Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion

C. R. Cámara-Lemarroy, F. J. Guzmán-De La Garza, P. Cordero-Pérez, G. Alarcón-Galván, J. M. Ibarra-Hernández, L. E. Muñoz-Espinosa, N. E. Fernández-Garza

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Intestinal ischemia-reperfusion (I/R) causes severe organ failure and intense inflammatory responses, which are mediated in part by the cytokine tumor necrosis factor-alpha (TNF-alpha). Bupropion is an antidepressant known to inhibit TNF-alpha production. We sought to examine the protective effects of bupropion on intestinal I/R injury in 15 male Sprague-Dawley rats that were randomized to sham surgery, 45 minutes of intestinal ischemia followed by 180 minutes reperfusion, or bupropion (100 mg/kg) before the intestinal I/R injury. To evaluate the systemic inflammatory response induced by intestinal I/R, we measured serum levels of TNF-alpha, interleukins-1 and -6, lipid peroxidation, and transaminases. Histologic analysis evaluated intestinal injury using the Chiu muscosal injury score. After I/R, Chiu score in control animals was 3.6 ± 1.2 vs 2.6 ± 0.53 in animals that received bupropion (P <.05). Bupropion pretreatment reduced intestinal. I/R injury and blunted serum elevations of TNF-alpha (0.96 ± 1.1 ng/mL vs 0.09 ± 0.06 ng/mL, P <.05) and interleukin-1 (0.53 ± 0.24 ng/mL vs 0.2 ± 0.11 ng/mL, P <.05). Bupropion in reduced intestinal I/R injury through immunomodulatory machanisms that involve inflammatory cytokines such as TNF-alpha. © 2013 Elsevier Inc.
Original languageEnglish
Pages (from-to)2502-2505
Number of pages4
JournalTransplantation Proceedings
DOIs
Publication statusPublished - 1 Jul 2013
Externally publishedYes

Fingerprint

Bupropion
Reperfusion
Ischemia
Reperfusion Injury
Tumor Necrosis Factor-alpha
Wounds and Injuries
Interleukin-1
Cytokines
Transaminases
Serum
Antidepressive Agents
Lipid Peroxidation
Sprague Dawley Rats
Interleukin-6

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Cámara-Lemarroy, C. R., Guzmán-De La Garza, F. J., Cordero-Pérez, P., Alarcón-Galván, G., Ibarra-Hernández, J. M., Muñoz-Espinosa, L. E., & Fernández-Garza, N. E. (2013). Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion. Transplantation Proceedings, 2502-2505. https://doi.org/10.1016/j.transproceed.2013.04.010
Cámara-Lemarroy, C. R. ; Guzmán-De La Garza, F. J. ; Cordero-Pérez, P. ; Alarcón-Galván, G. ; Ibarra-Hernández, J. M. ; Muñoz-Espinosa, L. E. ; Fernández-Garza, N. E. / Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion. In: Transplantation Proceedings. 2013 ; pp. 2502-2505.
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Cámara-Lemarroy, CR, Guzmán-De La Garza, FJ, Cordero-Pérez, P, Alarcón-Galván, G, Ibarra-Hernández, JM, Muñoz-Espinosa, LE & Fernández-Garza, NE 2013, 'Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion', Transplantation Proceedings, pp. 2502-2505. https://doi.org/10.1016/j.transproceed.2013.04.010

Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion. / Cámara-Lemarroy, C. R.; Guzmán-De La Garza, F. J.; Cordero-Pérez, P.; Alarcón-Galván, G.; Ibarra-Hernández, J. M.; Muñoz-Espinosa, L. E.; Fernández-Garza, N. E.

In: Transplantation Proceedings, 01.07.2013, p. 2502-2505.

Research output: Contribution to journalArticle

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AU - Cámara-Lemarroy, C. R.

AU - Guzmán-De La Garza, F. J.

AU - Cordero-Pérez, P.

AU - Alarcón-Galván, G.

AU - Ibarra-Hernández, J. M.

AU - Muñoz-Espinosa, L. E.

AU - Fernández-Garza, N. E.

PY - 2013/7/1

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AB - Intestinal ischemia-reperfusion (I/R) causes severe organ failure and intense inflammatory responses, which are mediated in part by the cytokine tumor necrosis factor-alpha (TNF-alpha). Bupropion is an antidepressant known to inhibit TNF-alpha production. We sought to examine the protective effects of bupropion on intestinal I/R injury in 15 male Sprague-Dawley rats that were randomized to sham surgery, 45 minutes of intestinal ischemia followed by 180 minutes reperfusion, or bupropion (100 mg/kg) before the intestinal I/R injury. To evaluate the systemic inflammatory response induced by intestinal I/R, we measured serum levels of TNF-alpha, interleukins-1 and -6, lipid peroxidation, and transaminases. Histologic analysis evaluated intestinal injury using the Chiu muscosal injury score. After I/R, Chiu score in control animals was 3.6 ± 1.2 vs 2.6 ± 0.53 in animals that received bupropion (P <.05). Bupropion pretreatment reduced intestinal. I/R injury and blunted serum elevations of TNF-alpha (0.96 ± 1.1 ng/mL vs 0.09 ± 0.06 ng/mL, P <.05) and interleukin-1 (0.53 ± 0.24 ng/mL vs 0.2 ± 0.11 ng/mL, P <.05). Bupropion in reduced intestinal I/R injury through immunomodulatory machanisms that involve inflammatory cytokines such as TNF-alpha. © 2013 Elsevier Inc.

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Cámara-Lemarroy CR, Guzmán-De La Garza FJ, Cordero-Pérez P, Alarcón-Galván G, Ibarra-Hernández JM, Muñoz-Espinosa LE et al. Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion. Transplantation Proceedings. 2013 Jul 1;2502-2505. https://doi.org/10.1016/j.transproceed.2013.04.010