Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease

Antonio Martinez-Torteya, Monica Rivera-Davila, José M. Celaya-Padilla, José G. Tamez-Peña, Félix E. Rodríguez-Cantú

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Alzheimer's disease (AD) is the most common form of dementia, and an accurate diagnosis confers many clinical research and patient care benefits. The current research-setting criteria needs to consider at least one supportive biomarker before diagnosing a subject with AD, and brain atrophy measured using structural magnetic resonance is one of them. Yet, brain atrophy is currently defined using only volumetric information which could obviate localized morphological variations. We measured hippocampal neuroanatomical asymmetry from MR images of 417 subjects as a surrogate measurement of brain atrophy, anticipating that it would have a better sensitivity than volumetric information regarding differences between healthy controls and subjects with AD. Asymmetry was defined in terms of the overlapping voxels between left and right hippocampi after a co-registration process. We found a significant difference (p-value = 0.007) in discrimination power between hippocampal volume and neuroanatomical asymmetry. This result suggests that neuroanatomical asymmetry should be further studied to determine whether it could replace the current brain atrophy biomarker. © 2019 SPIE.
Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume10953
Edition2019
ISBN (Electronic)978-151062553-2
DOIs
Publication statusPublished - 15 Mar 2019

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Atrophy
Alzheimer Disease
Brain
Biomarkers
Research
Dementia
Hippocampus
Patient Care
Healthy Volunteers
Magnetic Resonance Spectroscopy

Cite this

Martinez-Torteya, A., Rivera-Davila, M., Celaya-Padilla, J. M., Tamez-Peña, J. G., & Rodríguez-Cantú, F. E. (2019). Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2019 ed., Vol. 10953). [109530U] SPIE. https://doi.org/10.1117/12.2514771
Martinez-Torteya, Antonio ; Rivera-Davila, Monica ; Celaya-Padilla, José M. ; Tamez-Peña, José G. ; Rodríguez-Cantú, Félix E. / Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 10953 2019. ed. SPIE, 2019.
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Martinez-Torteya, A, Rivera-Davila, M, Celaya-Padilla, JM, Tamez-Peña, JG & Rodríguez-Cantú, FE 2019, Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2019 edn, vol. 10953, 109530U, SPIE. https://doi.org/10.1117/12.2514771

Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. / Martinez-Torteya, Antonio; Rivera-Davila, Monica; Celaya-Padilla, José M.; Tamez-Peña, José G.; Rodríguez-Cantú, Félix E.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 10953 2019. ed. SPIE, 2019. 109530U.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Martinez-Torteya A, Rivera-Davila M, Celaya-Padilla JM, Tamez-Peña JG, Rodríguez-Cantú FE. Measuring hippocampal neuroanatomical asymmetry to better diagnose Alzheimer's disease. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2019 ed. Vol. 10953. SPIE. 2019. 109530U https://doi.org/10.1117/12.2514771