Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers

Antonio Martinez-Torteya; Alejandro I. Trejo-Castro; José M. Celaya-Padilla; Jose G. Tamez-Peña

doi:10.1109/bibe.2019.00043

Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers

Antonio Martinez-Torteya, Alejandro I. Trejo-Castro, José M. Celaya-Padilla, Jose G. Tamez-Peña

Departamento de Ingeniería

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.

Original language	English
Title of host publication	Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	199-203
Number of pages	5
ISBN (Electronic)	9781728146171
ISBN (Print)	9781728146171
DOIs	https://doi.org/10.1109/bibe.2019.00043
Publication status	Published - Oct 2019

Publication series

Name	Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019

Bibliographical note

Funding Information:
This work was partially supported by the Consejo Nacional de Ciencia y Tecnologia (CONACYT) and by Universidad de Monterrey through the FFI Grant

Funding Information:
ACKNOWLEDGMENT This work was partially supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT) and by Universidad de Monterrey through the FFI Grant.

Publisher Copyright:
© 2019 IEEE.

All Science Journal Classification (ASJC) codes

Information Systems
Biomedical Engineering
Health Informatics

Access to Document

10.1109/bibe.2019.00043

Cite this

Martinez-Torteya, A., Trejo-Castro, A. I., Celaya-Padilla, J. M., & Tamez-Peña, J. G. (2019). Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. In Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019 (pp. 199-203). [8941924] (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/bibe.2019.00043

Martinez-Torteya, Antonio ; Trejo-Castro, Alejandro I. ; Celaya-Padilla, José M. et al. / Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019. Institute of Electrical and Electronics Engineers (IEEE), 2019. pp. 199-203 (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019).

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abstract = "An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.",

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note = "Funding Information: This work was partially supported by the Consejo Nacional de Ciencia y Tecnologia (CONACYT) and by Universidad de Monterrey through the FFI Grant Funding Information: ACKNOWLEDGMENT This work was partially supported by the Consejo Nacional de Ciencia y Tecnolog{\'i}a (CONACYT) and by Universidad de Monterrey through the FFI Grant. Publisher Copyright: {\textcopyright} 2019 IEEE.",

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Martinez-Torteya, A, Trejo-Castro, AI, Celaya-Padilla, JM & Tamez-Peña, JG 2019, Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. in Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019., 8941924, Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019, Institute of Electrical and Electronics Engineers (IEEE), pp. 199-203. https://doi.org/10.1109/bibe.2019.00043

Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. / Martinez-Torteya, Antonio; Trejo-Castro, Alejandro I.; Celaya-Padilla, José M. et al.

Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019. Institute of Electrical and Electronics Engineers (IEEE), 2019. p. 199-203 8941924 (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Tamez-Peña, Jose G.

N1 - Funding Information: This work was partially supported by the Consejo Nacional de Ciencia y Tecnologia (CONACYT) and by Universidad de Monterrey through the FFI Grant Funding Information: ACKNOWLEDGMENT This work was partially supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT) and by Universidad de Monterrey through the FFI Grant. Publisher Copyright: © 2019 IEEE.

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N2 - An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.

AB - An early diagnosis of Alzheimer's disease (AD) is important for both support and therapeutic planning. Predicting who will progress from mild cognitive impairment (MCI) to AD would yield the same clinical benefits. However, it has been shown that the MCI to AD progression varies depending on certain demographic characteristics. AD is highly associated with the apolipoprotein E type 4 allele expressing the protein isoform APOE4. This study aimed at identifying features associated with the MCI to AD progression whose temporal evolution significantly differs between APOE4 carriers and non-carriers. Longitudinal information from 336 subjects (64.58% carriers) who progressed from MCI to AD was gathered, including laboratory assays, information from MRI and PET analyses, and neuropsychological tests. Longitudinal models identified 11 features with significant differences in their behavior between carriers and non-carriers, demonstrating that the way in which carriers and non-carriers progress from MCI to AD is significantly different.

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BT - Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019

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Martinez-Torteya A, Trejo-Castro AI, Celaya-Padilla JM, Tamez-Peña JG. Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers. In Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019. Institute of Electrical and Electronics Engineers (IEEE). 2019. p. 199-203. 8941924. (Proceedings - 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering, BIBE 2019). doi: 10.1109/bibe.2019.00043

Differences in the Progression from Mild Cognitive Impairment to Alzheimer's Disease between APOE4 Carriers and Non-Carriers

Abstract

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Bibliographical note

All Science Journal Classification (ASJC) codes

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