In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts

Alexandra M. Montoya; Carolina E. Luna-Rodríguez; Gabriela Gracia-Robles; Olga C. Rojas; Gloria M. González

doi:10.1007/s00203-019-01684-2

In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts

Alexandra M. Montoya, Carolina E. Luna-Rodríguez, Gabriela Gracia-Robles, Olga C. Rojas, Gloria M. González

Departamento de Ciencias Básicas

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).

Original language	English
Pages (from-to)	1147-1149
Number of pages	3
Journal	Archives of Microbiology
Volume	201
Issue number	8
DOIs	https://doi.org/10.1007/s00203-019-01684-2
Publication status	Published - 1 Oct 2019

Bibliographical note

Funding Information:
This study was supported by Programa de Apoyo a la Investigación Científica y Tecnológica (PAICyT) (no. SA-1115-15). We thank Sergio Lozano-Rodriguez, M. D., of the “Dr. José E. González” University Hospital (Monterrey, Mexico) for his review of the manuscript prior to submission.

Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

All Science Journal Classification (ASJC) codes

Microbiology
Biochemistry
Molecular Biology
Genetics

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title = "In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts",

abstract = "Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).",

author = "Montoya, {Alexandra M.} and Luna-Rodr{\'i}guez, {Carolina E.} and Gabriela Gracia-Robles and Rojas, {Olga C.} and Gonz{\'a}lez, {Gloria M.}",

note = "Funding Information: This study was supported by Programa de Apoyo a la Investigaci{\'o}n Cient{\'i}fica y Tecnol{\'o}gica (PAICyT) (no. SA-1115-15). We thank Sergio Lozano-Rodriguez, M. D., of the “Dr. Jos{\'e} E. Gonz{\'a}lez” University Hospital (Monterrey, Mexico) for his review of the manuscript prior to submission. Publisher Copyright: {\textcopyright} 2019, Springer-Verlag GmbH Germany, part of Springer Nature.",

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doi = "10.1007/s00203-019-01684-2",

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AU - Montoya, Alexandra M.

AU - Luna-Rodríguez, Carolina E.

AU - Gracia-Robles, Gabriela

AU - Rojas, Olga C.

AU - González, Gloria M.

N1 - Funding Information: This study was supported by Programa de Apoyo a la Investigación Científica y Tecnológica (PAICyT) (no. SA-1115-15). We thank Sergio Lozano-Rodriguez, M. D., of the “Dr. José E. González” University Hospital (Monterrey, Mexico) for his review of the manuscript prior to submission. Publisher Copyright: © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2019/10/1

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N2 - Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).

AB - Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).

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In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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