Bullosis diabeticorum: A neglected bullous dermatosis

Ramya Vangipuram, Tiffany Hinojosa, Daniel J. Lewis, Christopher Downing, Caleb Hixson, Julio César Salas-Alanis, Stephen K. Tyring

Research output: Contribution to journalArticle

Abstract

A 75-year-old African-American man presented with a 3-year history of painless, fluid-filled blisters, for which his primary care physician had treated him with doxycycline, cephalexin, and topical corticosteroids, with no significant improvement. The blisters had ruptured spontaneously and healed with scarring. He denied antecedent trauma. His medical history was remarkable for insulin-dependent type 2 diabetes mellitus, hypertension, hypercholesterolemia, primary cutaneous melanoma status-post excision, and breast cancer status-post mastectomy and chemotherapy. Physical examination revealed nontender bullae, measuring up to 4 cm × 3 cm and containing serous fluid, on the anterior portion of both tibias (Figure 1). The Nikolsky sign was negative. There was no evidence of surrounding inflammation. A biopsy revealed subepidermal bullae formation with sparse inflammatory infiltrate (Figure 2). Direct and indirect immunofluorescence studies were negative for immunoglobulin (Ig) G, IgA, IgM, complement C3, C5b-9, and fibrinogen deposition. Culture of the bullous fluid was negative.

Original languageEnglish
Pages (from-to)77-79
Number of pages3
JournalSkinmed
Volume16
Issue number1
Publication statusPublished - 1 Jan 2018

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Vesiculobullous Skin Diseases
Blister
Complement C5b
Complement Membrane Attack Complex
Cephalexin
Direct Fluorescent Antibody Technique
Complement C3
Doxycycline
Mastectomy
Primary Care Physicians
Indirect Fluorescent Antibody Technique
Hypercholesterolemia
Tibia
Type 1 Diabetes Mellitus
African Americans
Fibrinogen
Immunoglobulin A
Type 2 Diabetes Mellitus
Physical Examination
Cicatrix

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

Cite this

Vangipuram, R., Hinojosa, T., Lewis, D. J., Downing, C., Hixson, C., Salas-Alanis, J. C., & Tyring, S. K. (2018). Bullosis diabeticorum: A neglected bullous dermatosis. Skinmed, 16(1), 77-79.
Vangipuram, Ramya ; Hinojosa, Tiffany ; Lewis, Daniel J. ; Downing, Christopher ; Hixson, Caleb ; Salas-Alanis, Julio César ; Tyring, Stephen K. / Bullosis diabeticorum: A neglected bullous dermatosis. In: Skinmed. 2018 ; Vol. 16, No. 1. pp. 77-79.
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Vangipuram, R, Hinojosa, T, Lewis, DJ, Downing, C, Hixson, C, Salas-Alanis, JC & Tyring, SK 2018, 'Bullosis diabeticorum: A neglected bullous dermatosis', Skinmed, vol. 16, no. 1, pp. 77-79.

Bullosis diabeticorum: A neglected bullous dermatosis. / Vangipuram, Ramya; Hinojosa, Tiffany; Lewis, Daniel J.; Downing, Christopher; Hixson, Caleb; Salas-Alanis, Julio César; Tyring, Stephen K.

In: Skinmed, Vol. 16, No. 1, 01.01.2018, p. 77-79.

Research output: Contribution to journalArticle

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Vangipuram R, Hinojosa T, Lewis DJ, Downing C, Hixson C, Salas-Alanis JC et al. Bullosis diabeticorum: A neglected bullous dermatosis. Skinmed. 2018 Jan 1;16(1):77-79.