Helicobacter pylori drug resistance: therapy changes and challenges

Samantha Flores-Treviño, Soraya Mendoza-Olazarán, Paola Bocanegra-Ibarias, Héctor Jesús Maldonado-Garza, Elvira Garza-González

Research output: Contribution to journalReview articlepeer-review

71 Citations (Scopus)


INTRODUCTION: Helicobacter pylori is a Gram-negative bacterium that causes chronic gastritis, dyspepsia, peptic ulcers, and gastric cancer. Over half the world's population is infected with H. pylori, with higher prevalence in developing countries. Areas covered: In this review, current guidelines on H. pylori therapy, such as the Toronto consensus statement, the Maastricht V/Florence consensus report, and the American College of Gastroenterology guidelines, are compared. Also, we analyzed reports of antimicrobial resistance of H. pylori published in PubMed in the last years to determine current antimicrobial resistance worldwide. Expert commentary: Although H. pylori antimicrobial resistance varies by geographic area, its prevalence has been increasing over time, causing therapy failures and low eradication rates. To best optimize the management of H. pylori infection, H. pylori therapy should be based on patterns of local and individual antimicrobial resistance, if possible.

Original languageEnglish
Pages (from-to)819-827
Number of pages9
JournalExpert Review of Gastroenterology and Hepatology
Issue number8
Publication statusPublished - 3 Aug 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology


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