Low Serum Magnesium Levels and Its Association with High Blood Pressure in Children

Network of Childhood Obesity of the Mexican Social Security Institute

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective To evaluate the association of hypomagnesemia with prehypertension (preHTN) and hypertension in children. Study design A total of 3954 apparently healthy Mexican children were enrolled in a cross-sectional study. Exclusion criteria were type 2 diabetes; hepatic, renal, or endocrine disease; impaired fasting glucose; chronic diarrhea; and intake of vitamins or magnesium supplements in the previous 6 months. preHTN was defined by systolic and/or diastolic blood pressure ≥90th to <95th percentile and hypertension by systolic and/or diastolic blood pressure ≥95th percentile, according to age, sex, and height percentile. Hypomagnesemia was defined by serum magnesium concentration <1.8 mg/dL (<0.74 mmol/L). To control for potential sources of bias related to age, participants were allocated into 2 groups, aged 6-10 years and 11-15 years. Results The prevalence of preHTN and hypertension was 12.2% and 6.4%, respectively, in children aged 6-10 years and 13.9% and 10.6% in those aged 11-15 years. Hypomagnesemia was identified in 59 children with preHTN (27.3%) and 52 (45.6%) with hypertension in the 6-10 year age group, and in 115 children with preHTN (36.0%) and 109 (49.6%) with hypertension in the 11-15 year age group. Adjusted multiple logistic regression analysis showed that in children in both age groups, hypomagnesemia was associated with both preHTN (6-10 years: OR, 2.18, P <.0005; 11-15 years: OR, 1.38, P =.018) and hypertension (6-10 years: OR, 4.87, P <.0005; 11-15 years: OR, 1.83, P =.0002). Conclusion Our results indicate that serum magnesium level <1.8 mg/dL is significantly associated with preHTN and hypertension in apparently healthy children.

Original languageEnglish
Pages (from-to)93-98.e1
JournalJournal of Pediatrics
Volume168
DOIs
Publication statusPublished - 1 Jan 2016

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Prehypertension
Magnesium
Hypertension
Serum
Blood Pressure
Age Groups
Endocrine System Diseases
Vitamins
Type 2 Diabetes Mellitus
Diarrhea
Fasting
Cross-Sectional Studies
Logistic Models
Regression Analysis
Kidney
Glucose
Liver

