Cytokines: Monitors of disease severity for the clinic

Irene Meester, Juan Manuel Solis-Soto

Research output: Contribution to journalLiterature review

2 Citations (Scopus)

Abstract

Background: Cytokines communicate between the cells of the immune system and its targets to maintain homeostasis after injury or pathogenic events. They are involved in almost any pathological situation imaginable. Objective: To verify the importance of cytokines as biomarkers in current preclinical (aetiopathogenic, development of new therapies) and clinical studies (diagnosis, disease severity, prognosis and response to therapy). Method/results: A Medline search with the query 'cytokine' AND 'biomarker' AND a variable for a variety of biomedical fields, followed by deeper-level searches, demonstrated the immense popularity of cytokines as biomarkers in almost any biomedical field. Conclusion: As cytokines are not disease-specific they do not serve as single diagnostic biomarkers. The strength of the cytokines resides in monitoring disease severity, prognosis and response to treatment. © 2009 Informa UK Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)143-155
Number of pages13
JournalExpert Opinion on Medical Diagnostics
DOIs
Publication statusPublished - 1 Mar 2009
Externally publishedYes

Fingerprint

Biomarkers
Cytokines
Immune system
Immune System
Homeostasis
Monitoring
Wounds and Injuries
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Biomedical Engineering
  • Biochemistry, medical

Cite this

@article{1a386c4c962d4f679742f2a419c533f3,
title = "Cytokines: Monitors of disease severity for the clinic",
abstract = "Background: Cytokines communicate between the cells of the immune system and its targets to maintain homeostasis after injury or pathogenic events. They are involved in almost any pathological situation imaginable. Objective: To verify the importance of cytokines as biomarkers in current preclinical (aetiopathogenic, development of new therapies) and clinical studies (diagnosis, disease severity, prognosis and response to therapy). Method/results: A Medline search with the query 'cytokine' AND 'biomarker' AND a variable for a variety of biomedical fields, followed by deeper-level searches, demonstrated the immense popularity of cytokines as biomarkers in almost any biomedical field. Conclusion: As cytokines are not disease-specific they do not serve as single diagnostic biomarkers. The strength of the cytokines resides in monitoring disease severity, prognosis and response to treatment. {\circledC} 2009 Informa UK Ltd. All rights reserved.",
author = "Irene Meester and Solis-Soto, {Juan Manuel}",
year = "2009",
month = "3",
day = "1",
doi = "10.1517/17530050802708999",
language = "English",
pages = "143--155",
journal = "Expert Opinion on Medical Diagnostics",
issn = "1753-0059",
publisher = "Informa Healthcare",

}

Cytokines: Monitors of disease severity for the clinic. / Meester, Irene; Solis-Soto, Juan Manuel.

In: Expert Opinion on Medical Diagnostics, 01.03.2009, p. 143-155.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Cytokines: Monitors of disease severity for the clinic

AU - Meester, Irene

AU - Solis-Soto, Juan Manuel

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Background: Cytokines communicate between the cells of the immune system and its targets to maintain homeostasis after injury or pathogenic events. They are involved in almost any pathological situation imaginable. Objective: To verify the importance of cytokines as biomarkers in current preclinical (aetiopathogenic, development of new therapies) and clinical studies (diagnosis, disease severity, prognosis and response to therapy). Method/results: A Medline search with the query 'cytokine' AND 'biomarker' AND a variable for a variety of biomedical fields, followed by deeper-level searches, demonstrated the immense popularity of cytokines as biomarkers in almost any biomedical field. Conclusion: As cytokines are not disease-specific they do not serve as single diagnostic biomarkers. The strength of the cytokines resides in monitoring disease severity, prognosis and response to treatment. © 2009 Informa UK Ltd. All rights reserved.

AB - Background: Cytokines communicate between the cells of the immune system and its targets to maintain homeostasis after injury or pathogenic events. They are involved in almost any pathological situation imaginable. Objective: To verify the importance of cytokines as biomarkers in current preclinical (aetiopathogenic, development of new therapies) and clinical studies (diagnosis, disease severity, prognosis and response to therapy). Method/results: A Medline search with the query 'cytokine' AND 'biomarker' AND a variable for a variety of biomedical fields, followed by deeper-level searches, demonstrated the immense popularity of cytokines as biomarkers in almost any biomedical field. Conclusion: As cytokines are not disease-specific they do not serve as single diagnostic biomarkers. The strength of the cytokines resides in monitoring disease severity, prognosis and response to treatment. © 2009 Informa UK Ltd. All rights reserved.

U2 - 10.1517/17530050802708999

DO - 10.1517/17530050802708999

M3 - Literature review

SP - 143

EP - 155

JO - Expert Opinion on Medical Diagnostics

JF - Expert Opinion on Medical Diagnostics

SN - 1753-0059

ER -