Genotype and allele frequencies of polymorphic cytochromes P450 CYP1A2 and CYP2E1 in Mexicans

Ania Mendoza-Cantú, Fabiola Castorena-Torres, Mario Bermudez, Roberto Martínez-Hernández, Arturo Ortega, Juan E. Salinas, Arnulfo Albores

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

CYP1A2 and CYP2E1 are two of the main cytochrome P450 isoforms involved in the metabolism of commonly used drugs and xenobiotic compounds considered to be responsible for or possible participants in the development of several human diseases. Individual susceptibility to developing these pathologies relies, among other factors, on genetic polymorphism which depends on ethnic differences, as the frequency of mutant genotypes varies in different human populations. Thus the aim of this study was to investigate the frequency of CYP1A2 5′-flanking region and CYP2E1 Rsa I/Pst I polymorphisms in Mexicans by PCR-RFLP methods. The DNA of 159 subjects was analysed and mutant allele frequencies of 30% for CYP2E1 Rsa I/Pst I sites and 43% for CYP1A2 5′-flanking region were found. These frequencies are higher than those previously reported for other human populations. Copyright © 2003 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalCell Biochemistry and Function
DOIs
Publication statusPublished - 1 Jan 2004
Externally publishedYes

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Cytochrome P-450 CYP2E1
Cytochrome P-450 CYP1A2
Gene Frequency
Cytochrome P-450 Enzyme System
5' Flanking Region
Genotype
Polymorphism
Human Development
Pathology
Xenobiotics
Genetic Polymorphisms
Metabolism
Restriction Fragment Length Polymorphisms
Population
Protein Isoforms
Polymerase Chain Reaction
DNA
Pharmaceutical Preparations

Cite this

Mendoza-Cantú, A., Castorena-Torres, F., Bermudez, M., Martínez-Hernández, R., Ortega, A., Salinas, J. E., & Albores, A. (2004). Genotype and allele frequencies of polymorphic cytochromes P450 CYP1A2 and CYP2E1 in Mexicans. Cell Biochemistry and Function, 29-34. https://doi.org/10.1002/cbf.1049
Mendoza-Cantú, Ania ; Castorena-Torres, Fabiola ; Bermudez, Mario ; Martínez-Hernández, Roberto ; Ortega, Arturo ; Salinas, Juan E. ; Albores, Arnulfo. / Genotype and allele frequencies of polymorphic cytochromes P450 CYP1A2 and CYP2E1 in Mexicans. In: Cell Biochemistry and Function. 2004 ; pp. 29-34.
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Mendoza-Cantú, A, Castorena-Torres, F, Bermudez, M, Martínez-Hernández, R, Ortega, A, Salinas, JE & Albores, A 2004, 'Genotype and allele frequencies of polymorphic cytochromes P450 CYP1A2 and CYP2E1 in Mexicans', Cell Biochemistry and Function, pp. 29-34. https://doi.org/10.1002/cbf.1049

Genotype and allele frequencies of polymorphic cytochromes P450 CYP1A2 and CYP2E1 in Mexicans. / Mendoza-Cantú, Ania; Castorena-Torres, Fabiola; Bermudez, Mario; Martínez-Hernández, Roberto; Ortega, Arturo; Salinas, Juan E.; Albores, Arnulfo.

In: Cell Biochemistry and Function, 01.01.2004, p. 29-34.

Research output: Contribution to journalArticle

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AU - Mendoza-Cantú, Ania

AU - Castorena-Torres, Fabiola

AU - Bermudez, Mario

AU - Martínez-Hernández, Roberto

AU - Ortega, Arturo

AU - Salinas, Juan E.

AU - Albores, Arnulfo

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AB - CYP1A2 and CYP2E1 are two of the main cytochrome P450 isoforms involved in the metabolism of commonly used drugs and xenobiotic compounds considered to be responsible for or possible participants in the development of several human diseases. Individual susceptibility to developing these pathologies relies, among other factors, on genetic polymorphism which depends on ethnic differences, as the frequency of mutant genotypes varies in different human populations. Thus the aim of this study was to investigate the frequency of CYP1A2 5′-flanking region and CYP2E1 Rsa I/Pst I polymorphisms in Mexicans by PCR-RFLP methods. The DNA of 159 subjects was analysed and mutant allele frequencies of 30% for CYP2E1 Rsa I/Pst I sites and 43% for CYP1A2 5′-flanking region were found. These frequencies are higher than those previously reported for other human populations. Copyright © 2003 John Wiley & Sons, Ltd.

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Mendoza-Cantú A, Castorena-Torres F, Bermudez M, Martínez-Hernández R, Ortega A, Salinas JE et al. Genotype and allele frequencies of polymorphic cytochromes P450 CYP1A2 and CYP2E1 in Mexicans. Cell Biochemistry and Function. 2004 Jan 1;29-34. https://doi.org/10.1002/cbf.1049