Botulinum toxin therapy for treatment of spasticity in multiple sclerosis: review and recommendations of the IAB-Interdisciplinary Working Group for Movement Disorders task force

Dirk Dressler, Roongroj Bhidayasiri, Saeed Bohlega, Abderrahmane Chahidi, Tae Mo Chung, Markus Ebke, L. Jorge Jacinto, Ryuji Kaji, Serdar Koçer, Petr Kanovsky, Federico Micheli, Olga Orlova, Sebastian Paus, Zvezdan Pirtosek, Maja Relja, Raymond L. Rosales, José Alberto Sagástegui-Rodríguez, Paul W. Schoenle, Gholam Ali Shahidi, Sofia TimerbaevaUwe Walter, Fereshte Adib Saberi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Botulinum toxin (BT) therapy is an established treatment of spasticity due to stroke. For multiple sclerosis (MS) spasticity this is not the case. IAB-Interdisciplinary Working Group for Movement Disorders formed a task force to explore the use of BT therapy for treatment of MS spasticity. A formalised PubMed literature search produced 55 publications (3 randomised controlled trials, 3 interventional studies, 11 observational studies, 2 case studies, 35 reviews, 1 guideline) all unanimously favouring the use of BT therapy for MS spasticity. There is no reason to believe that BT should be less effective and safe in MS spasticity than it is in stroke spasticity. Recommendations include an update of the current prevalence of MS spasticity and its clinical features according to classifications used in movement disorders. Immunological data on MS patients already treated should be analysed with respect to frequencies of MS relapses and BT antibody formation. Registration authorities should expand registration of BT therapy for spasticity regardless of its aetiology. MS specialists should consider BT therapy for symptomatic treatment of spasticity.

Original languageEnglish
Pages (from-to)112-120
Number of pages9
JournalJournal of Neurology
Volume264
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Botulinum toxin therapy for treatment of spasticity in multiple sclerosis: review and recommendations of the IAB-Interdisciplinary Working Group for Movement Disorders task force'. Together they form a unique fingerprint.

  • Cite this

    Dressler, D., Bhidayasiri, R., Bohlega, S., Chahidi, A., Chung, T. M., Ebke, M., Jacinto, L. J., Kaji, R., Koçer, S., Kanovsky, P., Micheli, F., Orlova, O., Paus, S., Pirtosek, Z., Relja, M., Rosales, R. L., Sagástegui-Rodríguez, J. A., Schoenle, P. W., Shahidi, G. A., ... Saberi, F. A. (2017). Botulinum toxin therapy for treatment of spasticity in multiple sclerosis: review and recommendations of the IAB-Interdisciplinary Working Group for Movement Disorders task force. Journal of Neurology, 264(1), 112-120. https://doi.org/10.1007/s00415-016-8304-z