Evaluation of DNA damage in obese children using the chromatin dispersion test

Martha I. Dávila-Rodríguez; Francisco González-Salazar; Manuel López-Cabanillas; Ricardo M. Cerda-Flores; Elva I. Cortés-Gutiérrez

doi:10.1080/10520295.2023.2210848

Evaluation of DNA damage in obese children using the chromatin dispersion test

Martha I. Dávila-Rodríguez, Francisco González-Salazar, Manuel López-Cabanillas, Ricardo M. Cerda-Flores, Elva I. Cortés-Gutiérrez^*

^*Corresponding author for this work

Departamento Académico

Research output: Contribution to journal › Article › peer-review

Abstract

Childhood obesity predicts adult obesity and may increase the lifetime risk of adverse health outcomes. Obesity is characterized by oxidative stress that can induce DNA damage; however, studies of childhood and adolescent obesity are scarce. We investigated DNA damage due to obesity in Mexican children using the chromatin dispersion test (CDT). We evaluated DNA damage to peripheral lymphocytes of 32 children grouped according to body mass index as normal weight (controls), overweight and obese groups using guidelines from the Centers for Disease Control (CDC). We found that the greatest DNA damage occurred in cells of obese children compared to normal weight and overweight children. Our findings support preventive action to obviate adverse health outcomes due to obesity.

Original language	English
Pages (from-to)	396-400
Number of pages	5
Journal	Biotechnic and Histochemistry
Volume	98
Issue number	6
DOIs	https://doi.org/10.1080/10520295.2023.2210848
Publication status	Published - 2023

Bibliographical note

Funding Information:
The authors are grateful to the Family Medicine Unit No. 26, Instituto Mexicano del Seguro Social, Monterrey, Mexico, for use of their facilities for sampling and interviewing study participants. We thank San Juana Guardado Limón for her technical assistance.

Publisher Copyright:
© 2023 The Biological Stain Commission.

All Science Journal Classification (ASJC) codes

Histology
Medical Laboratory Technology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10520295.2023.2210848

Cite this

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title = "Evaluation of DNA damage in obese children using the chromatin dispersion test",

abstract = "Childhood obesity predicts adult obesity and may increase the lifetime risk of adverse health outcomes. Obesity is characterized by oxidative stress that can induce DNA damage; however, studies of childhood and adolescent obesity are scarce. We investigated DNA damage due to obesity in Mexican children using the chromatin dispersion test (CDT). We evaluated DNA damage to peripheral lymphocytes of 32 children grouped according to body mass index as normal weight (controls), overweight and obese groups using guidelines from the Centers for Disease Control (CDC). We found that the greatest DNA damage occurred in cells of obese children compared to normal weight and overweight children. Our findings support preventive action to obviate adverse health outcomes due to obesity.",

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note = "Funding Information: The authors are grateful to the Family Medicine Unit No. 26, Instituto Mexicano del Seguro Social, Monterrey, Mexico, for use of their facilities for sampling and interviewing study participants. We thank San Juana Guardado Lim{\'o}n for her technical assistance. Publisher Copyright: {\textcopyright} 2023 The Biological Stain Commission.",

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doi = "10.1080/10520295.2023.2210848",

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AU - Dávila-Rodríguez, Martha I.

AU - González-Salazar, Francisco

AU - López-Cabanillas, Manuel

AU - Cerda-Flores, Ricardo M.

AU - Cortés-Gutiérrez, Elva I.

N1 - Funding Information: The authors are grateful to the Family Medicine Unit No. 26, Instituto Mexicano del Seguro Social, Monterrey, Mexico, for use of their facilities for sampling and interviewing study participants. We thank San Juana Guardado Limón for her technical assistance. Publisher Copyright: © 2023 The Biological Stain Commission.

PY - 2023

Y1 - 2023

N2 - Childhood obesity predicts adult obesity and may increase the lifetime risk of adverse health outcomes. Obesity is characterized by oxidative stress that can induce DNA damage; however, studies of childhood and adolescent obesity are scarce. We investigated DNA damage due to obesity in Mexican children using the chromatin dispersion test (CDT). We evaluated DNA damage to peripheral lymphocytes of 32 children grouped according to body mass index as normal weight (controls), overweight and obese groups using guidelines from the Centers for Disease Control (CDC). We found that the greatest DNA damage occurred in cells of obese children compared to normal weight and overweight children. Our findings support preventive action to obviate adverse health outcomes due to obesity.

AB - Childhood obesity predicts adult obesity and may increase the lifetime risk of adverse health outcomes. Obesity is characterized by oxidative stress that can induce DNA damage; however, studies of childhood and adolescent obesity are scarce. We investigated DNA damage due to obesity in Mexican children using the chromatin dispersion test (CDT). We evaluated DNA damage to peripheral lymphocytes of 32 children grouped according to body mass index as normal weight (controls), overweight and obese groups using guidelines from the Centers for Disease Control (CDC). We found that the greatest DNA damage occurred in cells of obese children compared to normal weight and overweight children. Our findings support preventive action to obviate adverse health outcomes due to obesity.

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Evaluation of DNA damage in obese children using the chromatin dispersion test

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

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