Clinical features of gingival lesions in patients with dystrophic epidermolysis bullosa: A cross-sectional study

G. Fortuna*, M. Aria, R. Cepeda-Valdes, A. Pollio, M. G. Moreno-Trevino, J. C. Salas-Alanís

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background Gingival lesions in patients with dystrophic epidermolysis bullosa (DEB) are a common manifestation. However, their clinical features, frequency and severity are currently unknown. Methods Forty-five DEB patients were assessed by an oral medicine specialist, who analysed the presence/absence of four clinical signs (erythema, erosion/ulcer, atrophy, blister) on free and attached gingiva, using the Epidermolysis Bullosa Oropharyngeal Severity score. Results Twenty-eight (62.2%) out of 45 DEB patients showed different types of gingival lesions, whose presence/absence and total frequency/distribution were not significantly different between males and females (p = 0.087 and p = 0.091, respectively). Erythema was the most prevalent lesion (66.2%) and the recessive DEB severe generalized (RDEB-sev gen) reached the highest median disease activity score. A significant correlation was observed between the DEB subtypes and the disease activity median score (p < 0.001), but not between age and total disease activity score in each group of DEB (p > 0.05). Lastly, logistic regression showed that only gender (p = 0.031) and RDEB-sev gen (p = 0.001) were risks factors for the presence of gingival lesions. Conclusions Gingival lesions in DEB patients are a relatively common entity and may have multiple clinical aspects, emphasizing the need for thorough attention and awareness among dentists.

Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalAustralian Dental Journal
Issue number1
Publication statusPublished - 1 Mar 2015

Bibliographical note

© 2015 Australian Dental Association.

All Science Journal Classification (ASJC) codes

  • General Dentistry


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