Longitudinal gender-specific differences in the conversion from mild cognitive impairment to Alzheimer's disease

Angel G. Cadena-Hernandez, Alejandro I. Trejo-Castro, Jose M. Celaya-Padilla, Jose Tamez-Pena, Antonio Martinez-Torteya

Research output: Contribution to conferencePaper

Abstract

Predicting who will convert from mild cognitive impairment (MCI) to Alzheimer's disease would have large clinical implications, and stratifying this process could enhance its accuracy. This study aimed at identifying features from the Alzheimer's Disease Neuroimaging Initiative database associated with such a conversion whose temporal evolution significantly differs between men and women. We gathered information from 59 women and 109 men who were diagnosed with MCI at baseline and eventually converted to AD. Information included features from laboratory assays, MRI and PET analyses, and neuropsychological tests. Statistical longitudinal models identified features with significant differences in longitudinal behavior between genders. We found 20 features with such differences at either the time at which subjects were first diagnosed with AD or related to the speed at which they evolved. Our results show that the way in which male and female subjects evolve throughout the MCI to AD conversion process is different, hence, predicting who will go through such a conversion could be better predicting by taking into account these differences.

Original languageEnglish
Pages202-205
Number of pages4
DOIs
Publication statusPublished - 6 Apr 2018
Event2018 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2018 -
Duration: 6 Apr 2018 → …

Conference

Conference2018 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2018
Period6/4/18 → …

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Biomedical Engineering
  • Health Informatics

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    Cadena-Hernandez, A. G., Trejo-Castro, A. I., Celaya-Padilla, J. M., Tamez-Pena, J., & Martinez-Torteya, A. (2018). Longitudinal gender-specific differences in the conversion from mild cognitive impairment to Alzheimer's disease. 202-205. Paper presented at 2018 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2018, . https://doi.org/10.1109/BHI.2018.8333404