Furanocoumarins from ruta chalepensis with amebicide activity

Aldo Fabio Bazaldúa-Rodríguez, Ramiro Quintanilla-Licea, María Julia Verde-Star, Magda Elizabeth Hernández-García, Javier Vargas-Villarreal, Jesús Norberto Garza-González

Research output: Contribution to journalArticlepeer-review

Abstract

Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Ru-taceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC50 values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.

Original languageEnglish
Article number3684
JournalMolecules
Volume26
Issue number12
DOIs
Publication statusPublished - 2 Jun 2021

Bibliographical note

Funding Information:
We acknowledge CONACYT (Mexico) for the doctoral fellowship awarded to Aldo Fabio Bazald?a Rodr?guez and the support given throughout the development of this research project. We also thank Benito David Mata-Cardenas and Javier Vargas-Villarreal for providing the protozoa E. histolytica used in this research. We thank H. Laatsch of the University of G?ttingen (Germany) for the spectroscopic measurements.

Funding Information:
Acknowledgments: We acknowledge CONACYT (Mexico) for the doctoral fellowship awarded to Aldo Fabio Bazaldúa Rodríguez and the support given throughout the development of this research project. We also thank Benito David Mata-Cardenas and Javier Vargas-Villarreal for providing the protozoa E. histolytica used in this research. We thank H. Laatsch of the University of Göttingen (Germany) for the spectroscopic measurements.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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