Individual response to drug therapy: Bases and study approaches

Rafael Baltazar Reyes Leoń-Cachón, Jorge Ángel Ascacio-Martínez, Hugo Alberto Barrera-Saldaña

Research output: Contribution to journalLiterature review

10 Citations (Scopus)

Abstract

Genomic variation largely explains the differences in an individual's response to drug treatments. A field of genomic medicine focuses on the identification of genetic polymorphisms and gene mutations involved in the development and progression of disease. Another part focuses on the development of genetic tests to accompany medical prescriptions, to predict how certain patients respond to therapy with a given pharmacological agent. The field of predicting responses to drugs has different strategies and methods, among which we find: the use of liver microsomes, cell models, monitoring of probe drugs, assays with recombinant proteins and recently the use of microarray platforms or DNAchips.
Original languageEnglish
Pages (from-to)364-376
Number of pages13
JournalRevista de Investigacion Clinica
Publication statusPublished - 1 Jul 2012
Externally publishedYes

Fingerprint

Drug Therapy
Drug Monitoring
Liver Microsomes
Genetic Polymorphisms
Recombinant Proteins
Individuality
Pharmaceutical Preparations
Prescriptions
Disease Progression
Medicine
Pharmacology
Mutation
Therapeutics
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Leoń-Cachón, Rafael Baltazar Reyes ; Ascacio-Martínez, Jorge Ángel ; Barrera-Saldaña, Hugo Alberto. / Individual response to drug therapy: Bases and study approaches. In: Revista de Investigacion Clinica. 2012 ; pp. 364-376.
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Individual response to drug therapy: Bases and study approaches. / Leoń-Cachón, Rafael Baltazar Reyes; Ascacio-Martínez, Jorge Ángel; Barrera-Saldaña, Hugo Alberto.

In: Revista de Investigacion Clinica, 01.07.2012, p. 364-376.

Research output: Contribution to journalLiterature review

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JO - Revista de Investigacion Clinica

JF - Revista de Investigacion Clinica

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