funding Information:
Acknowledgments: The authors would like to thank Universidad de Monterrey, Mexico, and Professor Flávio Guimarães da Fonseca from Laboratório de Virologia Básica e Aplicada da Universidade Federal de Minas Gerais, for the use of his facilities, Brazil National Council for Scientific and Technological Development (CNPq), and Coordination for the Improvement of Higher Education Personnel-Brazil (CAPES) and MackPesquisa.

Funding Information:
Funding: This research was sponsored by Mackenzie Research Fund (MackPesquisa, Project No. 181009), National Council for Scientific and Technological Development (CNPq), Coordination for the Improvement of Higher Education Personnel-Brazil (CAPES), and the Universidad de Monterrey.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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Malagrino , T., Godoy, A., Barbosa, J., Lima, A., Souza, N., Pedrotti, J., Garcia, P., Paniago, R., Andrade, L., Domingues, S., Silva, W., Ribeiro, H., & Taha-Tijerina, J. (2022). Multifunctional Hybrid MoS2-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine. Nanomaterials, 12(12), 2053. Article 2053. https://doi.org/10.3390/nano12122053

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abstract = "In this work, flower-like molybdenum disulfide (MoS 2 ) microspheres were produced with polyethylene glycol (PEG) to form MoS 2-PEG. Likewise, gold nanoparticles (AuNPs) were added to form MoS 2-PEG/Au to investigate its potential application as a theranostic nanomaterial. These nanomaterials were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), photoelectron X-ray spectroscopy (XPS), Fourier-transformed infrared spectroscopy (FTIR), cyclic voltammetry and impedance spectroscopy. The produced hierarchical MoS 2-PEG/Au microstructures showed an average diameter of 400 nm containing distributed gold nanoparticles, with great cellular viability on tumoral and non-tumoral cells. This aspect makes them with multifunctional characteristics with potential application for cancer diagnosis and therapy. Through the complete morphological and physicochemical characterization, it was possible to observe that both MoS 2-PEG and MoS 2-PEG/Au showed good chemical stability and demonstrated noninterference in the pattern of the cell nucleus, as well. Thus, our results suggest the possible application of these hybrid nanomaterials can be immensely explored for theranostic proposals in biomedicine.",

author = "Thiago Malagrino and Anna Godoy and Juliano Barbosa and Abner Lima and Nei Souza and Jairo Pedrotti and Pamela Garcia and Roberto Paniago and Lidia Andrade and Sergio Domingues and Wellington Silva and Helio Ribeiro and Jaime Taha-Tijerina",

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AU - Lima, Abner

AU - Souza, Nei

AU - Pedrotti, Jairo

AU - Garcia, Pamela

AU - Paniago, Roberto

AU - Andrade, Lidia

AU - Domingues, Sergio

AU - Silva, Wellington

AU - Ribeiro, Helio

AU - Taha-Tijerina, Jaime

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Multifunctional Hybrid MoS2-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine

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