Effect of bismuth lipophilic nanoparticles (BisBAL NPs) on Trichomonas vaginalis growth

Osvelia E. Rodríguez-Luis, Rene Hernández-Delgadillo, Nayely Pineda-Aguilar, Javier Vargas-Villarreal, Francisco González-Salazar, Jesús Norberto Garza-González, Magda Elizabeth Hernández-García, Shankararaman Chellam, Claudio Cabral-Romero

Research output: Contribution to journalArticle

Abstract

Copyright © 2017 American Scientific Publishers All rights reserved. The most common treatment to trichomoniasis is the use of metronidazole; however several studies have shown that at least 5% of clinical cases of trichomoniasis are caused by parasites resistant to the drug. Lipophilic bismuth nanoparticles (BisBAL NPs) have an important antimicrobial activity; however the influence of BisBAL NPs on human parasites has not been studied. The objective of this study was to determine the effect of bismuth lipophilic nanoparticles on Trichomonas vaginalis growth. The bismuth nanoparticles synthesized by colloidal method are composed of ≥100 nm crystallites and have a spherical structure, agglomerating into clusters of small nanoparticles. Based on cell viability assays and fluorescence microscopy, Trichomonas vaginalis growth was inhibited with the addition of 62.5-125 μg/mL of BisBAL NPs. Fluorescence micrographs showed live T. vaginalis in absence of any drug treatment and after exposed for 24 h. with 500 μg/mL of BisBAL NPs or 1.3 μg/mL metronidazole a dark background was observed with cellular debris stain. In summary, here we present evidence for first time of the antiparasitic activity of lipophilic bismuth nanoparticles being as effective as metronidazole to interfere with T. vaginalis growth. BisBAL nanoparticles could be an interesting alternative to treat and prevent parasitic infections.
Original languageEnglish
Pages (from-to)4618-4622
Number of pages5
JournalJournal of Nanoscience and Nanotechnology
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Fingerprint

Trichomonas vaginalis
Bismuth
Nanoparticles
Metronidazole
Growth
Parasites
Antiparasitic Agents
Parasitic Diseases
Fluorescence Microscopy
Pharmaceutical Preparations
Cell Survival
Coloring Agents
Fluorescence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Rodríguez-Luis, O. E., Hernández-Delgadillo, R., Pineda-Aguilar, N., Vargas-Villarreal, J., González-Salazar, F., Garza-González, J. N., ... Cabral-Romero, C. (2017). Effect of bismuth lipophilic nanoparticles (BisBAL NPs) on Trichomonas vaginalis growth. Journal of Nanoscience and Nanotechnology, 4618-4622. https://doi.org/10.1166/jnn.2017.13743
Rodríguez-Luis, Osvelia E. ; Hernández-Delgadillo, Rene ; Pineda-Aguilar, Nayely ; Vargas-Villarreal, Javier ; González-Salazar, Francisco ; Garza-González, Jesús Norberto ; Hernández-García, Magda Elizabeth ; Chellam, Shankararaman ; Cabral-Romero, Claudio. / Effect of bismuth lipophilic nanoparticles (BisBAL NPs) on Trichomonas vaginalis growth. In: Journal of Nanoscience and Nanotechnology. 2017 ; pp. 4618-4622.
@article{b0c2d8b8392e4011acd67c141bf971f8,
title = "Effect of bismuth lipophilic nanoparticles (BisBAL NPs) on Trichomonas vaginalis growth",
abstract = "Copyright {\circledC} 2017 American Scientific Publishers All rights reserved. The most common treatment to trichomoniasis is the use of metronidazole; however several studies have shown that at least 5{\%} of clinical cases of trichomoniasis are caused by parasites resistant to the drug. Lipophilic bismuth nanoparticles (BisBAL NPs) have an important antimicrobial activity; however the influence of BisBAL NPs on human parasites has not been studied. The objective of this study was to determine the effect of bismuth lipophilic nanoparticles on Trichomonas vaginalis growth. The bismuth nanoparticles synthesized by colloidal method are composed of ≥100 nm crystallites and have a spherical structure, agglomerating into clusters of small nanoparticles. Based on cell viability assays and fluorescence microscopy, Trichomonas vaginalis growth was inhibited with the addition of 62.5-125 μg/mL of BisBAL NPs. Fluorescence micrographs showed live T. vaginalis in absence of any drug treatment and after exposed for 24 h. with 500 μg/mL of BisBAL NPs or 1.3 μg/mL metronidazole a dark background was observed with cellular debris stain. In summary, here we present evidence for first time of the antiparasitic activity of lipophilic bismuth nanoparticles being as effective as metronidazole to interfere with T. vaginalis growth. BisBAL nanoparticles could be an interesting alternative to treat and prevent parasitic infections.",
author = "Rodr{\'i}guez-Luis, {Osvelia E.} and Rene Hern{\'a}ndez-Delgadillo and Nayely Pineda-Aguilar and Javier Vargas-Villarreal and Francisco Gonz{\'a}lez-Salazar and Garza-Gonz{\'a}lez, {Jes{\'u}s Norberto} and Hern{\'a}ndez-Garc{\'i}a, {Magda Elizabeth} and Shankararaman Chellam and Claudio Cabral-Romero",
year = "2017",
month = "1",
day = "1",
doi = "10.1166/jnn.2017.13743",
language = "English",
pages = "4618--4622",
journal = "Journal of Nanoscience and Nanotechnology",
issn = "1533-4880",
publisher = "American Scientific Publishers",

