Evaluation of DNA damage in obese children using the chromatin dispersion test

Martha I. Dávila-Rodríguez, Francisco González-Salazar, Manuel López-Cabanillas, Ricardo M. Cerda-Flores, Elva I. Cortés-Gutiérrez*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Childhood obesity predicts adult obesity and may increase the lifetime risk of adverse health outcomes. Obesity is characterized by oxidative stress that can induce DNA damage; however, studies of childhood and adolescent obesity are scarce. We investigated DNA damage due to obesity in Mexican children using the chromatin dispersion test (CDT). We evaluated DNA damage to peripheral lymphocytes of 32 children grouped according to body mass index as normal weight (controls), overweight and obese groups using guidelines from the Centers for Disease Control (CDC). We found that the greatest DNA damage occurred in cells of obese children compared to normal weight and overweight children. Our findings support preventive action to obviate adverse health outcomes due to obesity.

Original languageEnglish
Pages (from-to)396-400
Number of pages5
JournalBiotechnic and Histochemistry
Issue number6
Publication statusPublished - 2023

Bibliographical note

Funding Information:
The authors are grateful to the Family Medicine Unit No. 26, Instituto Mexicano del Seguro Social, Monterrey, Mexico, for use of their facilities for sampling and interviewing study participants. We thank San Juana Guardado Limón for her technical assistance.

Publisher Copyright:
© 2023 The Biological Stain Commission.

All Science Journal Classification (ASJC) codes

  • Histology
  • Medical Laboratory Technology


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