Background: Sertraline (SRT) is an antidepressant that has proven its activity in vitro against Cryptococcus, Coccidioides, Trichosporon and other fungi. Disseminated sporotrichosis, although rare, has a high mortality and its treatment is difficult and prolonged, often relying in combining two or more antifungals. Aims: In our study we evaluate the antifungal activity of SRT, alone and in combination with itraconazole (ITC), voriconazole (VRC) and amphotericin B (AMB), against 15 clinical isolates of Sporothrix schenckii. Methods: We used the broth microdilution method as described by the CLSI to test the susceptibility to antifungals, and the checkerboard microdilution method to evaluate drug interactions. Results: The minimum inhibitory concentration (MIC) with SRT was in the range of 4–8 μg/ml, while for AMB, VRC and ITC were 0.5–4 μg/ml, 0.5–8 μg/ml and 0.125–2 μg/ml, respectively. In addition, SRT showed synergy with ITC in one strain, mainly additivity with VRC, and indifference with AMB in others. Conclusions: The MIC values with SRT for the isolates studied show the potential role of this drug as an adjuvant in the treatment of sporotrichosis, especially in disseminated or complicated cases.
|Translated title of the contribution||In vitro inhibitory activity of sertraline against clinical isolates of Sporothrix schenckii|
|Number of pages||3|
|Journal||Revista Iberoamericana de Micologia|
|Early online date||3 Jun 2019|
|Publication status||Published - 1 Jul 2019|
Bibliographical noteFunding Information:
This work was supported by internal resources of the Department of Microbiology, School of Medicine, UANL .
This work was supported by internal resources of the Department of Microbiology, School of Medicine, UANL.
This work was supported by internal resources of the Department of Microbiology, School of Medicine, UANL. Special thanks to Christian L. Campos Cortés, M.Sc. for her technical assistance.
© 2019 Asociación Española de Micología
All Science Journal Classification (ASJC) codes
- Infectious Diseases