Congenital universal hypertrichosis with deafness and dental anomalies inherited as an X-linked trait

M. Tadin-Strapps, J. C. Salas-Alanis, L. Moreno, D. Warburton, A. Martinez-Mir, Angela M. Christiano

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We report a large Mexican kindred with a variant form of congenital universal hypertrichosis that is inherited in an apparent X-linked recessive manner. In addition to the generalized hypertrichosis, the affected individuals have dental malformations and deafness. Males are more severely affected than females who exhibit only mild hypertrichosis, but not deafness or dental anomalies. Haplotype analysis in this pedigree revealed linkage to a 13-cM region on chromosome Xq24-q27.1 between markers GATA198A10 and DXS8106. Localization of the gene underlying this form of hypertrichosis is the initial step in identifying genes on the X chromosome that are involved in the control of hair growth and development.
Original languageEnglish
Pages (from-to)418-422
Number of pages5
JournalClinical Genetics
DOIs
Publication statusPublished - 1 May 2003
Externally publishedYes

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Hypertrichosis
X-Linked Genes
Deafness
Tooth
Pedigree
Growth and Development
Haplotypes
Chromosomes
Genes

Cite this

Tadin-Strapps, M., Salas-Alanis, J. C., Moreno, L., Warburton, D., Martinez-Mir, A., & Christiano, A. M. (2003). Congenital universal hypertrichosis with deafness and dental anomalies inherited as an X-linked trait. Clinical Genetics, 418-422. https://doi.org/10.1034/j.1399-0004.2003.00069.x
Tadin-Strapps, M. ; Salas-Alanis, J. C. ; Moreno, L. ; Warburton, D. ; Martinez-Mir, A. ; Christiano, Angela M. / Congenital universal hypertrichosis with deafness and dental anomalies inherited as an X-linked trait. In: Clinical Genetics. 2003 ; pp. 418-422.
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Tadin-Strapps, M, Salas-Alanis, JC, Moreno, L, Warburton, D, Martinez-Mir, A & Christiano, AM 2003, 'Congenital universal hypertrichosis with deafness and dental anomalies inherited as an X-linked trait', Clinical Genetics, pp. 418-422. https://doi.org/10.1034/j.1399-0004.2003.00069.x

Congenital universal hypertrichosis with deafness and dental anomalies inherited as an X-linked trait. / Tadin-Strapps, M.; Salas-Alanis, J. C.; Moreno, L.; Warburton, D.; Martinez-Mir, A.; Christiano, Angela M.

In: Clinical Genetics, 01.05.2003, p. 418-422.

Research output: Contribution to journalArticle

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AU - Martinez-Mir, A.

AU - Christiano, Angela M.

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AB - We report a large Mexican kindred with a variant form of congenital universal hypertrichosis that is inherited in an apparent X-linked recessive manner. In addition to the generalized hypertrichosis, the affected individuals have dental malformations and deafness. Males are more severely affected than females who exhibit only mild hypertrichosis, but not deafness or dental anomalies. Haplotype analysis in this pedigree revealed linkage to a 13-cM region on chromosome Xq24-q27.1 between markers GATA198A10 and DXS8106. Localization of the gene underlying this form of hypertrichosis is the initial step in identifying genes on the X chromosome that are involved in the control of hair growth and development.

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Tadin-Strapps M, Salas-Alanis JC, Moreno L, Warburton D, Martinez-Mir A, Christiano AM. Congenital universal hypertrichosis with deafness and dental anomalies inherited as an X-linked trait. Clinical Genetics. 2003 May 1;418-422. https://doi.org/10.1034/j.1399-0004.2003.00069.x