Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq

Lizeth Martinez-Jacobo, Claudia I. Ancer-Arellano, Rocio Ortiz-Lopez, Mauricio Salinas-Santander, Cesar Daniel Villarreal-Villarreal, Jesus Ancer-Rodriguez, Bianka Camacho-Zamora, Viviana Zomosa-Signoret, Carlos E. Medina-De La Garza, Jorge Ocampo-Candiani, Augusto Rojas-Martinez

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    © 2018 S. Karger AG, Basel. Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder.
    Original languageEnglish
    Pages (from-to)268-273
    Number of pages6
    JournalSkin Appendage Disorders
    Volume4
    Issue number4
    DOIs
    Publication statusPublished - 1 Oct 2018

    Bibliographical note

    Publisher Copyright:
    © 2018 S. Karger AG, Basel.

    All Science Journal Classification (ASJC) codes

    • Dermatology

    Fingerprint

    Dive into the research topics of 'Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq'. Together they form a unique fingerprint.

    Cite this