Cytokines: Monitors of disease severity for the clinic

Irene Meester, Juan Manuel Solis-Soto

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Background: Cytokines communicate between the cells of the immune system and its targets to maintain homeostasis after injury or pathogenic events. They are involved in almost any pathological situation imaginable. Objective: To verify the importance of cytokines as biomarkers in current preclinical (aetiopathogenic, development of new therapies) and clinical studies (diagnosis, disease severity, prognosis and response to therapy). Method/results: A Medline search with the query 'cytokine' AND 'biomarker' AND a variable for a variety of biomedical fields, followed by deeper-level searches, demonstrated the immense popularity of cytokines as biomarkers in almost any biomedical field. Conclusion: As cytokines are not disease-specific they do not serve as single diagnostic biomarkers. The strength of the cytokines resides in monitoring disease severity, prognosis and response to treatment.

Original languageEnglish
Pages (from-to)143-155
Number of pages13
JournalExpert Opinion on Medical Diagnostics
Issue number2
Publication statusPublished - 1 Mar 2009
Externally publishedYes

Bibliographical note

Copyright 2010 Elsevier B.V., All rights reserved.

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Biomedical Engineering
  • Biochemistry, medical


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