Actividad inhibitoria in vitro de la sertralina frente a aislamientos clínicos de Sporothrix schenckii

Translated title of the contribution: In vitro inhibitory activity of sertraline against clinical isolates of Sporothrix schenckii

Olga Carolina Rojas García, Hiram Villanueva Lozano, Rogelio de J. Treviño Rangel, Ricardo Téllez-Marroquín, Alexandro Bonifaz, Pedro A. Hernández Rodríguez, Gloria María González

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Abstract

Background: Sertraline (SRT) is an antidepressant that has proven its activity in vitro against Cryptococcus, Coccidioides, Trichosporon and other fungi. Disseminated sporotrichosis, although rare, has a high mortality and its treatment is difficult and prolonged, often relying in combining two or more antifungals. Aims: In our study we evaluate the antifungal activity of SRT, alone and in combination with itraconazole (ITC), voriconazole (VRC) and amphotericin B (AMB), against 15 clinical isolates of Sporothrix schenckii. Methods: We used the broth microdilution method as described by the CLSI to test the susceptibility to antifungals, and the checkerboard microdilution method to evaluate drug interactions. Results: The minimum inhibitory concentration (MIC) with SRT was in the range of 4–8 μg/ml, while for AMB, VRC and ITC were 0.5–4 μg/ml, 0.5–8 μg/ml and 0.125–2 μg/ml, respectively. In addition, SRT showed synergy with ITC in one strain, mainly additivity with VRC, and indifference with AMB in others. Conclusions: The MIC values with SRT for the isolates studied show the potential role of this drug as an adjuvant in the treatment of sporotrichosis, especially in disseminated or complicated cases.

Translated title of the contributionIn vitro inhibitory activity of sertraline against clinical isolates of Sporothrix schenckii
Original languageSpanish
Pages (from-to)139-141
Number of pages3
JournalRevista Iberoamericana de Micologia
Volume36
Issue number3
Early online date3 Jun 2019
DOIs
Publication statusPublished - 1 Jul 2019

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases

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    Rojas García, O. C., Villanueva Lozano, H., Treviño Rangel, R. D. J., Téllez-Marroquín, R., Bonifaz, A., Hernández Rodríguez, P. A., & González, G. M. (2019). Actividad inhibitoria in vitro de la sertralina frente a aislamientos clínicos de Sporothrix schenckii. Revista Iberoamericana de Micologia, 36(3), 139-141. https://doi.org/10.1016/j.riam.2019.01.004