Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum

José Francisco Islas; Adriana Quiroz-Reyes; Paulina Delgado-Gonzalez; Hector Franco-Villareal; Juan Luis Delgado-Gallegos; Elsa N. Garza-Treviño; Carlos Gonzalez-Villarreal

doi:10.3390/cancers14163948

Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum

José Francisco Islas, Adriana Quiroz-Reyes, Paulina Delgado-Gonzalez, Hector Franco-Villareal, Juan Luis Delgado-Gallegos, Elsa N. Garza-Treviño, Carlos Gonzalez-Villarreal

Departamento Académico

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Gastrointestinal adenocarcinomas are one of the world’s deadliest cancers. Cancer stem cells and the tissue microenvironment are highly regulated by cell and molecular mechanisms. Cancer stem cells are essential for maintenance and progression and are associated with resistance to conventional treatments. This article reviews the current knowledge of the role of the microenvironment during the primary establishment of gastrointestinal adenocarcinomas in the stomach, colon, and rectum and its relationship with cancer stem cells. We also describe novel developments in cancer therapeutics, such as targeted therapy, and discuss the advantages and disadvantages of different treatments for improving gastrointestinal cancer prognosis.

Original language	English
Article number	3948
Journal	Cancers
Volume	14
Issue number	16
DOIs	https://doi.org/10.3390/cancers14163948
Publication status	Published - 16 Aug 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors.

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers14163948

Cite this

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title = "Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum",

abstract = "Gastrointestinal adenocarcinomas are one of the world{\textquoteright}s deadliest cancers. Cancer stem cells and the tissue microenvironment are highly regulated by cell and molecular mechanisms. Cancer stem cells are essential for maintenance and progression and are associated with resistance to conventional treatments. This article reviews the current knowledge of the role of the microenvironment during the primary establishment of gastrointestinal adenocarcinomas in the stomach, colon, and rectum and its relationship with cancer stem cells. We also describe novel developments in cancer therapeutics, such as targeted therapy, and discuss the advantages and disadvantages of different treatments for improving gastrointestinal cancer prognosis.",

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T1 - Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum

AU - Francisco Islas, José

AU - Quiroz-Reyes, Adriana

AU - Delgado-Gonzalez, Paulina

AU - Franco-Villareal, Hector

AU - Delgado-Gallegos, Juan Luis

AU - Garza-Treviño, Elsa N.

AU - Gonzalez-Villarreal, Carlos

PY - 2022/8/16

Y1 - 2022/8/16

N2 - Gastrointestinal adenocarcinomas are one of the world’s deadliest cancers. Cancer stem cells and the tissue microenvironment are highly regulated by cell and molecular mechanisms. Cancer stem cells are essential for maintenance and progression and are associated with resistance to conventional treatments. This article reviews the current knowledge of the role of the microenvironment during the primary establishment of gastrointestinal adenocarcinomas in the stomach, colon, and rectum and its relationship with cancer stem cells. We also describe novel developments in cancer therapeutics, such as targeted therapy, and discuss the advantages and disadvantages of different treatments for improving gastrointestinal cancer prognosis.

AB - Gastrointestinal adenocarcinomas are one of the world’s deadliest cancers. Cancer stem cells and the tissue microenvironment are highly regulated by cell and molecular mechanisms. Cancer stem cells are essential for maintenance and progression and are associated with resistance to conventional treatments. This article reviews the current knowledge of the role of the microenvironment during the primary establishment of gastrointestinal adenocarcinomas in the stomach, colon, and rectum and its relationship with cancer stem cells. We also describe novel developments in cancer therapeutics, such as targeted therapy, and discuss the advantages and disadvantages of different treatments for improving gastrointestinal cancer prognosis.

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Cancer Stem Cells in Tumor Microenvironment of Adenocarcinoma of the Stomach, Colon, and Rectum

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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