Incremento de las citoquinas proteína quimiotáctica de monocitos-1 (MCP-1) y proteína inflamatoria macrofágica-1β (MIP-1β) en líquido cefalorraquídeo de pacientes con esclerosis lateral amiotrófica

Translated title of the contribution: Increased cerebrospinal fluid levels of cytokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in patients with amyotrophic lateral sclerosis

H. R. Martínez, C. E. Escamilla-Ocañas, C. R. Camara-Lemarroy, M. T. González-Garza, J. Moreno-Cuevas, M. A. García Sarreón

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Introduction: Neuroinflammation has recently been described in amyotrophic lateral sclerosis (ALS). However, the precise role of such proinflammatory cytokines as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in ALS has not yet been determined. In this study, we determined cerebrospinal fluid (CSF) MCP-1 and MIP-1β levels and assessed their association with the duration and severity of ALS. Methods: Concentrations of MCP-1 and MIP-1β were determined in the CSF of 77 patients diagnosed with ALS and 13 controls. Cytokine levels were analysed in relation to ALS duration (<. 12. months vs. >. 12. months) and severity (<. 30. points vs. >. 30. points on the ALS Functional Rating Scale administered at hospital admission). Results: Higher CSF MIP-1β (10.68. pg/mL vs. 4.69. pg/mL, P <. .0001) and MCP-1 (234.89. pg/mL vs. 160.95. pg/mL, P = .011) levels were found in the 77 patients with ALS compared to controls. There were no differences in levels of either cytokine in relation to disease duration or severity. However, we did observe a significant positive correlation between MIP-1β and MCP-1 in patients with ALS. Conclusions: The increase in MIP-1β and MCP-1 levels suggests that these cytokines may have a synergistic effect on ALS pathogenesis. However, in our cohort, no association was found with either the duration or the clinical severity of the disease.

Translated title of the contributionIncreased cerebrospinal fluid levels of cytokines monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) in patients with amyotrophic lateral sclerosis
Original languageSpanish
Pages (from-to)165-169
Number of pages5
JournalNeurologia
Volume35
Issue number3
DOIs
Publication statusPublished - Apr 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 Sociedad Española de Neurología

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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