In vitro effects of ivermectin upon trichomonas vaginalis trophozoites

Francisco González-Salazar, Benito D. Mata-Cárdenas, Gerardo Rivera Silva, Jesús N. Garza-González, Elva I. Cortes-Gutiérrez, Javier Vargas-Villarreal

Research output: Contribution to journalArticle

Abstract

Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.
Original languageEnglish
Pages (from-to)156-158
Number of pages3
JournalLatin American Journal of Pharmacy
Publication statusPublished - 30 Apr 2012

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Trichomonas vaginalis
Ivermectin
Trophozoites
Metronidazole
Trichomonas
Imidazoles
Sexually Transmitted Diseases
In Vitro Techniques
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery

Cite this

González-Salazar, F., Mata-Cárdenas, B. D., Rivera Silva, G., Garza-González, J. N., Cortes-Gutiérrez, E. I., & Vargas-Villarreal, J. (2012). In vitro effects of ivermectin upon trichomonas vaginalis trophozoites. Latin American Journal of Pharmacy, 156-158.
González-Salazar, Francisco ; Mata-Cárdenas, Benito D. ; Rivera Silva, Gerardo ; Garza-González, Jesús N. ; Cortes-Gutiérrez, Elva I. ; Vargas-Villarreal, Javier. / In vitro effects of ivermectin upon trichomonas vaginalis trophozoites. In: Latin American Journal of Pharmacy. 2012 ; pp. 156-158.
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abstract = "Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.",
author = "Francisco Gonz{\'a}lez-Salazar and Mata-C{\'a}rdenas, {Benito D.} and {Rivera Silva}, Gerardo and Garza-Gonz{\'a}lez, {Jes{\'u}s N.} and Cortes-Guti{\'e}rrez, {Elva I.} and Javier Vargas-Villarreal",
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González-Salazar, F, Mata-Cárdenas, BD, Rivera Silva, G, Garza-González, JN, Cortes-Gutiérrez, EI & Vargas-Villarreal, J 2012, 'In vitro effects of ivermectin upon trichomonas vaginalis trophozoites', Latin American Journal of Pharmacy, pp. 156-158.

In vitro effects of ivermectin upon trichomonas vaginalis trophozoites. / González-Salazar, Francisco; Mata-Cárdenas, Benito D.; Rivera Silva, Gerardo; Garza-González, Jesús N.; Cortes-Gutiérrez, Elva I.; Vargas-Villarreal, Javier.

In: Latin American Journal of Pharmacy, 30.04.2012, p. 156-158.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In vitro effects of ivermectin upon trichomonas vaginalis trophozoites

AU - González-Salazar, Francisco

AU - Mata-Cárdenas, Benito D.

AU - Rivera Silva, Gerardo

AU - Garza-González, Jesús N.

AU - Cortes-Gutiérrez, Elva I.

AU - Vargas-Villarreal, Javier

PY - 2012/4/30

Y1 - 2012/4/30

N2 - Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.

AB - Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.

M3 - Article

SP - 156

EP - 158

JO - Acta Farmaceutica Bonaerense

JF - Acta Farmaceutica Bonaerense

SN - 0326-2383

ER -

González-Salazar F, Mata-Cárdenas BD, Rivera Silva G, Garza-González JN, Cortes-Gutiérrez EI, Vargas-Villarreal J. In vitro effects of ivermectin upon trichomonas vaginalis trophozoites. Latin American Journal of Pharmacy. 2012 Apr 30;156-158.