Comparison of positive serology for toxoplasma gondii among patients with ocular toxoplasmosis and other ocular inflammatory diseases

Mónica Gómez Moncada Escalante, Juan Carlos Gutiérrez-Hernández, Manuel Alejando Garza-León, Luz Patricia Navarro-López, Lourdes Arellanes-García

Research output: Contribution to journalArticle

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Abstract

Objective: To determine and compare the seropositivity in patients with clinical diagnosis of ocular toxoplasmosis, as well as in patients with other ocular inflammatory diseases and calculate the sensitivity and specificity of the serological tests in our institution. Material and methods: Retrospective study, transversal, descriptive and observational. Overview of patient records with serology for toxoplasmosis as well as comparison according to its clinical diagnosis and the results of serological titles and finally calculate the sensibility and specificity. Results: Five hundred and six clinical charts were evaluated, a group with the clinical diagnosis of ocular toxoplasmosis (Group 1) which included 132 patients; the group with other ocular inflammation diagnosis (Group 2) included 374 patients, the demographic variables were similar in both groups. In Group 1 the serology for Ig G was positive in 75.8%, in Group 2 in 36.6%. The serology for Ig M was positive in 3% on Group 1 and 2.6% on Group 2. The general sensibility was 0.758 and the specificity was 0.663. Conclusions: There is a clinical-serological correlation in 75% of the patients with ocular toxoplasmosis. The sensibility of the test is high, specially in dilutions of 1:32, the specificity is low at the studied dilutions.
Original languageEnglish
Pages (from-to)20-23
Number of pages4
JournalRevista Mexicana de Oftalmologia
Publication statusPublished - 1 Jan 2008
Externally publishedYes

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Ocular Toxoplasmosis
Eye Diseases
Toxoplasma
Serology
Toxoplasmosis
Serologic Tests
Retrospective Studies
Demography
Inflammation
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Escalante, Mónica Gómez Moncada ; Gutiérrez-Hernández, Juan Carlos ; Garza-León, Manuel Alejando ; Navarro-López, Luz Patricia ; Arellanes-García, Lourdes. / Comparison of positive serology for toxoplasma gondii among patients with ocular toxoplasmosis and other ocular inflammatory diseases. In: Revista Mexicana de Oftalmologia. 2008 ; pp. 20-23.
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Comparison of positive serology for toxoplasma gondii among patients with ocular toxoplasmosis and other ocular inflammatory diseases. / Escalante, Mónica Gómez Moncada; Gutiérrez-Hernández, Juan Carlos; Garza-León, Manuel Alejando; Navarro-López, Luz Patricia; Arellanes-García, Lourdes.

In: Revista Mexicana de Oftalmologia, 01.01.2008, p. 20-23.

Research output: Contribution to journalArticle

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AU - Escalante, Mónica Gómez Moncada

AU - Gutiérrez-Hernández, Juan Carlos

AU - Garza-León, Manuel Alejando

AU - Navarro-López, Luz Patricia

AU - Arellanes-García, Lourdes

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N2 - Objective: To determine and compare the seropositivity in patients with clinical diagnosis of ocular toxoplasmosis, as well as in patients with other ocular inflammatory diseases and calculate the sensitivity and specificity of the serological tests in our institution. Material and methods: Retrospective study, transversal, descriptive and observational. Overview of patient records with serology for toxoplasmosis as well as comparison according to its clinical diagnosis and the results of serological titles and finally calculate the sensibility and specificity. Results: Five hundred and six clinical charts were evaluated, a group with the clinical diagnosis of ocular toxoplasmosis (Group 1) which included 132 patients; the group with other ocular inflammation diagnosis (Group 2) included 374 patients, the demographic variables were similar in both groups. In Group 1 the serology for Ig G was positive in 75.8%, in Group 2 in 36.6%. The serology for Ig M was positive in 3% on Group 1 and 2.6% on Group 2. The general sensibility was 0.758 and the specificity was 0.663. Conclusions: There is a clinical-serological correlation in 75% of the patients with ocular toxoplasmosis. The sensibility of the test is high, specially in dilutions of 1:32, the specificity is low at the studied dilutions.

AB - Objective: To determine and compare the seropositivity in patients with clinical diagnosis of ocular toxoplasmosis, as well as in patients with other ocular inflammatory diseases and calculate the sensitivity and specificity of the serological tests in our institution. Material and methods: Retrospective study, transversal, descriptive and observational. Overview of patient records with serology for toxoplasmosis as well as comparison according to its clinical diagnosis and the results of serological titles and finally calculate the sensibility and specificity. Results: Five hundred and six clinical charts were evaluated, a group with the clinical diagnosis of ocular toxoplasmosis (Group 1) which included 132 patients; the group with other ocular inflammation diagnosis (Group 2) included 374 patients, the demographic variables were similar in both groups. In Group 1 the serology for Ig G was positive in 75.8%, in Group 2 in 36.6%. The serology for Ig M was positive in 3% on Group 1 and 2.6% on Group 2. The general sensibility was 0.758 and the specificity was 0.663. Conclusions: There is a clinical-serological correlation in 75% of the patients with ocular toxoplasmosis. The sensibility of the test is high, specially in dilutions of 1:32, the specificity is low at the studied dilutions.

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