TY - JOUR
T1 - Molecular concentration of deoxyHb in human prefrontal cortex predicts the emergence and suppression of consciousness
AU - Leon-Dominguez, Umberto
AU - Izzetoglu, Meltem
AU - Leon-Carrion, Jose
AU - Solís-Marcos, Ignacio
AU - Garcia-Torrado, Francisco Jose
AU - Forastero-Rodríguez, Ana
AU - Mellado-Miras, Patricia
AU - Villegas-Duque, Diego
AU - Lopez-Romero, Juan Luis
AU - Onaral, Banu
AU - Izzetoglu, Kurtulus
N1 - Funding Information:
Funding for this study was provided by a grant from the Wallace H. Coulter Foundation (internal grant numbers: 270195 and 282805).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/1/15
Y1 - 2014/1/15
N2 - This is the first study to use fNIRS to explore anaesthetic depth and awakening during surgery with general anaesthesia. A 16 channel continuous wave (CW) functional near-infrared system (fNIRS) was used to monitor PFC activity. These outcomes were compared to BIS measures. The results indicate that deoxyHb concentration in the PFC varies during the suppression and emergence of consciousness. During suppression, deoxyHb levels increase, signalling the deactivation of the PFC, while during emergence, deoxyHb concentration drops, initiating PFC activation and the recovery of consciousness. Furthermore, BIS and deoxyHb concentrations in the PFC display a high negative correlation throughout the different anaesthetic phases. These findings suggest that deoxyHb could be a reliable marker for monitoring anaesthetic depth, and that the PFC intervenes in the suppression and emergence of consciousness.
AB - This is the first study to use fNIRS to explore anaesthetic depth and awakening during surgery with general anaesthesia. A 16 channel continuous wave (CW) functional near-infrared system (fNIRS) was used to monitor PFC activity. These outcomes were compared to BIS measures. The results indicate that deoxyHb concentration in the PFC varies during the suppression and emergence of consciousness. During suppression, deoxyHb levels increase, signalling the deactivation of the PFC, while during emergence, deoxyHb concentration drops, initiating PFC activation and the recovery of consciousness. Furthermore, BIS and deoxyHb concentrations in the PFC display a high negative correlation throughout the different anaesthetic phases. These findings suggest that deoxyHb could be a reliable marker for monitoring anaesthetic depth, and that the PFC intervenes in the suppression and emergence of consciousness.
UR - http://www.scopus.com/inward/record.url?scp=84889639046&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84889639046&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/9098a0ae-3a92-3529-bd49-41e880f26e94/
U2 - 10.1016/j.neuroimage.2013.07.023
DO - 10.1016/j.neuroimage.2013.07.023
M3 - Article
SN - 1053-8119
VL - 85
SP - 616
EP - 625
JO - NeuroImage
JF - NeuroImage
ER -