TY - JOUR
T1 - Liver fibrosis and protection mechanisms action of medicinal plants targeting apoptosis of hepatocytes and hepatic stellate cells
AU - Duval, Florent
AU - Moreno-Cuevas, Jorge E.
AU - González-Garza, Maria Teresa
AU - Rodríguez-Montalvo, Carlos
AU - Cruz-Vega, Delia Elva
PY - 2014
Y1 - 2014
N2 - Following chronic liver injury, hepatocytes undergo apoptosis leading to activation of hepatic stellate cells (HSC). Consequently, activated HSC proliferate and produce excessive extracellular matrix, responsible for the scar formation. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Treatment strategies should take into account the versatility of its pathogenesis and act on all the cell lines involved to reduce liver fibrosis. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. This review will describe the role of hepatocytes and HSC in the pathogenesis of liver fibrosis and detail the mechanisms of modulation of apoptosis of both cell lines by twelve known hepatoprotective plants in order to reduce liver fibrosis.
AB - Following chronic liver injury, hepatocytes undergo apoptosis leading to activation of hepatic stellate cells (HSC). Consequently, activated HSC proliferate and produce excessive extracellular matrix, responsible for the scar formation. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Treatment strategies should take into account the versatility of its pathogenesis and act on all the cell lines involved to reduce liver fibrosis. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. This review will describe the role of hepatocytes and HSC in the pathogenesis of liver fibrosis and detail the mechanisms of modulation of apoptosis of both cell lines by twelve known hepatoprotective plants in order to reduce liver fibrosis.
UR - http://www.scopus.com/inward/record.url?scp=84914680177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84914680177&partnerID=8YFLogxK
U2 - 10.1155/2014/373295
DO - 10.1155/2014/373295
M3 - Review article
AN - SCOPUS:84914680177
VL - 2014
JO - Advances in Pharmacological Sciences
JF - Advances in Pharmacological Sciences
SN - 1687-6334
M1 - 373295
ER -