Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización

Jorge Bátiz-Armenta, Andrea Ferranti Ramos, Gerardo Francisco Javier Rivera Silva, Guillermo H. Martínez-Delgado, Francisco De la Garza Alvarez, Héctor R. Martínez-Menchaca

Research output: Contribution to journalArticle

Abstract

Introduction: Matrix metalloproteinases are essential for structural maintenance of extracellular matrix enzymes, as well as degradation in situations where tissue repair process is warranted. Objective: To review the most current aspects of matrix metalloproteinases and their role in the healing process. Research Methodology: A review of about 95 papers was conducted during the period from July 18, 2015 to September 20, 2016; PubMed, Scopus, Scielo and Science Direct were used. Results: There are six subfamilies of metalloproteinases: collagenases, stromalysins, elastases, gelatinases, matrilysins and metalloproteinases associated with the plasma membrane. Vascular endothelial cells secrete them where there is epithelial damage and a healing process is required. Conclusions: Metalloproteinases are zinc dependent endopeptidases that are essential for the maintenance and degradation of the extracellular matrix. When the adjustment mechanism fails and matrix metalloproteinases are overexpressed, poor healing processes occur, causing problems such as liver chronic wounds, keloids or hypertrophic scars, pterygium, pulmonary and liver fibrosis, among other clinical conditions. (English) [ABSTRACT FROM AUTHOR]
Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalRevista Médicas UIS
Volume30
Issue number3
DOIs
Publication statusPublished - 20 Dec 2017

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Metalloproteases
Matrix Metalloproteinases
Extracellular Matrix
Maintenance
Matrix Metalloproteinase 7
Hypertrophic Cicatrix
Pterygium
Keloid
Gelatinases
Endopeptidases
Pulmonary Fibrosis
Pancreatic Elastase
Collagenases
PubMed
Liver Cirrhosis
Zinc
Research Design
Endothelial Cells
Cell Membrane
Liver

Cite this

Bátiz-Armenta, J., Ferranti Ramos, A., Rivera Silva, G. F. J., Martínez-Delgado, G. H., De la Garza Alvarez, F., & Martínez-Menchaca, H. R. (2017). Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización. Revista Médicas UIS, 30(3), 55-62. https://doi.org/10.18273/revmed.v30n2-2017006
Bátiz-Armenta, Jorge ; Ferranti Ramos, Andrea ; Rivera Silva, Gerardo Francisco Javier ; Martínez-Delgado, Guillermo H. ; De la Garza Alvarez, Francisco ; Martínez-Menchaca, Héctor R. / Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización. In: Revista Médicas UIS. 2017 ; Vol. 30, No. 3. pp. 55-62.
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Bátiz-Armenta, J, Ferranti Ramos, A, Rivera Silva, GFJ, Martínez-Delgado, GH, De la Garza Alvarez, F & Martínez-Menchaca, HR 2017, 'Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización', Revista Médicas UIS, vol. 30, no. 3, pp. 55-62. https://doi.org/10.18273/revmed.v30n2-2017006

Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización. / Bátiz-Armenta, Jorge; Ferranti Ramos, Andrea; Rivera Silva, Gerardo Francisco Javier; Martínez-Delgado, Guillermo H.; De la Garza Alvarez, Francisco; Martínez-Menchaca, Héctor R.

In: Revista Médicas UIS, Vol. 30, No. 3, 20.12.2017, p. 55-62.

Research output: Contribution to journalArticle

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T1 - Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización

AU - Bátiz-Armenta, Jorge

AU - Ferranti Ramos, Andrea

AU - Rivera Silva, Gerardo Francisco Javier

AU - Martínez-Delgado, Guillermo H.

AU - De la Garza Alvarez, Francisco

AU - Martínez-Menchaca, Héctor R.

PY - 2017/12/20

Y1 - 2017/12/20

N2 - Introduction: Matrix metalloproteinases are essential for structural maintenance of extracellular matrix enzymes, as well as degradation in situations where tissue repair process is warranted. Objective: To review the most current aspects of matrix metalloproteinases and their role in the healing process. Research Methodology: A review of about 95 papers was conducted during the period from July 18, 2015 to September 20, 2016; PubMed, Scopus, Scielo and Science Direct were used. Results: There are six subfamilies of metalloproteinases: collagenases, stromalysins, elastases, gelatinases, matrilysins and metalloproteinases associated with the plasma membrane. Vascular endothelial cells secrete them where there is epithelial damage and a healing process is required. Conclusions: Metalloproteinases are zinc dependent endopeptidases that are essential for the maintenance and degradation of the extracellular matrix. When the adjustment mechanism fails and matrix metalloproteinases are overexpressed, poor healing processes occur, causing problems such as liver chronic wounds, keloids or hypertrophic scars, pterygium, pulmonary and liver fibrosis, among other clinical conditions. (English) [ABSTRACT FROM AUTHOR]

AB - Introduction: Matrix metalloproteinases are essential for structural maintenance of extracellular matrix enzymes, as well as degradation in situations where tissue repair process is warranted. Objective: To review the most current aspects of matrix metalloproteinases and their role in the healing process. Research Methodology: A review of about 95 papers was conducted during the period from July 18, 2015 to September 20, 2016; PubMed, Scopus, Scielo and Science Direct were used. Results: There are six subfamilies of metalloproteinases: collagenases, stromalysins, elastases, gelatinases, matrilysins and metalloproteinases associated with the plasma membrane. Vascular endothelial cells secrete them where there is epithelial damage and a healing process is required. Conclusions: Metalloproteinases are zinc dependent endopeptidases that are essential for the maintenance and degradation of the extracellular matrix. When the adjustment mechanism fails and matrix metalloproteinases are overexpressed, poor healing processes occur, causing problems such as liver chronic wounds, keloids or hypertrophic scars, pterygium, pulmonary and liver fibrosis, among other clinical conditions. (English) [ABSTRACT FROM AUTHOR]

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JO - Revista Médicas UIS

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SN - 0121-0319

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Bátiz-Armenta J, Ferranti Ramos A, Rivera Silva GFJ, Martínez-Delgado GH, De la Garza Alvarez F, Martínez-Menchaca HR. Metaloproteinasas de la matriz extracelular y su participación en el proceso de cicatrización. Revista Médicas UIS. 2017 Dec 20;30(3):55-62. https://doi.org/10.18273/revmed.v30n2-2017006