}

Rodríguez-Luis, OE, Hernández-Delgadillo, R, Pineda-Aguilar, N, Vargas-Villarreal, J, González-Salazar, F, Garza-González, JN, Hernández-García, ME, Chellam, S & Cabral-Romero, C 2017, 'Effect of bismuth lipophilic nanoparticles (BisBAL NPs) on Trichomonas vaginalis growth', Journal of Nanoscience and Nanotechnology, pp. 4618-4622. https://doi.org/10.1166/jnn.2017.13743

Effect of bismuth lipophilic nanoparticles (BisBAL NPs) on Trichomonas vaginalis growth. / Rodríguez-Luis, Osvelia E.; Hernández-Delgadillo, Rene; Pineda-Aguilar, Nayely; Vargas-Villarreal, Javier; González-Salazar, Francisco; Garza-González, Jesús Norberto; Hernández-García, Magda Elizabeth; Chellam, Shankararaman; Cabral-Romero, Claudio.

In: Journal of Nanoscience and Nanotechnology, 01.01.2017, p. 4618-4622.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of bismuth lipophilic nanoparticles (BisBAL NPs) on Trichomonas vaginalis growth

AU - Rodríguez-Luis, Osvelia E.

AU - Hernández-Delgadillo, Rene

AU - Pineda-Aguilar, Nayely

AU - Vargas-Villarreal, Javier

AU - González-Salazar, Francisco

AU - Garza-González, Jesús Norberto

AU - Hernández-García, Magda Elizabeth

AU - Chellam, Shankararaman

AU - Cabral-Romero, Claudio

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Copyright © 2017 American Scientific Publishers All rights reserved. The most common treatment to trichomoniasis is the use of metronidazole; however several studies have shown that at least 5% of clinical cases of trichomoniasis are caused by parasites resistant to the drug. Lipophilic bismuth nanoparticles (BisBAL NPs) have an important antimicrobial activity; however the influence of BisBAL NPs on human parasites has not been studied. The objective of this study was to determine the effect of bismuth lipophilic nanoparticles on Trichomonas vaginalis growth. The bismuth nanoparticles synthesized by colloidal method are composed of ≥100 nm crystallites and have a spherical structure, agglomerating into clusters of small nanoparticles. Based on cell viability assays and fluorescence microscopy, Trichomonas vaginalis growth was inhibited with the addition of 62.5-125 μg/mL of BisBAL NPs. Fluorescence micrographs showed live T. vaginalis in absence of any drug treatment and after exposed for 24 h. with 500 μg/mL of BisBAL NPs or 1.3 μg/mL metronidazole a dark background was observed with cellular debris stain. In summary, here we present evidence for first time of the antiparasitic activity of lipophilic bismuth nanoparticles being as effective as metronidazole to interfere with T. vaginalis growth. BisBAL nanoparticles could be an interesting alternative to treat and prevent parasitic infections.

AB - Copyright © 2017 American Scientific Publishers All rights reserved. The most common treatment to trichomoniasis is the use of metronidazole; however several studies have shown that at least 5% of clinical cases of trichomoniasis are caused by parasites resistant to the drug. Lipophilic bismuth nanoparticles (BisBAL NPs) have an important antimicrobial activity; however the influence of BisBAL NPs on human parasites has not been studied. The objective of this study was to determine the effect of bismuth lipophilic nanoparticles on Trichomonas vaginalis growth. The bismuth nanoparticles synthesized by colloidal method are composed of ≥100 nm crystallites and have a spherical structure, agglomerating into clusters of small nanoparticles. Based on cell viability assays and fluorescence microscopy, Trichomonas vaginalis growth was inhibited with the addition of 62.5-125 μg/mL of BisBAL NPs. Fluorescence micrographs showed live T. vaginalis in absence of any drug treatment and after exposed for 24 h. with 500 μg/mL of BisBAL NPs or 1.3 μg/mL metronidazole a dark background was observed with cellular debris stain. In summary, here we present evidence for first time of the antiparasitic activity of lipophilic bismuth nanoparticles being as effective as metronidazole to interfere with T. vaginalis growth. BisBAL nanoparticles could be an interesting alternative to treat and prevent parasitic infections.

U2 - 10.1166/jnn.2017.13743

DO - 10.1166/jnn.2017.13743

M3 - Article

SP - 4618

EP - 4622

JO - Journal of Nanoscience and Nanotechnology

JF - Journal of Nanoscience and Nanotechnology

SN - 1533-4880

ER -

Rodríguez-Luis OE, Hernández-Delgadillo R, Pineda-Aguilar N, Vargas-Villarreal J, González-Salazar F, Garza-González JN et al. Effect of bismuth lipophilic nanoparticles (BisBAL NPs) on Trichomonas vaginalis growth. Journal of Nanoscience and Nanotechnology. 2017 Jan 1;4618-4622. https://doi.org/10.1166/jnn.2017.13743