Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats

Carlos Rodrigo Cámara-Lemarroy, Francisco Javier Guzmán-de la Garza, Gabriela Alarcón-Galván, Paula Cordero-Pérez, Linda Muñoz-Espinosa, Liliana Torres-González, Nancy Esthela Fernández-Garza

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Aims: Temporal occlusion of the hepatoduodenal ligament (HDL) is often used during liver surgeries in order to reduce blood loss, resulting in ischemia/reperfusion injury (I/R). The aim of the study was to investigate the effects of atorvastatin (ATOR) on hepatic I/R injury and on serum levels of tumor necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), antithrombin III (ATIII) and intracellular adhesion molecule-1 (ICAM-1). Methods: Liver ischemia was induced in Wistar rats by clamping the HDL for 60 min, followed by either 60 or 180 min reperfusion. Rats received either vehicle or 10 mg/kg ATOR before hepatic I/R. Control group received sham surgery. Livers were examined for histological damage and serum AST, ALT, TNF-α, ET-1, ATIII and ICAM-1 concentrations were measured. Results: After I/R, AST and ALT were significantly elevated, ATIII levels were significantly depleted, both TNF-α and ICAM-1 levels increased and ET-1 was significantly elevated (at 180 min). ATOR pretreatment attenuated these alterations and diminished histological injury scores. Conclusions: Our results show that ATOR protects the liver from I/R injury. © 2014 IMSS.
Original languageEnglish
Pages (from-to)210-216
Number of pages7
JournalArchives of Medical Research
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

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Reperfusion Injury
Wistar Rats
Antithrombin III
Liver
Endothelin-1
Tumor Necrosis Factor-alpha
Ligaments
Wounds and Injuries
Serum
Constriction
Reperfusion
Atorvastatin Calcium
Ischemia
Control Groups

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cámara-Lemarroy, C. R., Guzmán-de la Garza, F. J., Alarcón-Galván, G., Cordero-Pérez, P., Muñoz-Espinosa, L., Torres-González, L., & Fernández-Garza, N. E. (2014). Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats. Archives of Medical Research, 210-216. https://doi.org/10.1016/j.arcmed.2014.02.001
Cámara-Lemarroy, Carlos Rodrigo ; Guzmán-de la Garza, Francisco Javier ; Alarcón-Galván, Gabriela ; Cordero-Pérez, Paula ; Muñoz-Espinosa, Linda ; Torres-González, Liliana ; Fernández-Garza, Nancy Esthela. / Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats. In: Archives of Medical Research. 2014 ; pp. 210-216.
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Cámara-Lemarroy, CR, Guzmán-de la Garza, FJ, Alarcón-Galván, G, Cordero-Pérez, P, Muñoz-Espinosa, L, Torres-González, L & Fernández-Garza, NE 2014, 'Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats', Archives of Medical Research, pp. 210-216. https://doi.org/10.1016/j.arcmed.2014.02.001

Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats. / Cámara-Lemarroy, Carlos Rodrigo; Guzmán-de la Garza, Francisco Javier; Alarcón-Galván, Gabriela; Cordero-Pérez, Paula; Muñoz-Espinosa, Linda; Torres-González, Liliana; Fernández-Garza, Nancy Esthela.

In: Archives of Medical Research, 01.01.2014, p. 210-216.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats

AU - Cámara-Lemarroy, Carlos Rodrigo

AU - Guzmán-de la Garza, Francisco Javier

AU - Alarcón-Galván, Gabriela

AU - Cordero-Pérez, Paula

AU - Muñoz-Espinosa, Linda

AU - Torres-González, Liliana

AU - Fernández-Garza, Nancy Esthela

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background and Aims: Temporal occlusion of the hepatoduodenal ligament (HDL) is often used during liver surgeries in order to reduce blood loss, resulting in ischemia/reperfusion injury (I/R). The aim of the study was to investigate the effects of atorvastatin (ATOR) on hepatic I/R injury and on serum levels of tumor necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), antithrombin III (ATIII) and intracellular adhesion molecule-1 (ICAM-1). Methods: Liver ischemia was induced in Wistar rats by clamping the HDL for 60 min, followed by either 60 or 180 min reperfusion. Rats received either vehicle or 10 mg/kg ATOR before hepatic I/R. Control group received sham surgery. Livers were examined for histological damage and serum AST, ALT, TNF-α, ET-1, ATIII and ICAM-1 concentrations were measured. Results: After I/R, AST and ALT were significantly elevated, ATIII levels were significantly depleted, both TNF-α and ICAM-1 levels increased and ET-1 was significantly elevated (at 180 min). ATOR pretreatment attenuated these alterations and diminished histological injury scores. Conclusions: Our results show that ATOR protects the liver from I/R injury. © 2014 IMSS.

AB - Background and Aims: Temporal occlusion of the hepatoduodenal ligament (HDL) is often used during liver surgeries in order to reduce blood loss, resulting in ischemia/reperfusion injury (I/R). The aim of the study was to investigate the effects of atorvastatin (ATOR) on hepatic I/R injury and on serum levels of tumor necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), antithrombin III (ATIII) and intracellular adhesion molecule-1 (ICAM-1). Methods: Liver ischemia was induced in Wistar rats by clamping the HDL for 60 min, followed by either 60 or 180 min reperfusion. Rats received either vehicle or 10 mg/kg ATOR before hepatic I/R. Control group received sham surgery. Livers were examined for histological damage and serum AST, ALT, TNF-α, ET-1, ATIII and ICAM-1 concentrations were measured. Results: After I/R, AST and ALT were significantly elevated, ATIII levels were significantly depleted, both TNF-α and ICAM-1 levels increased and ET-1 was significantly elevated (at 180 min). ATOR pretreatment attenuated these alterations and diminished histological injury scores. Conclusions: Our results show that ATOR protects the liver from I/R injury. © 2014 IMSS.

U2 - 10.1016/j.arcmed.2014.02.001

DO - 10.1016/j.arcmed.2014.02.001

M3 - Article

SP - 210

EP - 216

JO - Archives of Medical Research

JF - Archives of Medical Research

SN - 0188-4409

ER -

Cámara-Lemarroy CR, Guzmán-de la Garza FJ, Alarcón-Galván G, Cordero-Pérez P, Muñoz-Espinosa L, Torres-González L et al. Hepatic Ischemia/Reperfusion Injury Is Diminished by Atorvastatin in Wistar Rats. Archives of Medical Research. 2014 Jan 1;210-216. https://doi.org/10.1016/j.arcmed.2014.02.001