Mapeo por inmunofluorescencia para el diagnóstico de epidermólisis ampollosa congénita

R. Cepeda-Valdés, G. Pohla-Gubo, J. R. Borbolla-Escoboza, O. Barboza-Quintana, J. Ancer-Rodríguez, H. Hintner, J. C. Salas-Alanis

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17 Citations (Scopus)

Abstract

The tools for diagnosis of epidermolysis bullosa have advanced greatly since Hintner's group introduced antigen mapping as a diagnostic test for this family of genodermatoses. Monoclonal or polyclonal antibodies raised against some of the specific proteins found in the epidermis and basement membrane of the epidermis have allowed 4 types of epidermolysis bullosa de be identified and all variants to be classified. When a newborn baby presents with blisters, many conditions are implicated in the differential diagnosis. Examination under an optical microscope can suggest epidermolysis bullosa, but immunofluorescence mapping and electron microscopy are required for confirmation of the diagnosis and further classification of congenital epidermolysis bullosa. This article explains the importance of immunofluorescence antigen mapping and describes the methods employed for classification and subclassification of epidermolysis bullosa.

Original languageSpanish
Pages (from-to)673-682
Number of pages10
JournalActas Dermo-Sifiliograficas
Volume101
Issue number8
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

Bibliographical note

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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