In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts

Alexandra M. Montoya, Carolina E. Luna-Rodríguez, Gabriela Gracia-Robles, Olga C. Rojas, Gloria M. González

Research output: Contribution to journalArticle

Abstract

Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).
Original languageEnglish
Pages (from-to)1147-1149
Number of pages3
JournalArchives of Microbiology
Volume201
Issue number8
DOIs
Publication statusPublished - 1 Oct 2019

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Yeast
Yeasts
Echinocandins
Aspartic Acid Proteases
Hemolysin Proteins
Phospholipases
Fluconazole
Candida
Amphotericin B
Virulence Factors
Pathogens
Esterases
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Montoya, Alexandra M. ; Luna-Rodríguez, Carolina E. ; Gracia-Robles, Gabriela ; Rojas, Olga C. ; González, Gloria M. / In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts. In: Archives of Microbiology. 2019 ; Vol. 201, No. 8. pp. 1147-1149.
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Montoya, AM, Luna-Rodríguez, CE, Gracia-Robles, G, Rojas, OC & González, GM 2019, 'In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts', Archives of Microbiology, vol. 201, no. 8, pp. 1147-1149. https://doi.org/10.1007/s00203-019-01684-2

In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts. / Montoya, Alexandra M.; Luna-Rodríguez, Carolina E.; Gracia-Robles, Gabriela; Rojas, Olga C.; González, Gloria M.

In: Archives of Microbiology, Vol. 201, No. 8, 01.10.2019, p. 1147-1149.

Research output: Contribution to journalArticle

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