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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Network of Childhood Obesity of the Mexican Social Security Institute. / Low Serum Magnesium Levels and Its Association with High Blood Pressure in Children. In: Journal of Pediatrics. 2016 ; Vol. 168. pp. 93-98.e1.
@article{d94620698ac842fcae094e81d3bc9943,
title = "Low Serum Magnesium Levels and Its Association with High Blood Pressure in Children",
abstract = "Objective To evaluate the association of hypomagnesemia with prehypertension (preHTN) and hypertension in children. Study design A total of 3954 apparently healthy Mexican children were enrolled in a cross-sectional study. Exclusion criteria were type 2 diabetes; hepatic, renal, or endocrine disease; impaired fasting glucose; chronic diarrhea; and intake of vitamins or magnesium supplements in the previous 6 months. preHTN was defined by systolic and/or diastolic blood pressure ≥90th to <95th percentile and hypertension by systolic and/or diastolic blood pressure ≥95th percentile, according to age, sex, and height percentile. Hypomagnesemia was defined by serum magnesium concentration <1.8 mg/dL (<0.74 mmol/L). To control for potential sources of bias related to age, participants were allocated into 2 groups, aged 6-10 years and 11-15 years. Results The prevalence of preHTN and hypertension was 12.2{\%} and 6.4{\%}, respectively, in children aged 6-10 years and 13.9{\%} and 10.6{\%} in those aged 11-15 years. Hypomagnesemia was identified in 59 children with preHTN (27.3{\%}) and 52 (45.6{\%}) with hypertension in the 6-10 year age group, and in 115 children with preHTN (36.0{\%}) and 109 (49.6{\%}) with hypertension in the 11-15 year age group. Adjusted multiple logistic regression analysis showed that in children in both age groups, hypomagnesemia was associated with both preHTN (6-10 years: OR, 2.18, P <.0005; 11-15 years: OR, 1.38, P =.018) and hypertension (6-10 years: OR, 4.87, P <.0005; 11-15 years: OR, 1.83, P =.0002). Conclusion Our results indicate that serum magnesium level <1.8 mg/dL is significantly associated with preHTN and hypertension in apparently healthy children.",
author = "{Network of Childhood Obesity of the Mexican Social Security Institute} and Fernando Guerrero-Romero and Martha Rodr{\'i}guez-Mor{\'a}n and Gabriela Hern{\'a}ndez-Ronquillo and Rita G{\'o}mez-D{\'i}az and Pizano-Zarate, {Mar{\'i}a L.} and Wacher, {Niels H.} and Rafael Mondrag{\'o}n-Gonz{\'a}lez and Simental-Mendia, {Luis E.} and {Salinas Mart{\'i}nez}, {Ana Mar{\'i}a} and {{\'A}lvarez Villase{\~n}or}, {Andrea Socorro} and {G{\'o}mez Garc{\'i}a}, Anel and {Pineda Carranza}, Antonio and {Gonz{\'a}lez P{\'e}rez}, Brian and {Medina Escobedo}, {Carolina Elizabeth} and Rodr{\'i}guez, {Cecilia Colunga} and {L{\'o}pez Campos}, Celsa and {L{\'o}pez Morales}, {Cruz M{\'o}nica} and {Almeida Guti{\'e}rrez}, Eduardo and {Garrido Maga{\~n}a}, {Eulalia Piedad} and {Nava Ayala}, {Flor Araceli} and {Gonz{\'a}lez Salazar}, Francisco and {Borrayo S{\'a}nchez}, Gabriela and {Escudero Lourdes}, Gabriela and {Sosa Bustamante}, {Gloria Patricia} and {Ru{\'i}z Vivanco}, Guadalupe and Vargas, {Hayd{\'e} Rosas} and {S{\'a}nchez Nuncio}, {H{\'e}ctor Rafael} and {Isordia Salas}, Irma and {Nares Cisneros}, Jesus and {Peralta Romero}, {Jos{\'e} De Jes{\'u}s} and {Paniagua Sierra}, {Jos{\'e} Ram{\'o}n} and {De La Garza}, {Laura Hermila} and {Ru{\'i}z Charles}, {Ma Guadalupe} and {Le{\'o}n Maz{\'o}n}, {Marco Antonio} and {L{\'o}pez Alarc{\'o}n}, Mardia and {De Socorro Romero Figueroa}, Mar{\'i}a and {Haro Acosta}, {Mar{\'i}a Elena} and {Furuya Meguro}, {Maria Elena Y.} and {Galv{\'a}n Plata}, {Mar{\'i}a Eugenia} and {Jim{\'e}nez Ba{\'e}z}, {Mar{\'i}a Valeria} and {D{\'a}vila Rodr{\'i}guez}, {Martha I.} and {Villasis Keever}, {Miguel Angel} and {Cruz L{\'o}pez}, Miguel and {Huerta Orea}, {Mirna Aurea} and {S{\'a}nchez Hern{\'a}ndez}, {Norma Alicia} and {Hern{\'a}ndez Herrera}, {Ricardo Jorge} and {P{\'e}rez Fuentes}, Ricardo and {Salas Flores}, Ricardo and {Ortega Cort{\'e}s}, Rosa and Sonia Lazcano",
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Network of Childhood Obesity of the Mexican Social Security Institute 2016, 'Low Serum Magnesium Levels and Its Association with High Blood Pressure in Children', Journal of Pediatrics, vol. 168, pp. 93-98.e1. https://doi.org/10.1016/j.jpeds.2015.09.050

Low Serum Magnesium Levels and Its Association with High Blood Pressure in Children. / Network of Childhood Obesity of the Mexican Social Security Institute.

In: Journal of Pediatrics, Vol. 168, 01.01.2016, p. 93-98.e1.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Low Serum Magnesium Levels and Its Association with High Blood Pressure in Children

AU - Network of Childhood Obesity of the Mexican Social Security Institute

AU - Guerrero-Romero, Fernando

AU - Rodríguez-Morán, Martha

AU - Hernández-Ronquillo, Gabriela

AU - Gómez-Díaz, Rita

AU - Pizano-Zarate, María L.

AU - Wacher, Niels H.

AU - Mondragón-González, Rafael

AU - Simental-Mendia, Luis E.

AU - Salinas Martínez, Ana María

AU - Álvarez Villaseñor, Andrea Socorro

AU - Gómez García, Anel

AU - Pineda Carranza, Antonio

AU - González Pérez, Brian

AU - Medina Escobedo, Carolina Elizabeth

AU - Rodríguez, Cecilia Colunga

AU - López Campos, Celsa

AU - López Morales, Cruz Mónica

AU - Almeida Gutiérrez, Eduardo

AU - Garrido Magaña, Eulalia Piedad

AU - Nava Ayala, Flor Araceli

AU - González Salazar, Francisco

AU - Borrayo Sánchez, Gabriela

AU - Escudero Lourdes, Gabriela

AU - Sosa Bustamante, Gloria Patricia

AU - Ruíz Vivanco, Guadalupe

AU - Vargas, Haydé Rosas

AU - Sánchez Nuncio, Héctor Rafael

AU - Isordia Salas, Irma

AU - Nares Cisneros, Jesus

AU - Peralta Romero, José De Jesús

AU - Paniagua Sierra, José Ramón

AU - De La Garza, Laura Hermila

AU - Ruíz Charles, Ma Guadalupe

AU - León Mazón, Marco Antonio

AU - López Alarcón, Mardia

AU - De Socorro Romero Figueroa, María

AU - Haro Acosta, María Elena

AU - Furuya Meguro, Maria Elena Y.

