Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).
All Science Journal Classification (ASJC) codes
- Molecular Biology
Montoya, A. M., Luna-Rodríguez, C. E., Gracia-Robles, G., Rojas, O. C., & González, G. M. (2019). In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts. Archives of Microbiology, 201(8), 1147-1149. https://doi.org/10.1007/s00203-019-01684-2