In vitro effects of ivermectin upon trichomonas vaginalis trophozoites

Francisco González-Salazar; Benito D. Mata-Cárdenas; Gerardo Rivera Silva; Jesús N. Garza-González; Elva I. Cortes-Gutiérrez; Javier Vargas-Villarreal

In vitro effects of ivermectin upon trichomonas vaginalis trophozoites

Francisco González-Salazar, Benito D. Mata-Cárdenas, Gerardo Rivera Silva, Jesús N. Garza-González, Elva I. Cortes-Gutiérrez, Javier Vargas-Villarreal

Research output: Contribution to journal › Article › peer-review

Abstract

Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.

Original language	English
Pages (from-to)	156-158
Number of pages	3
Journal	Latin American Journal of Pharmacy
Volume	31
Issue number	1
Publication status	Published - 30 Apr 2012

All Science Journal Classification (ASJC) codes

Pharmaceutical Science
Drug Discovery

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title = "In vitro effects of ivermectin upon trichomonas vaginalis trophozoites",

abstract = "Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.",

author = "Francisco Gonz{\'a}lez-Salazar and Mata-C{\'a}rdenas, {Benito D.} and {Rivera Silva}, Gerardo and Garza-Gonz{\'a}lez, {Jes{\'u}s N.} and Cortes-Guti{\'e}rrez, {Elva I.} and Javier Vargas-Villarreal",

year = "2012",

month = apr,

day = "30",

language = "English",

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pages = "156--158",

journal = "Acta Farmaceutica Bonaerense",

issn = "0326-2383",

publisher = "Colegio de Farmaceuticos de la Provincia de Buenos Aires",

number = "1",

}

In vitro effects of ivermectin upon trichomonas vaginalis trophozoites. / González-Salazar, Francisco; Mata-Cárdenas, Benito D.; Rivera Silva, Gerardo; Garza-González, Jesús N.; Cortes-Gutiérrez, Elva I.; Vargas-Villarreal, Javier.

In: Latin American Journal of Pharmacy, Vol. 31, No. 1, 30.04.2012, p. 156-158.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - In vitro effects of ivermectin upon trichomonas vaginalis trophozoites

AU - González-Salazar, Francisco

AU - Mata-Cárdenas, Benito D.

AU - Rivera Silva, Gerardo

AU - Garza-González, Jesús N.

AU - Cortes-Gutiérrez, Elva I.

AU - Vargas-Villarreal, Javier

PY - 2012/4/30

Y1 - 2012/4/30

N2 - Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.

AB - Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.

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