Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq

Lizeth Martinez-Jacobo, Claudia I. Ancer-Arellano, Rocio Ortiz-Lopez, Mauricio Salinas-Santander, Cesar Daniel Villarreal-Villarreal, Jesus Ancer-Rodriguez, Bianka Camacho-Zamora, Viviana Zomosa-Signoret, Carlos E. Medina-De La Garza, Jorge Ocampo-Candiani, Augusto Rojas-Martinez

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

© 2018 S. Karger AG, Basel. Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder.
Original languageEnglish
Pages (from-to)268-273
Number of pages6
JournalSkin Appendage Disorders
Volume4
Issue number4
DOIs
Publication statusPublished - 1 Oct 2018

All Science Journal Classification (ASJC) codes

  • Dermatology

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