Molecular concentration of deoxyHb in human prefrontal cortex predicts the emergence and suppression of consciousness

Umberto Leon-Dominguez, Meltem Izzetoglu, Jose Leon-Carrion, Ignacio Solís-Marcos, Francisco Jose Garcia-Torrado, Ana Forastero-Rodríguez, Patricia Mellado-Miras, Diego Villegas-Duque, Juan Luis Lopez-Romero, Banu Onaral, Kurtulus Izzetoglu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This is the first study to use fNIRS to explore anaesthetic depth and awakening during surgery with general anaesthesia. A 16 channel continuous wave (CW) functional near-infrared system (fNIRS) was used to monitor PFC activity. These outcomes were compared to BIS measures. The results indicate that deoxyHb concentration in the PFC varies during the suppression and emergence of consciousness. During suppression, deoxyHb levels increase, signalling the deactivation of the PFC, while during emergence, deoxyHb concentration drops, initiating PFC activation and the recovery of consciousness. Furthermore, BIS and deoxyHb concentrations in the PFC display a high negative correlation throughout the different anaesthetic phases. These findings suggest that deoxyHb could be a reliable marker for monitoring anaesthetic depth, and that the PFC intervenes in the suppression and emergence of consciousness. © 2013 Elsevier Inc.
Original languageEnglish
Pages (from-to)616-625
Number of pages10
JournalNeuroImage
DOIs
Publication statusPublished - 15 Jan 2014
Externally publishedYes

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Prefrontal Cortex
Consciousness
Anesthetics
General Anesthesia

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Leon-Dominguez, U., Izzetoglu, M., Leon-Carrion, J., Solís-Marcos, I., Garcia-Torrado, F. J., Forastero-Rodríguez, A., ... Izzetoglu, K. (2014). Molecular concentration of deoxyHb in human prefrontal cortex predicts the emergence and suppression of consciousness. NeuroImage, 616-625. https://doi.org/10.1016/j.neuroimage.2013.07.023
Leon-Dominguez, Umberto ; Izzetoglu, Meltem ; Leon-Carrion, Jose ; Solís-Marcos, Ignacio ; Garcia-Torrado, Francisco Jose ; Forastero-Rodríguez, Ana ; Mellado-Miras, Patricia ; Villegas-Duque, Diego ; Lopez-Romero, Juan Luis ; Onaral, Banu ; Izzetoglu, Kurtulus. / Molecular concentration of deoxyHb in human prefrontal cortex predicts the emergence and suppression of consciousness. In: NeuroImage. 2014 ; pp. 616-625.
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abstract = "This is the first study to use fNIRS to explore anaesthetic depth and awakening during surgery with general anaesthesia. A 16 channel continuous wave (CW) functional near-infrared system (fNIRS) was used to monitor PFC activity. These outcomes were compared to BIS measures. The results indicate that deoxyHb concentration in the PFC varies during the suppression and emergence of consciousness. During suppression, deoxyHb levels increase, signalling the deactivation of the PFC, while during emergence, deoxyHb concentration drops, initiating PFC activation and the recovery of consciousness. Furthermore, BIS and deoxyHb concentrations in the PFC display a high negative correlation throughout the different anaesthetic phases. These findings suggest that deoxyHb could be a reliable marker for monitoring anaesthetic depth, and that the PFC intervenes in the suppression and emergence of consciousness. {\circledC} 2013 Elsevier Inc.",
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Leon-Dominguez, U, Izzetoglu, M, Leon-Carrion, J, Solís-Marcos, I, Garcia-Torrado, FJ, Forastero-Rodríguez, A, Mellado-Miras, P, Villegas-Duque, D, Lopez-Romero, JL, Onaral, B & Izzetoglu, K 2014, 'Molecular concentration of deoxyHb in human prefrontal cortex predicts the emergence and suppression of consciousness', NeuroImage, pp. 616-625. https://doi.org/10.1016/j.neuroimage.2013.07.023

Molecular concentration of deoxyHb in human prefrontal cortex predicts the emergence and suppression of consciousness. / Leon-Dominguez, Umberto; Izzetoglu, Meltem; Leon-Carrion, Jose; Solís-Marcos, Ignacio; Garcia-Torrado, Francisco Jose; Forastero-Rodríguez, Ana; Mellado-Miras, Patricia; Villegas-Duque, Diego; Lopez-Romero, Juan Luis; Onaral, Banu; Izzetoglu, Kurtulus.

In: NeuroImage, 15.01.2014, p. 616-625.

Research output: Contribution to journalArticle

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AU - Garcia-Torrado, Francisco Jose

AU - Forastero-Rodríguez, Ana

AU - Mellado-Miras, Patricia

AU - Villegas-Duque, Diego

AU - Lopez-Romero, Juan Luis

AU - Onaral, Banu

AU - Izzetoglu, Kurtulus

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