Genetic risk factor in atopic dermatitis: "State of the art"

Julio César Salas-Alanís, Hector Eduardo López-Lozano, J. A. McGrath

Research output: Contribution to journalArticle

Abstract

Determining the precise genetic factors underlying complex trait diseases is difficult. Dissecting out susceptibility genes typically involves detailed mapping or population studies with analysis of large numbers of affected and unaffected individuals. To date, however, researchers have gained only limited insight into common multi-factorial diseases through such approaches. By contrast, identifying causative single genes in Mendelian disorders through genetic linkage, single nucleotide polymorphism or candidate gene screening has been very rewarding with identification of the genetic basis of over 300 autosomal recessive, dominant or X-linked disorders that have a skin phenotype. Recently, however, work on single gene disorders has also been able to provide specific clues to predisposing primary risk factors relevant to common complex diseases. This review article documents recent progress in understanding the genetic risk factors in the most common inflammatory dermatosis, atopic dermatitis, in which loss-of-function mutations in the gene encoding the skin barrier protein filaggrin are now known to be a major risk factor for both atopic dermatitis and atopic dermatitis associated with asthma.
Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalDermatologia Cosmetica, Medica y Quirurgica
Publication statusPublished - 1 Apr 2007
Externally publishedYes

Fingerprint

Atopic Dermatitis
Genes
Skin
Genetic Linkage
Skin Diseases
Single Nucleotide Polymorphism
Research Personnel
Phenotype
Mutation
Population
Proteins

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

Cite this

Salas-Alanís, J. C., López-Lozano, H. E., & McGrath, J. A. (2007). Genetic risk factor in atopic dermatitis: "State of the art". Dermatologia Cosmetica, Medica y Quirurgica, 101-104.
Salas-Alanís, Julio César ; López-Lozano, Hector Eduardo ; McGrath, J. A. / Genetic risk factor in atopic dermatitis: "State of the art". In: Dermatologia Cosmetica, Medica y Quirurgica. 2007 ; pp. 101-104.
@article{a58c57af2b7f4ddf8e65624f8a01d06b,
title = "Genetic risk factor in atopic dermatitis: {"}State of the art{"}",
abstract = "Determining the precise genetic factors underlying complex trait diseases is difficult. Dissecting out susceptibility genes typically involves detailed mapping or population studies with analysis of large numbers of affected and unaffected individuals. To date, however, researchers have gained only limited insight into common multi-factorial diseases through such approaches. By contrast, identifying causative single genes in Mendelian disorders through genetic linkage, single nucleotide polymorphism or candidate gene screening has been very rewarding with identification of the genetic basis of over 300 autosomal recessive, dominant or X-linked disorders that have a skin phenotype. Recently, however, work on single gene disorders has also been able to provide specific clues to predisposing primary risk factors relevant to common complex diseases. This review article documents recent progress in understanding the genetic risk factors in the most common inflammatory dermatosis, atopic dermatitis, in which loss-of-function mutations in the gene encoding the skin barrier protein filaggrin are now known to be a major risk factor for both atopic dermatitis and atopic dermatitis associated with asthma.",
author = "Salas-Alan{\'i}s, {Julio C{\'e}sar} and L{\'o}pez-Lozano, {Hector Eduardo} and McGrath, {J. A.}",
year = "2007",
month = "4",
day = "1",
language = "English",
pages = "101--104",
journal = "Dermatologia Cosmetica, Medica y Quirurgica",
issn = "1665-4390",
publisher = "Medipiel",

}

Salas-Alanís, JC, López-Lozano, HE & McGrath, JA 2007, 'Genetic risk factor in atopic dermatitis: "State of the art"', Dermatologia Cosmetica, Medica y Quirurgica, pp. 101-104.

Genetic risk factor in atopic dermatitis: "State of the art". / Salas-Alanís, Julio César; López-Lozano, Hector Eduardo; McGrath, J. A.

In: Dermatologia Cosmetica, Medica y Quirurgica, 01.04.2007, p. 101-104.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genetic risk factor in atopic dermatitis: "State of the art"

AU - Salas-Alanís, Julio César

AU - López-Lozano, Hector Eduardo

AU - McGrath, J. A.

PY - 2007/4/1

Y1 - 2007/4/1

N2 - Determining the precise genetic factors underlying complex trait diseases is difficult. Dissecting out susceptibility genes typically involves detailed mapping or population studies with analysis of large numbers of affected and unaffected individuals. To date, however, researchers have gained only limited insight into common multi-factorial diseases through such approaches. By contrast, identifying causative single genes in Mendelian disorders through genetic linkage, single nucleotide polymorphism or candidate gene screening has been very rewarding with identification of the genetic basis of over 300 autosomal recessive, dominant or X-linked disorders that have a skin phenotype. Recently, however, work on single gene disorders has also been able to provide specific clues to predisposing primary risk factors relevant to common complex diseases. This review article documents recent progress in understanding the genetic risk factors in the most common inflammatory dermatosis, atopic dermatitis, in which loss-of-function mutations in the gene encoding the skin barrier protein filaggrin are now known to be a major risk factor for both atopic dermatitis and atopic dermatitis associated with asthma.

AB - Determining the precise genetic factors underlying complex trait diseases is difficult. Dissecting out susceptibility genes typically involves detailed mapping or population studies with analysis of large numbers of affected and unaffected individuals. To date, however, researchers have gained only limited insight into common multi-factorial diseases through such approaches. By contrast, identifying causative single genes in Mendelian disorders through genetic linkage, single nucleotide polymorphism or candidate gene screening has been very rewarding with identification of the genetic basis of over 300 autosomal recessive, dominant or X-linked disorders that have a skin phenotype. Recently, however, work on single gene disorders has also been able to provide specific clues to predisposing primary risk factors relevant to common complex diseases. This review article documents recent progress in understanding the genetic risk factors in the most common inflammatory dermatosis, atopic dermatitis, in which loss-of-function mutations in the gene encoding the skin barrier protein filaggrin are now known to be a major risk factor for both atopic dermatitis and atopic dermatitis associated with asthma.

M3 - Article

SP - 101

EP - 104

JO - Dermatologia Cosmetica, Medica y Quirurgica

JF - Dermatologia Cosmetica, Medica y Quirurgica

SN - 1665-4390

ER -

Salas-Alanís JC, López-Lozano HE, McGrath JA. Genetic risk factor in atopic dermatitis: "State of the art". Dermatologia Cosmetica, Medica y Quirurgica. 2007 Apr 1;101-104.