Handling of corneal decompensation with interweaving of colagen lamelas with LUV and riboflavin. Pilot study

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Abstract

Objective: To know the effect in the central corneal thickness of the corneal collagen crosslinking with ultraviolet A light and Riboflavin in patients with corneal edema secondary to seudophakic endothelial loss. Material and Methods: Prospective, longitudinal and experimental study, we included patients with corneal edema secondary to pseudophakic endothelial loss. After and before treatment with crosslinking we made study of ultrasound pachymetry, corneal hysteresis and intraocular pressure was measured. Follow up was made at first day, first week and first, second, third and sixth months after treatment. Results: Five patients, three men (60%) were included with a mean age 67.4 ± 5.7 years. At six months the central corneal thickness decrease from 790 ± 54.6 to 729 ± 116.5 (p= 0.04) μm and this difference was statistically significant, corneal transparency also improve from 0.4 ± 0.89 to 2 ± 1(p=0.008). All the other variables have no statistically significant changes. Conclusions: In this pilot study of five patients, the crosslinking treatment produce a decrease in the central corneal thickness and an improvement in the corneal transparency that continues at least for the first six months post treatment.
Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalRevista Mexicana de Oftalmologia
Publication statusPublished - 1 Jan 2012
Externally publishedYes

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Riboflavin
Corneal Edema
Corneal Pachymetry
Therapeutics
Ultraviolet Rays
Intraocular Pressure
Longitudinal Studies
Collagen

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

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title = "Handling of corneal decompensation with interweaving of colagen lamelas with LUV and riboflavin. Pilot study",
abstract = "Objective: To know the effect in the central corneal thickness of the corneal collagen crosslinking with ultraviolet A light and Riboflavin in patients with corneal edema secondary to seudophakic endothelial loss. Material and Methods: Prospective, longitudinal and experimental study, we included patients with corneal edema secondary to pseudophakic endothelial loss. After and before treatment with crosslinking we made study of ultrasound pachymetry, corneal hysteresis and intraocular pressure was measured. Follow up was made at first day, first week and first, second, third and sixth months after treatment. Results: Five patients, three men (60{\%}) were included with a mean age 67.4 ± 5.7 years. At six months the central corneal thickness decrease from 790 ± 54.6 to 729 ± 116.5 (p= 0.04) μm and this difference was statistically significant, corneal transparency also improve from 0.4 ± 0.89 to 2 ± 1(p=0.008). All the other variables have no statistically significant changes. Conclusions: In this pilot study of five patients, the crosslinking treatment produce a decrease in the central corneal thickness and an improvement in the corneal transparency that continues at least for the first six months post treatment.",
author = "Manuel Garza-Le{\'o}n",
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T1 - Handling of corneal decompensation with interweaving of colagen lamelas with LUV and riboflavin. Pilot study

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N2 - Objective: To know the effect in the central corneal thickness of the corneal collagen crosslinking with ultraviolet A light and Riboflavin in patients with corneal edema secondary to seudophakic endothelial loss. Material and Methods: Prospective, longitudinal and experimental study, we included patients with corneal edema secondary to pseudophakic endothelial loss. After and before treatment with crosslinking we made study of ultrasound pachymetry, corneal hysteresis and intraocular pressure was measured. Follow up was made at first day, first week and first, second, third and sixth months after treatment. Results: Five patients, three men (60%) were included with a mean age 67.4 ± 5.7 years. At six months the central corneal thickness decrease from 790 ± 54.6 to 729 ± 116.5 (p= 0.04) μm and this difference was statistically significant, corneal transparency also improve from 0.4 ± 0.89 to 2 ± 1(p=0.008). All the other variables have no statistically significant changes. Conclusions: In this pilot study of five patients, the crosslinking treatment produce a decrease in the central corneal thickness and an improvement in the corneal transparency that continues at least for the first six months post treatment.

AB - Objective: To know the effect in the central corneal thickness of the corneal collagen crosslinking with ultraviolet A light and Riboflavin in patients with corneal edema secondary to seudophakic endothelial loss. Material and Methods: Prospective, longitudinal and experimental study, we included patients with corneal edema secondary to pseudophakic endothelial loss. After and before treatment with crosslinking we made study of ultrasound pachymetry, corneal hysteresis and intraocular pressure was measured. Follow up was made at first day, first week and first, second, third and sixth months after treatment. Results: Five patients, three men (60%) were included with a mean age 67.4 ± 5.7 years. At six months the central corneal thickness decrease from 790 ± 54.6 to 729 ± 116.5 (p= 0.04) μm and this difference was statistically significant, corneal transparency also improve from 0.4 ± 0.89 to 2 ± 1(p=0.008). All the other variables have no statistically significant changes. Conclusions: In this pilot study of five patients, the crosslinking treatment produce a decrease in the central corneal thickness and an improvement in the corneal transparency that continues at least for the first six months post treatment.

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