TY - JOUR
T1 - Low Serum Magnesium Levels and Its Association with High Blood Pressure in Children
AU - Network of Childhood Obesity of the Mexican Social Security Institute
AU - Guerrero-Romero, Fernando
AU - Rodríguez-Morán, Martha
AU - Hernández-Ronquillo, Gabriela
AU - Gómez-Díaz, Rita
AU - Pizano-Zarate, María L.
AU - Wacher, Niels H.
AU - Mondragón-González, Rafael
AU - Simental-Mendia, Luis E.
AU - Salinas Martínez, Ana María
AU - Álvarez Villaseñor, Andrea Socorro
AU - Gómez García, Anel
AU - Pineda Carranza, Antonio
AU - González Pérez, Brian
AU - Medina Escobedo, Carolina Elizabeth
AU - Rodríguez, Cecilia Colunga
AU - López Campos, Celsa
AU - López Morales, Cruz Mónica
AU - Almeida Gutiérrez, Eduardo
AU - Garrido Magaña, Eulalia Piedad
AU - Nava Ayala, Flor Araceli
AU - González Salazar, Francisco
AU - Borrayo Sánchez, Gabriela
AU - Escudero Lourdes, Gabriela
AU - Sosa Bustamante, Gloria Patricia
AU - Ruíz Vivanco, Guadalupe
AU - Vargas, Haydé Rosas
AU - Sánchez Nuncio, Héctor Rafael
AU - Isordia Salas, Irma
AU - Nares Cisneros, Jesus
AU - Peralta Romero, José De Jesús
AU - Paniagua Sierra, José Ramón
AU - De La Garza, Laura Hermila
AU - Ruíz Charles, Ma Guadalupe
AU - León Mazón, Marco Antonio
AU - López Alarcón, Mardia
AU - De Socorro Romero Figueroa, María
AU - Haro Acosta, María Elena
AU - Furuya Meguro, Maria Elena Y.
AU - Galván Plata, María Eugenia
AU - Jiménez Baéz, María Valeria
AU - Dávila Rodríguez, Martha I.
AU - Villasis Keever, Miguel Angel
AU - Cruz López, Miguel
AU - Huerta Orea, Mirna Aurea
AU - Sánchez Hernández, Norma Alicia
AU - Hernández Herrera, Ricardo Jorge
AU - Pérez Fuentes, Ricardo
AU - Salas Flores, Ricardo
AU - Ortega Cortés, Rosa
AU - Lazcano, Sonia
N1 - Funding Information:
Supported by the Mexican Social Security Institute Foundation, California. The authors declare no conflicts of interest.
Publisher Copyright:
© 2016 Elsevier Inc.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - OBJECTIVE: To evaluate the association of hypomagnesemia with prehypertension (preHTN) and hypertension in children.STUDY DESIGN: A total of 3954 apparently healthy Mexican children were enrolled in a cross-sectional study. Exclusion criteria were type 2 diabetes; hepatic, renal, or endocrine disease; impaired fasting glucose; chronic diarrhea; and intake of vitamins or magnesium supplements in the previous 6 months. preHTN was defined by systolic and/or diastolic blood pressure ≥90th to <95th percentile and hypertension by systolic and/or diastolic blood pressure ≥95th percentile, according to age, sex, and height percentile. Hypomagnesemia was defined by serum magnesium concentration <1.8 mg/dL (<0.74 mmol/L). To control for potential sources of bias related to age, participants were allocated into 2 groups, aged 6-10 years and 11-15 years.RESULTS: The prevalence of preHTN and hypertension was 12.2% and 6.4%, respectively, in children aged 6-10 years and 13.9% and 10.6% in those aged 11-15 years. Hypomagnesemia was identified in 59 children with preHTN (27.3%) and 52 (45.6%) with hypertension in the 6-10 year age group, and in 115 children with preHTN (36.0%) and 109 (49.6%) with hypertension in the 11-15 year age group. Adjusted multiple logistic regression analysis showed that in children in both age groups, hypomagnesemia was associated with both preHTN (6-10 years: OR, 2.18, P < .0005; 11-15 years: OR, 1.38, P = .018) and hypertension (6-10 years: OR, 4.87, P < .0005; 11-15 years: OR, 1.83, P = .0002).CONCLUSION: Our results indicate that serum magnesium level <1.8 mg/dL is significantly associated with preHTN and hypertension in apparently healthy children.
AB - OBJECTIVE: To evaluate the association of hypomagnesemia with prehypertension (preHTN) and hypertension in children.STUDY DESIGN: A total of 3954 apparently healthy Mexican children were enrolled in a cross-sectional study. Exclusion criteria were type 2 diabetes; hepatic, renal, or endocrine disease; impaired fasting glucose; chronic diarrhea; and intake of vitamins or magnesium supplements in the previous 6 months. preHTN was defined by systolic and/or diastolic blood pressure ≥90th to <95th percentile and hypertension by systolic and/or diastolic blood pressure ≥95th percentile, according to age, sex, and height percentile. Hypomagnesemia was defined by serum magnesium concentration <1.8 mg/dL (<0.74 mmol/L). To control for potential sources of bias related to age, participants were allocated into 2 groups, aged 6-10 years and 11-15 years.RESULTS: The prevalence of preHTN and hypertension was 12.2% and 6.4%, respectively, in children aged 6-10 years and 13.9% and 10.6% in those aged 11-15 years. Hypomagnesemia was identified in 59 children with preHTN (27.3%) and 52 (45.6%) with hypertension in the 6-10 year age group, and in 115 children with preHTN (36.0%) and 109 (49.6%) with hypertension in the 11-15 year age group. Adjusted multiple logistic regression analysis showed that in children in both age groups, hypomagnesemia was associated with both preHTN (6-10 years: OR, 2.18, P < .0005; 11-15 years: OR, 1.38, P = .018) and hypertension (6-10 years: OR, 4.87, P < .0005; 11-15 years: OR, 1.83, P = .0002).CONCLUSION: Our results indicate that serum magnesium level <1.8 mg/dL is significantly associated with preHTN and hypertension in apparently healthy children.
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UR - https://www.mendeley.com/catalogue/bd55bbd1-dc40-3e82-b6a9-43853b220cd2/
U2 - 10.1016/j.jpeds.2015.09.050
DO - 10.1016/j.jpeds.2015.09.050
M3 - Article
C2 - 26490130
AN - SCOPUS:84955744613
SN - 0022-3476
VL - 168
SP - 93-98.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -
