In vitro effects of ivermectin upon trichomonas vaginalis trophozoites

Francisco González-Salazar; Benito D. Mata-Cárdenas; Gerardo Rivera Silva; Jesús N. Garza-González; Elva I. Cortes-Gutiérrez; Javier Vargas-Villarreal

In vitro effects of ivermectin upon trichomonas vaginalis trophozoites

Francisco González-Salazar, Benito D. Mata-Cárdenas, Gerardo Rivera Silva, Jesús N. Garza-González, Elva I. Cortes-Gutiérrez, Javier Vargas-Villarreal

Research output: Contribution to journal › Article

Abstract

Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.

Original language	English
Pages (from-to)	156-158
Number of pages	3
Journal	Latin American Journal of Pharmacy
Volume	31
Issue number	1
Publication status	Published - 30 Apr 2012

All Science Journal Classification (ASJC) codes

Pharmaceutical Science
Drug Discovery

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González-Salazar, F., Mata-Cárdenas, B. D., Rivera Silva, G., Garza-González, J. N., Cortes-Gutiérrez, E. I., & Vargas-Villarreal, J. (2012). In vitro effects of ivermectin upon trichomonas vaginalis trophozoites. Latin American Journal of Pharmacy, 31(1), 156-158. https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84860186581&origin=inward

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abstract = "Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.",

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AU - González-Salazar, Francisco

AU - Mata-Cárdenas, Benito D.

AU - Rivera Silva, Gerardo

AU - Garza-González, Jesús N.

AU - Cortes-Gutiérrez, Elva I.

AU - Vargas-Villarreal, Javier

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AB - Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.

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