Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease

Antonio Martinez-Torteya; Monica Rivera-Davila; José M. Celaya-Padilla; José G. Tamez-Peña; Félix E. Rodríguez-Cantú

doi:10.1117/12.2514771

Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease

Antonio Martinez-Torteya, Monica Rivera-Davila, José M. Celaya-Padilla, José G. Tamez-Peña, Félix E. Rodríguez-Cantú

Departamento de Ingeniería

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Alzheimer's disease (AD) is the most common form of dementia, and an accurate diagnosis confers many clinical research and patient care benefits. The current research-setting criteria needs to consider at least one supportive biomarker before diagnosing a subject with AD, and brain atrophy measured using structural magnetic resonance is one of them. Yet, brain atrophy is currently defined using only volumetric information which could obviate localized morphological variations. We measured hippocampal neuroanatomical asymmetry from MR images of 417 subjects as a surrogate measurement of brain atrophy, anticipating that it would have a better sensitivity than volumetric information regarding differences between healthy controls and subjects with AD. Asymmetry was defined in terms of the overlapping voxels between left and right hippocampi after a co-registration process. We found a significant difference (p-value = 0.007) in discrimination power between hippocampal volume and neuroanatomical asymmetry. This result suggests that neuroanatomical asymmetry should be further studied to determine whether it could replace the current brain atrophy biomarker.

Original language	English
Title of host publication	Medical Imaging 2019
Subtitle of host publication	Biomedical Applications in Molecular, Structural, and Functional Imaging
Editors	Barjor Gimi, Andrzej Krol
Publisher	SPIE
Volume	10953
Edition	2019
ISBN (Electronic)	978-151062553-2
DOIs	https://doi.org/10.1117/12.2514771
Publication status	Published - 15 Mar 2019

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10953
ISSN (Print)	1605-7422

Bibliographical note

Funding Information:
This work was partially supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT) and by Universidad de Monterrey through the Fondo de Fomentos a la Investigación Grant.

Publisher Copyright:
© 2019 SPIE.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging
Biomaterials

Access to Document

10.1117/12.2514771

Cite this

Martinez-Torteya, A., Rivera-Davila, M., Celaya-Padilla, J. M., Tamez-Peña, J. G., & Rodríguez-Cantú, F. E. (2019). Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. In B. Gimi, & A. Krol (Eds.), Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging (2019 ed., Vol. 10953). [109530U] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10953). SPIE. https://doi.org/10.1117/12.2514771

Martinez-Torteya, Antonio ; Rivera-Davila, Monica ; Celaya-Padilla, José M. et al. / Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging. editor / Barjor Gimi ; Andrzej Krol. Vol. 10953 2019. ed. SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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abstract = "Alzheimer's disease (AD) is the most common form of dementia, and an accurate diagnosis confers many clinical research and patient care benefits. The current research-setting criteria needs to consider at least one supportive biomarker before diagnosing a subject with AD, and brain atrophy measured using structural magnetic resonance is one of them. Yet, brain atrophy is currently defined using only volumetric information which could obviate localized morphological variations. We measured hippocampal neuroanatomical asymmetry from MR images of 417 subjects as a surrogate measurement of brain atrophy, anticipating that it would have a better sensitivity than volumetric information regarding differences between healthy controls and subjects with AD. Asymmetry was defined in terms of the overlapping voxels between left and right hippocampi after a co-registration process. We found a significant difference (p-value = 0.007) in discrimination power between hippocampal volume and neuroanatomical asymmetry. This result suggests that neuroanatomical asymmetry should be further studied to determine whether it could replace the current brain atrophy biomarker.",

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note = "Funding Information: This work was partially supported by the Consejo Nacional de Ciencia y Tecnolog{\'i}a (CONACYT) and by Universidad de Monterrey through the Fondo de Fomentos a la Investigaci{\'o}n Grant. Publisher Copyright: {\textcopyright} 2019 SPIE. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

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Martinez-Torteya, A, Rivera-Davila, M, Celaya-Padilla, JM, Tamez-Peña, JG & Rodríguez-Cantú, FE 2019, Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. in B Gimi & A Krol (eds), Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2019 edn, vol. 10953, 109530U, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10953, SPIE. https://doi.org/10.1117/12.2514771

Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. / Martinez-Torteya, Antonio; Rivera-Davila, Monica; Celaya-Padilla, José M. et al.
Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging. ed. / Barjor Gimi; Andrzej Krol. Vol. 10953 2019. ed. SPIE, 2019. 109530U (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10953).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Rodríguez-Cantú, Félix E.

N1 - Funding Information: This work was partially supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT) and by Universidad de Monterrey through the Fondo de Fomentos a la Investigación Grant. Publisher Copyright: © 2019 SPIE. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/3/15

Y1 - 2019/3/15

N2 - Alzheimer's disease (AD) is the most common form of dementia, and an accurate diagnosis confers many clinical research and patient care benefits. The current research-setting criteria needs to consider at least one supportive biomarker before diagnosing a subject with AD, and brain atrophy measured using structural magnetic resonance is one of them. Yet, brain atrophy is currently defined using only volumetric information which could obviate localized morphological variations. We measured hippocampal neuroanatomical asymmetry from MR images of 417 subjects as a surrogate measurement of brain atrophy, anticipating that it would have a better sensitivity than volumetric information regarding differences between healthy controls and subjects with AD. Asymmetry was defined in terms of the overlapping voxels between left and right hippocampi after a co-registration process. We found a significant difference (p-value = 0.007) in discrimination power between hippocampal volume and neuroanatomical asymmetry. This result suggests that neuroanatomical asymmetry should be further studied to determine whether it could replace the current brain atrophy biomarker.

AB - Alzheimer's disease (AD) is the most common form of dementia, and an accurate diagnosis confers many clinical research and patient care benefits. The current research-setting criteria needs to consider at least one supportive biomarker before diagnosing a subject with AD, and brain atrophy measured using structural magnetic resonance is one of them. Yet, brain atrophy is currently defined using only volumetric information which could obviate localized morphological variations. We measured hippocampal neuroanatomical asymmetry from MR images of 417 subjects as a surrogate measurement of brain atrophy, anticipating that it would have a better sensitivity than volumetric information regarding differences between healthy controls and subjects with AD. Asymmetry was defined in terms of the overlapping voxels between left and right hippocampi after a co-registration process. We found a significant difference (p-value = 0.007) in discrimination power between hippocampal volume and neuroanatomical asymmetry. This result suggests that neuroanatomical asymmetry should be further studied to determine whether it could replace the current brain atrophy biomarker.

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PB - SPIE

ER -

Martinez-Torteya A, Rivera-Davila M, Celaya-Padilla JM, Tamez-Peña JG, Rodríguez-Cantú FE. Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. In Gimi B, Krol A, editors, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging. 2019 ed. Vol. 10953. SPIE. 2019. 109530U. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2514771

Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease

Abstract

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Bibliographical note

All Science Journal Classification (ASJC) codes

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