TY - JOUR
T1 - In vitro effects of ivermectin upon trichomonas vaginalis trophozoites
AU - González-Salazar, Francisco
AU - Mata-Cárdenas, Benito D.
AU - Rivera Silva, Gerardo
AU - Garza-González, Jesús N.
AU - Cortes-Gutiérrez, Elva I.
AU - Vargas-Villarreal, Javier
PY - 2012/4/30
Y1 - 2012/4/30
N2 - Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.
AB - Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.
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M3 - Article
VL - 31
SP - 156
EP - 158
JO - Acta Farmaceutica Bonaerense
JF - Acta Farmaceutica Bonaerense
SN - 0326-2383
IS - 1
ER -
