Clinical features of gingival lesions in patients with dystrophic epidermolysis bullosa

A cross-sectional study

G. Fortuna, M. Aria, R. Cepeda-Valdes, A. Pollio, M. G. Moreno-Trevino, J. C. Salas-Alanís

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background Gingival lesions in patients with dystrophic epidermolysis bullosa (DEB) are a common manifestation. However, their clinical features, frequency and severity are currently unknown. Methods Forty-five DEB patients were assessed by an oral medicine specialist, who analysed the presence/absence of four clinical signs (erythema, erosion/ulcer, atrophy, blister) on free and attached gingiva, using the Epidermolysis Bullosa Oropharyngeal Severity score. Results Twenty-eight (62.2%) out of 45 DEB patients showed different types of gingival lesions, whose presence/absence and total frequency/distribution were not significantly different between males and females (p = 0.087 and p = 0.091, respectively). Erythema was the most prevalent lesion (66.2%) and the recessive DEB severe generalized (RDEB-sev gen) reached the highest median disease activity score. A significant correlation was observed between the DEB subtypes and the disease activity median score (p < 0.001), but not between age and total disease activity score in each group of DEB (p > 0.05). Lastly, logistic regression showed that only gender (p = 0.031) and RDEB-sev gen (p = 0.001) were risks factors for the presence of gingival lesions. Conclusions Gingival lesions in DEB patients are a relatively common entity and may have multiple clinical aspects, emphasizing the need for thorough attention and awareness among dentists.

Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalAustralian Dental Journal
Volume60
Issue number1
DOIs
Publication statusPublished - 1 Mar 2015

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Epidermolysis Bullosa Dystrophica
Cross-Sectional Studies
Erythema
Epidermolysis Bullosa
Oral Medicine
Gingiva
Blister
Dentists
Ulcer
Atrophy
Logistic Models

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Fortuna, G. ; Aria, M. ; Cepeda-Valdes, R. ; Pollio, A. ; Moreno-Trevino, M. G. ; Salas-Alanís, J. C. / Clinical features of gingival lesions in patients with dystrophic epidermolysis bullosa : A cross-sectional study. In: Australian Dental Journal. 2015 ; Vol. 60, No. 1. pp. 18-23.
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Clinical features of gingival lesions in patients with dystrophic epidermolysis bullosa : A cross-sectional study. / Fortuna, G.; Aria, M.; Cepeda-Valdes, R.; Pollio, A.; Moreno-Trevino, M. G.; Salas-Alanís, J. C.

In: Australian Dental Journal, Vol. 60, No. 1, 01.03.2015, p. 18-23.

Research output: Contribution to journalArticle

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T1 - Clinical features of gingival lesions in patients with dystrophic epidermolysis bullosa

T2 - A cross-sectional study

AU - Fortuna, G.

AU - Aria, M.

AU - Cepeda-Valdes, R.

AU - Pollio, A.

AU - Moreno-Trevino, M. G.

AU - Salas-Alanís, J. C.

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N2 - Background Gingival lesions in patients with dystrophic epidermolysis bullosa (DEB) are a common manifestation. However, their clinical features, frequency and severity are currently unknown. Methods Forty-five DEB patients were assessed by an oral medicine specialist, who analysed the presence/absence of four clinical signs (erythema, erosion/ulcer, atrophy, blister) on free and attached gingiva, using the Epidermolysis Bullosa Oropharyngeal Severity score. Results Twenty-eight (62.2%) out of 45 DEB patients showed different types of gingival lesions, whose presence/absence and total frequency/distribution were not significantly different between males and females (p = 0.087 and p = 0.091, respectively). Erythema was the most prevalent lesion (66.2%) and the recessive DEB severe generalized (RDEB-sev gen) reached the highest median disease activity score. A significant correlation was observed between the DEB subtypes and the disease activity median score (p < 0.001), but not between age and total disease activity score in each group of DEB (p > 0.05). Lastly, logistic regression showed that only gender (p = 0.031) and RDEB-sev gen (p = 0.001) were risks factors for the presence of gingival lesions. Conclusions Gingival lesions in DEB patients are a relatively common entity and may have multiple clinical aspects, emphasizing the need for thorough attention and awareness among dentists.

AB - Background Gingival lesions in patients with dystrophic epidermolysis bullosa (DEB) are a common manifestation. However, their clinical features, frequency and severity are currently unknown. Methods Forty-five DEB patients were assessed by an oral medicine specialist, who analysed the presence/absence of four clinical signs (erythema, erosion/ulcer, atrophy, blister) on free and attached gingiva, using the Epidermolysis Bullosa Oropharyngeal Severity score. Results Twenty-eight (62.2%) out of 45 DEB patients showed different types of gingival lesions, whose presence/absence and total frequency/distribution were not significantly different between males and females (p = 0.087 and p = 0.091, respectively). Erythema was the most prevalent lesion (66.2%) and the recessive DEB severe generalized (RDEB-sev gen) reached the highest median disease activity score. A significant correlation was observed between the DEB subtypes and the disease activity median score (p < 0.001), but not between age and total disease activity score in each group of DEB (p > 0.05). Lastly, logistic regression showed that only gender (p = 0.031) and RDEB-sev gen (p = 0.001) were risks factors for the presence of gingival lesions. Conclusions Gingival lesions in DEB patients are a relatively common entity and may have multiple clinical aspects, emphasizing the need for thorough attention and awareness among dentists.

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