AU - Galván Plata, María Eugenia

AU - Jiménez Baéz, María Valeria

AU - Dávila Rodríguez, Martha I.

AU - Villasis Keever, Miguel Angel

AU - Cruz López, Miguel

AU - Huerta Orea, Mirna Aurea

AU - Sánchez Hernández, Norma Alicia

AU - Hernández Herrera, Ricardo Jorge

AU - Pérez Fuentes, Ricardo

AU - Salas Flores, Ricardo

AU - Ortega Cortés, Rosa

AU - Lazcano, Sonia

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objective To evaluate the association of hypomagnesemia with prehypertension (preHTN) and hypertension in children. Study design A total of 3954 apparently healthy Mexican children were enrolled in a cross-sectional study. Exclusion criteria were type 2 diabetes; hepatic, renal, or endocrine disease; impaired fasting glucose; chronic diarrhea; and intake of vitamins or magnesium supplements in the previous 6 months. preHTN was defined by systolic and/or diastolic blood pressure ≥90th to <95th percentile and hypertension by systolic and/or diastolic blood pressure ≥95th percentile, according to age, sex, and height percentile. Hypomagnesemia was defined by serum magnesium concentration <1.8 mg/dL (<0.74 mmol/L). To control for potential sources of bias related to age, participants were allocated into 2 groups, aged 6-10 years and 11-15 years. Results The prevalence of preHTN and hypertension was 12.2% and 6.4%, respectively, in children aged 6-10 years and 13.9% and 10.6% in those aged 11-15 years. Hypomagnesemia was identified in 59 children with preHTN (27.3%) and 52 (45.6%) with hypertension in the 6-10 year age group, and in 115 children with preHTN (36.0%) and 109 (49.6%) with hypertension in the 11-15 year age group. Adjusted multiple logistic regression analysis showed that in children in both age groups, hypomagnesemia was associated with both preHTN (6-10 years: OR, 2.18, P <.0005; 11-15 years: OR, 1.38, P =.018) and hypertension (6-10 years: OR, 4.87, P <.0005; 11-15 years: OR, 1.83, P =.0002). Conclusion Our results indicate that serum magnesium level <1.8 mg/dL is significantly associated with preHTN and hypertension in apparently healthy children.

AB - Objective To evaluate the association of hypomagnesemia with prehypertension (preHTN) and hypertension in children. Study design A total of 3954 apparently healthy Mexican children were enrolled in a cross-sectional study. Exclusion criteria were type 2 diabetes; hepatic, renal, or endocrine disease; impaired fasting glucose; chronic diarrhea; and intake of vitamins or magnesium supplements in the previous 6 months. preHTN was defined by systolic and/or diastolic blood pressure ≥90th to <95th percentile and hypertension by systolic and/or diastolic blood pressure ≥95th percentile, according to age, sex, and height percentile. Hypomagnesemia was defined by serum magnesium concentration <1.8 mg/dL (<0.74 mmol/L). To control for potential sources of bias related to age, participants were allocated into 2 groups, aged 6-10 years and 11-15 years. Results The prevalence of preHTN and hypertension was 12.2% and 6.4%, respectively, in children aged 6-10 years and 13.9% and 10.6% in those aged 11-15 years. Hypomagnesemia was identified in 59 children with preHTN (27.3%) and 52 (45.6%) with hypertension in the 6-10 year age group, and in 115 children with preHTN (36.0%) and 109 (49.6%) with hypertension in the 11-15 year age group. Adjusted multiple logistic regression analysis showed that in children in both age groups, hypomagnesemia was associated with both preHTN (6-10 years: OR, 2.18, P <.0005; 11-15 years: OR, 1.38, P =.018) and hypertension (6-10 years: OR, 4.87, P <.0005; 11-15 years: OR, 1.83, P =.0002). Conclusion Our results indicate that serum magnesium level <1.8 mg/dL is significantly associated with preHTN and hypertension in apparently healthy children.

UR - http://www.scopus.com/inward/record.url?scp=84955744613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955744613&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2015.09.050

DO - 10.1016/j.jpeds.2015.09.050

M3 - Article

VL - 168

SP - 93-98.e1

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -

Network of Childhood Obesity of the Mexican Social Security Institute. Low Serum Magnesium Levels and Its Association with High Blood Pressure in Children. Journal of Pediatrics. 2016 Jan 1;168:93-98.e1. https://doi.org/10.1016/j.jpeds.2015.09.050