Drug resistance and molecular epidemiology of Mycobacterium tuberculosis in Mexico: a systematic review

Samantha Flores-Treviño, Soraya Mendoza-Olazarán, Elvira Garza-González

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

OBJECTIVE: To compare drug resistance (DR) rates and genetic diversity of Mycobacterium tuberculosis strains from different states of Mexico.

MATERIALS AND METHODS: A systematic review of English and Spanish-language articles using MEDLINE and Google Scholar. Search terms included Mycobacterium tuberculosis, Mexico, resistance, mutation and epidemiology.

RESULTS: Fifteen studies for phenotypic DR rates (n=2 694), twelve studies for genotypic DR (n=748) and eleven studies for genetic diversity (n=2 044) met our inclusion criteria. Mean DR and multidrug resistance (MDR) rates were 37.5% and 20.6%, respectively. The most frequent mutations were rpoB531 (53.1%), katG315 (50.6%), embB306 (32.1%), rpsL43 (14.6%) and pncA359 (16.7%) in DR strains. Novel mutations were found. Predominant shared types were SIT53 (T1, n=188, 3.9%), SIT119 (X1, n=125, 6.9%), SIT19 (EAI2-Manila, n=80, 6.3%) and SIT42 (LAM9, n=77, 3.0%). SIT1 Beijing genotype has been reported in six states from Mexico.

CONCLUSIONS: DR and MDR rates continue to increase. Genetic diversity of M. tuberculosis strains in Mexico is high. Reports of Beijing strains are increasing.

Original languageEnglish
Pages (from-to)63-77
Number of pages15
JournalSalud Publica de Mexico
Volume56
Issue number1
Publication statusPublished - 11 Jun 2014
Externally publishedYes

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Molecular Epidemiology
Mexico
Mycobacterium tuberculosis
Drug Resistance
Multiple Drug Resistance
Mutation
MEDLINE
Epidemiology
Language
Genotype

Cite this

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title = "Drug resistance and molecular epidemiology of Mycobacterium tuberculosis in Mexico: a systematic review",
abstract = "OBJECTIVE: To compare drug resistance (DR) rates and genetic diversity of Mycobacterium tuberculosis strains from different states of Mexico.MATERIALS AND METHODS: A systematic review of English and Spanish-language articles using MEDLINE and Google Scholar. Search terms included Mycobacterium tuberculosis, Mexico, resistance, mutation and epidemiology.RESULTS: Fifteen studies for phenotypic DR rates (n=2 694), twelve studies for genotypic DR (n=748) and eleven studies for genetic diversity (n=2 044) met our inclusion criteria. Mean DR and multidrug resistance (MDR) rates were 37.5{\%} and 20.6{\%}, respectively. The most frequent mutations were rpoB531 (53.1{\%}), katG315 (50.6{\%}), embB306 (32.1{\%}), rpsL43 (14.6{\%}) and pncA359 (16.7{\%}) in DR strains. Novel mutations were found. Predominant shared types were SIT53 (T1, n=188, 3.9{\%}), SIT119 (X1, n=125, 6.9{\%}), SIT19 (EAI2-Manila, n=80, 6.3{\%}) and SIT42 (LAM9, n=77, 3.0{\%}). SIT1 Beijing genotype has been reported in six states from Mexico.CONCLUSIONS: DR and MDR rates continue to increase. Genetic diversity of M. tuberculosis strains in Mexico is high. Reports of Beijing strains are increasing.",
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Drug resistance and molecular epidemiology of Mycobacterium tuberculosis in Mexico : a systematic review. / Flores-Treviño, Samantha; Mendoza-Olazarán, Soraya; Garza-González, Elvira.

In: Salud Publica de Mexico, Vol. 56, No. 1, 11.06.2014, p. 63-77.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Drug resistance and molecular epidemiology of Mycobacterium tuberculosis in Mexico

T2 - a systematic review

AU - Flores-Treviño, Samantha

AU - Mendoza-Olazarán, Soraya

AU - Garza-González, Elvira

PY - 2014/6/11

Y1 - 2014/6/11

N2 - OBJECTIVE: To compare drug resistance (DR) rates and genetic diversity of Mycobacterium tuberculosis strains from different states of Mexico.MATERIALS AND METHODS: A systematic review of English and Spanish-language articles using MEDLINE and Google Scholar. Search terms included Mycobacterium tuberculosis, Mexico, resistance, mutation and epidemiology.RESULTS: Fifteen studies for phenotypic DR rates (n=2 694), twelve studies for genotypic DR (n=748) and eleven studies for genetic diversity (n=2 044) met our inclusion criteria. Mean DR and multidrug resistance (MDR) rates were 37.5% and 20.6%, respectively. The most frequent mutations were rpoB531 (53.1%), katG315 (50.6%), embB306 (32.1%), rpsL43 (14.6%) and pncA359 (16.7%) in DR strains. Novel mutations were found. Predominant shared types were SIT53 (T1, n=188, 3.9%), SIT119 (X1, n=125, 6.9%), SIT19 (EAI2-Manila, n=80, 6.3%) and SIT42 (LAM9, n=77, 3.0%). SIT1 Beijing genotype has been reported in six states from Mexico.CONCLUSIONS: DR and MDR rates continue to increase. Genetic diversity of M. tuberculosis strains in Mexico is high. Reports of Beijing strains are increasing.

AB - OBJECTIVE: To compare drug resistance (DR) rates and genetic diversity of Mycobacterium tuberculosis strains from different states of Mexico.MATERIALS AND METHODS: A systematic review of English and Spanish-language articles using MEDLINE and Google Scholar. Search terms included Mycobacterium tuberculosis, Mexico, resistance, mutation and epidemiology.RESULTS: Fifteen studies for phenotypic DR rates (n=2 694), twelve studies for genotypic DR (n=748) and eleven studies for genetic diversity (n=2 044) met our inclusion criteria. Mean DR and multidrug resistance (MDR) rates were 37.5% and 20.6%, respectively. The most frequent mutations were rpoB531 (53.1%), katG315 (50.6%), embB306 (32.1%), rpsL43 (14.6%) and pncA359 (16.7%) in DR strains. Novel mutations were found. Predominant shared types were SIT53 (T1, n=188, 3.9%), SIT119 (X1, n=125, 6.9%), SIT19 (EAI2-Manila, n=80, 6.3%) and SIT42 (LAM9, n=77, 3.0%). SIT1 Beijing genotype has been reported in six states from Mexico.CONCLUSIONS: DR and MDR rates continue to increase. Genetic diversity of M. tuberculosis strains in Mexico is high. Reports of Beijing strains are increasing.

M3 - Review article

C2 - 24912522

VL - 56

SP - 63

EP - 77

JO - Salud Publica de Mexico

JF - Salud Publica de Mexico

SN - 0036-3634

IS - 1

ER -