Leprosy. An update: Definition, pathogenesis, classification, diagnosis, and treatment

K. Eichelmann, S. E. González González, J. C. Salas-Alanis, J. Ocampo-Candiani

Research output: Contribution to journalLiterature review

58 Citations (Scopus)

Abstract

Leprosy is a chronic granulomatous disease caused by the bacillus Mycobacterium leprae. It primarily affects the skin and peripheral nerves and is still endemic in various regions of the world. Clinical presentation depends on the patient's immune status at the time of infection and during the course of the disease. Leprosy is associated with disability and marginalization. Diagnosis is clinical and is made when the patient has at least 1 of the following cardinal signs specified by the World Health Organization: hypopigmented or erythematous macules with sensory loss; thickened peripheral nerves; or positive acid-fast skin smear or skin biopsy with loss of adnexa at affected sites. Leprosy is treated with a multidrug combination of rifampicin, clofazimine, and dapsone. Two main regimens are used depending on whether the patient has paucibacillary or multibacillary disease. © 2011 Elsevier España, S.L. and AEDV. All rights reserved.
Original languageEnglish
Pages (from-to)554-563
Number of pages10
JournalActas Dermo-Sifiliograficas
DOIs
Publication statusPublished - 1 Sep 2013
Externally publishedYes

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Leprosy
Peripheral Nerves
Skin
Clofazimine
Chronic Granulomatous Disease
Mycobacterium leprae
Dapsone
Rifampin
Bacillus
Therapeutics
Biopsy
Acids
Infection

Cite this

Eichelmann, K., González González, S. E., Salas-Alanis, J. C., & Ocampo-Candiani, J. (2013). Leprosy. An update: Definition, pathogenesis, classification, diagnosis, and treatment. Actas Dermo-Sifiliograficas, 554-563. https://doi.org/10.1016/j.ad.2012.03.003
Eichelmann, K. ; González González, S. E. ; Salas-Alanis, J. C. ; Ocampo-Candiani, J. / Leprosy. An update: Definition, pathogenesis, classification, diagnosis, and treatment. In: Actas Dermo-Sifiliograficas. 2013 ; pp. 554-563.
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Eichelmann, K, González González, SE, Salas-Alanis, JC & Ocampo-Candiani, J 2013, 'Leprosy. An update: Definition, pathogenesis, classification, diagnosis, and treatment', Actas Dermo-Sifiliograficas, pp. 554-563. https://doi.org/10.1016/j.ad.2012.03.003

Leprosy. An update: Definition, pathogenesis, classification, diagnosis, and treatment. / Eichelmann, K.; González González, S. E.; Salas-Alanis, J. C.; Ocampo-Candiani, J.

In: Actas Dermo-Sifiliograficas, 01.09.2013, p. 554-563.

Research output: Contribution to journalLiterature review

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