Abstract
Background Gingival lesions in patients with dystrophic epidermolysis bullosa (DEB) are a common manifestation. However, their clinical features, frequency and severity are currently unknown. Methods Forty-five DEB patients were assessed by an oral medicine specialist, who analysed the presence/absence of four clinical signs (erythema, erosion/ulcer, atrophy, blister) on free and attached gingiva, using the Epidermolysis Bullosa Oropharyngeal Severity score. Results Twenty-eight (62.2%) out of 45 DEB patients showed different types of gingival lesions, whose presence/absence and total frequency/distribution were not significantly different between males and females (p = 0.087 and p = 0.091, respectively). Erythema was the most prevalent lesion (66.2%) and the recessive DEB severe generalized (RDEB-sev gen) reached the highest median disease activity score. A significant correlation was observed between the DEB subtypes and the disease activity median score (p < 0.001), but not between age and total disease activity score in each group of DEB (p > 0.05). Lastly, logistic regression showed that only gender (p = 0.031) and RDEB-sev gen (p = 0.001) were risks factors for the presence of gingival lesions. Conclusions Gingival lesions in DEB patients are a relatively common entity and may have multiple clinical aspects, emphasizing the need for thorough attention and awareness among dentists.
| Original language | English |
|---|---|
| Pages (from-to) | 18-23 |
| Number of pages | 6 |
| Journal | Australian Dental Journal |
| Volume | 60 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Mar 2015 |
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Bibliographical note
© 2015 Australian Dental Association.All Science Journal Classification (ASJC) codes
- Dentistry(all)
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Clinical features of gingival lesions in patients with dystrophic epidermolysis bullosa : A cross-sectional study. / Fortuna, G.; Aria, M.; Cepeda-Valdes, R.; Pollio, A.; Moreno-Trevino, M. G.; Salas-Alanís, J. C.
In: Australian Dental Journal, Vol. 60, No. 1, 01.03.2015, p. 18-23.Research output: Contribution to journal › Article
TY - JOUR
T1 - Clinical features of gingival lesions in patients with dystrophic epidermolysis bullosa
T2 - A cross-sectional study
AU - Fortuna, G.
AU - Aria, M.
AU - Cepeda-Valdes, R.
AU - Pollio, A.
AU - Moreno-Trevino, M. G.
AU - Salas-Alanís, J. C.
N1 - © 2015 Australian Dental Association.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Background Gingival lesions in patients with dystrophic epidermolysis bullosa (DEB) are a common manifestation. However, their clinical features, frequency and severity are currently unknown. Methods Forty-five DEB patients were assessed by an oral medicine specialist, who analysed the presence/absence of four clinical signs (erythema, erosion/ulcer, atrophy, blister) on free and attached gingiva, using the Epidermolysis Bullosa Oropharyngeal Severity score. Results Twenty-eight (62.2%) out of 45 DEB patients showed different types of gingival lesions, whose presence/absence and total frequency/distribution were not significantly different between males and females (p = 0.087 and p = 0.091, respectively). Erythema was the most prevalent lesion (66.2%) and the recessive DEB severe generalized (RDEB-sev gen) reached the highest median disease activity score. A significant correlation was observed between the DEB subtypes and the disease activity median score (p < 0.001), but not between age and total disease activity score in each group of DEB (p > 0.05). Lastly, logistic regression showed that only gender (p = 0.031) and RDEB-sev gen (p = 0.001) were risks factors for the presence of gingival lesions. Conclusions Gingival lesions in DEB patients are a relatively common entity and may have multiple clinical aspects, emphasizing the need for thorough attention and awareness among dentists.
AB - Background Gingival lesions in patients with dystrophic epidermolysis bullosa (DEB) are a common manifestation. However, their clinical features, frequency and severity are currently unknown. Methods Forty-five DEB patients were assessed by an oral medicine specialist, who analysed the presence/absence of four clinical signs (erythema, erosion/ulcer, atrophy, blister) on free and attached gingiva, using the Epidermolysis Bullosa Oropharyngeal Severity score. Results Twenty-eight (62.2%) out of 45 DEB patients showed different types of gingival lesions, whose presence/absence and total frequency/distribution were not significantly different between males and females (p = 0.087 and p = 0.091, respectively). Erythema was the most prevalent lesion (66.2%) and the recessive DEB severe generalized (RDEB-sev gen) reached the highest median disease activity score. A significant correlation was observed between the DEB subtypes and the disease activity median score (p < 0.001), but not between age and total disease activity score in each group of DEB (p > 0.05). Lastly, logistic regression showed that only gender (p = 0.031) and RDEB-sev gen (p = 0.001) were risks factors for the presence of gingival lesions. Conclusions Gingival lesions in DEB patients are a relatively common entity and may have multiple clinical aspects, emphasizing the need for thorough attention and awareness among dentists.
UR - http://www.scopus.com/inward/record.url?scp=84923563354&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923563354&partnerID=8YFLogxK
U2 - 10.1111/adj.12264
DO - 10.1111/adj.12264
M3 - Article
C2 - 25721275
AN - SCOPUS:84923563354
VL - 60
SP - 18
EP - 23
JO - Australian Dental Journal
JF - Australian Dental Journal
SN - 0045-0421
IS - 1
ER -