Furanocoumarins from ruta chalepensis with amebicide activity

Aldo Fabio Bazaldúa-Rodríguez; Ramiro Quintanilla-Licea; María Julia Verde-Star; Magda Elizabeth Hernández-García; Javier Vargas-Villarreal; Jesús Norberto Garza-González

doi:10.3390/molecules26123684

Furanocoumarins from ruta chalepensis with amebicide activity

Aldo Fabio Bazaldúa-Rodríguez, Ramiro Quintanilla-Licea^*, María Julia Verde-Star, Magda Elizabeth Hernández-García, Javier Vargas-Villarreal, Jesús Norberto Garza-González

^*Corresponding author for this work

Departamento Académico

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Ru-taceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC₅₀ values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.

Original language	English
Article number	3684
Journal	Molecules
Volume	26
Issue number	12
DOIs	https://doi.org/10.3390/molecules26123684
Publication status	Published - 2 Jun 2021

Bibliographical note

Funding Information:
Acknowledgments: We acknowledge CONACYT (Mexico) for the doctoral fellowship awarded to Aldo Fabio Bazaldúa Rodríguez and the support given throughout the development of this research project. We also thank Benito David Mata-Cardenas and Javier Vargas-Villarreal for providing the protozoa E. histolytica used in this research. We thank H. Laatsch of the University of Göttingen (Germany) for the spectroscopic measurements.

Funding Information:
We acknowledge CONACYT (Mexico) for the doctoral fellowship awarded to Aldo Fabio Bazaldúa Rodríguez and the support given throughout the development of this research project. We also thank Benito David Mata-Cardenas and Javier Vargas-Villarreal for providing the protozoa E. histolytica used in this research. We thank H. Laatsch of the University of Göttingen (Germany) for the spectroscopic measurements.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules26123684

Cite this

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title = "Furanocoumarins from ruta chalepensis with amebicide activity",

abstract = "Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Ru-taceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC50 values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.",

author = "Bazald{\'u}a-Rodr{\'i}guez, {Aldo Fabio} and Ramiro Quintanilla-Licea and Verde-Star, {Mar{\'i}a Julia} and Hern{\'a}ndez-Garc{\'i}a, {Magda Elizabeth} and Javier Vargas-Villarreal and Garza-Gonz{\'a}lez, {Jes{\'u}s Norberto}",

note = "Funding Information: Acknowledgments: We acknowledge CONACYT (Mexico) for the doctoral fellowship awarded to Aldo Fabio Bazald{\'u}a Rodr{\'i}guez and the support given throughout the development of this research project. We also thank Benito David Mata-Cardenas and Javier Vargas-Villarreal for providing the protozoa E. histolytica used in this research. We thank H. Laatsch of the University of G{\"o}ttingen (Germany) for the spectroscopic measurements. Funding Information: We acknowledge CONACYT (Mexico) for the doctoral fellowship awarded to Aldo Fabio Bazald{\'u}a Rodr{\'i}guez and the support given throughout the development of this research project. We also thank Benito David Mata-Cardenas and Javier Vargas-Villarreal for providing the protozoa E. histolytica used in this research. We thank H. Laatsch of the University of G{\"o}ttingen (Germany) for the spectroscopic measurements. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Hernández-García, Magda Elizabeth

AU - Vargas-Villarreal, Javier

AU - Garza-González, Jesús Norberto

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N2 - Entamoeba histolytica (protozoan; family Endomoebidae) is the cause of amoebiasis, a disease related to high morbidity and mortality. Nowadays, this illness is considered a significant public health issue in developing countries. In addition, parasite resistance to conventional medicinal treatment has increased in recent years. Traditional medicine around the world represents a valuable source of alternative treatment for many parasite diseases. In a previous paper, we communicated about the antiprotozoal activity in vitro of the methanolic (MeOH) extract of Ruta chalepensis (Ru-taceae) against E. histolytica. The plant is extensively employed in Mexican traditional medicine. The following workup of the MeOH extract of R. chalepensis afforded the furocoumarins rutamarin (1) and chalepin (2), which showed high antiprotozoal activity on Entamoeba histolytica trophozoites employing in vitro tests (IC50 values of 6.52 and 28.95 µg/mL, respectively). Therefore, we offer a full scientific report about the bioguided isolation and the amebicide activity of chalepin and rutamarin.

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Furanocoumarins from ruta chalepensis with amebicide activity

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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