TY - JOUR
T1 - In vitro effects of ivermectin upon trichomonas vaginalis trophozoites
AU - González-Salazar, Francisco
AU - Mata-Cárdenas, Benito D.
AU - Rivera Silva, Gerardo Francisco Javier
AU - Garza-González, Jesús N.
AU - Cortes-Gutiérrez, Elva I.
AU - Vargas-Villarreal, Javier
PY - 2012
Y1 - 2012
N2 - Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.
AB - Trichomoniasis is the most common, curable sexually transmitted disease in the world. The first line treatment of trichomoniasis is metronidazole. Recently, the resistance of T. vaginalis to metronidazole and imidazoles has been shown to increase. Ivermectin is a synthetic machrolid drug with activity versus endo and ectoparasitic organisms. In this assay, was tested the effects of ivermectin on T. vaginalis trophozoites. Ivermectin have anti-parasitic activity upon trichomonas trophozoites. However, the IC 50 of ivermectin against T. vaginalis was high compared with metronidazole.
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M3 - Article
SN - 0326-2383
VL - 31
SP - 156
EP - 158
JO - Latin American Journal of Pharmacy
JF - Latin American Journal of Pharmacy
IS - 1
ER -
