TY - JOUR
T1 - Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq
AU - Martinez-Jacobo, Lizeth
AU - Ancer-Arellano, Claudia I.
AU - Ortiz-Lopez, Rocio
AU - Salinas-Santander, Mauricio
AU - Villarreal-Villarreal, Cesar Daniel
AU - Ancer-Rodriguez, Jesus
AU - Camacho-Zamora, Bianka
AU - Zomosa-Signoret, Viviana
AU - Medina-De La Garza, Carlos E.
AU - Ocampo-Candiani, Jorge
AU - Rojas-Martinez, Augusto
N1 - Publisher Copyright:
© 2018 S. Karger AG, Basel.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - © 2018 S. Karger AG, Basel. Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder.
AB - © 2018 S. Karger AG, Basel. Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder.
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UR - https://www.mendeley.com/catalogue/cd334b1c-41eb-3f1f-a6e6-eff32aee8cc8/
U2 - 10.1159/000484530
DO - 10.1159/000484530
M3 - Article
AN - SCOPUS:85055373183
SN - 2296-9195
VL - 4
SP - 268
EP - 273
JO - Skin Appendage Disorders
JF - Skin Appendage Disorders
IS - 4
ER -