In vitro lytic activity and antifungal susceptibility of infrequently isolated yeasts

Alexandra M. Montoya, Carolina E. Luna-Rodríguez, Gabriela Gracia-Robles, Olga C. Rojas, Gloria M. González

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Non-albicans Candida species have acquired relevance in the last decades as a cause of serious disease. The virulence factors and antifungal susceptibility of these rare pathogens remain largely unrecognized. We examined a total of 50 yeast isolates corresponding to 11 different infrequently isolated yeast species for their in vitro enzymatic profile and susceptibility pattern as first-line antifungals. We found aspartyl protease activity for 100% of the isolates tested as well as variable DNAse, hemolysin, phospholipase and esterase activities. All strains had low MICs for amphotericin B and showed a variable response to fluconazole (0.125–32 µg/mL) and the echinocandins tested (0.25–> 8 µg/mL).
Original languageEnglish
Pages (from-to)1147-1149
Number of pages3
JournalArchives of Microbiology
Issue number8
Publication statusPublished - 1 Oct 2019

Bibliographical note

Funding Information:
This study was supported by Programa de Apoyo a la Investigación Científica y Tecnológica (PAICyT) (no. SA-1115-15). We thank Sergio Lozano-Rodriguez, M. D., of the “Dr. José E. González” University Hospital (Monterrey, Mexico) for his review of the manuscript prior to submission.

Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Biochemistry
  • Molecular Biology
  • Genetics


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