TY - JOUR
T1 - Biorecognition Engineering Technologies for Cancer Diagnosis
T2 - A Systematic Literature Review of Non-Conventional and Plausible Sensor Development Methods
AU - Mayoral-Peña, Kalaumari
AU - Peña, Omar Israel González
AU - Clark, Alexia María Orrantia
AU - Flores-Vallejo, Rosario Del Carmen
AU - Oza, Goldie
AU - Sharma, Ashutosh
AU - De Donato, Marcos
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Cancer is the second cause of mortality worldwide. Early diagnosis of this multifactorial disease is challenging, especially in populations with limited access to healthcare services. A vast repertoire of cancer biomarkers has been studied to facilitate early diagnosis; particularly, the use of antibodies against these biomarkers has been of interest to detect them through biorecognition. However, there are certain limitations to this approach. Emerging biorecognition engineering technologies are alternative methods to generate molecules and molecule-based scaffolds with similar properties to those presented by antibodies. Molecularly imprinted polymers, recombinant antibodies, and antibody mimetic molecules are three novel technologies commonly used in scientific studies. This review aimed to present the fundamentals of these technologies and address questions about how they are implemented for cancer detection in recent scientific studies. A systematic analysis of the scientific peer-reviewed literature regarding the use of these technologies on cancer detection was carried out starting from the year 2000 up to 2021 to answer these questions. In total, 131 scientific articles indexed in the Web of Science from the last three years were included in this analysis. The results showed that antibody.
AB - Cancer is the second cause of mortality worldwide. Early diagnosis of this multifactorial disease is challenging, especially in populations with limited access to healthcare services. A vast repertoire of cancer biomarkers has been studied to facilitate early diagnosis; particularly, the use of antibodies against these biomarkers has been of interest to detect them through biorecognition. However, there are certain limitations to this approach. Emerging biorecognition engineering technologies are alternative methods to generate molecules and molecule-based scaffolds with similar properties to those presented by antibodies. Molecularly imprinted polymers, recombinant antibodies, and antibody mimetic molecules are three novel technologies commonly used in scientific studies. This review aimed to present the fundamentals of these technologies and address questions about how they are implemented for cancer detection in recent scientific studies. A systematic analysis of the scientific peer-reviewed literature regarding the use of these technologies on cancer detection was carried out starting from the year 2000 up to 2021 to answer these questions. In total, 131 scientific articles indexed in the Web of Science from the last three years were included in this analysis. The results showed that antibody.
UR - http://www.scopus.com/inward/record.url?scp=85127798536&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85127798536&partnerID=8YFLogxK
U2 - 10.3390/cancers14081867
DO - 10.3390/cancers14081867
M3 - Review article
AN - SCOPUS:85127798536
SN - 2072-6694
VL - 14
JO - Cancers
JF - Cancers
IS - 8
M1 - 1867
ER -
