Biocompatibility of liposomes derived from microbial cells: An assesment towards Nanomedicine applications

Carlos M. Valdemar-Aguilar; Rufino Nava-Mendoza; Angel O. Tinoco-Martinez; Vicente D. Compean-García; Blanca Millan-Chiu; Luz M. Lopez-Marin

doi:10.1109/CONIIN.2016.7498126

Biocompatibility of liposomes derived from microbial cells: An assesment towards Nanomedicine applications

Carlos M. Valdemar-Aguilar, Rufino Nava-Mendoza, Angel O. Tinoco-Martinez, Vicente D. Compean-García, Blanca Millan-Chiu, Luz M. Lopez-Marin^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The emergence of Nanotechnology in Medicine has resulted in the development of a wide set of nanocarriers. One of the most popular approaches in drug delivery is the use of liposomes, which are self-assembled lipid bilayers. Mammalian-derived liposomes are known to be highly biocompatible. However, the toxicity of liposomes prepared with microbial lipids is still to be clarified. Strains from the genus Mycobacterium are able to induce a high immune response in humans, which is known to involve the responses towards the amphipathic lipids they synthesize, and various reports have proposed the use of mycobacterial liposomes as adjuvants and vaccine boosts. In this work, M. fortuitum and M. tuberculosis lipids were used to produce mycobacterial-derived liposomes, and their physical and chemical characterization, as well as biocompatibility vis-à-vis human cells are addressed.

Original language	English
Title of host publication	2016 12th Congreso Internacional de Ingenieria, CONIIN 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781509029112
ISBN (Print)	9781509029112
DOIs	https://doi.org/10.1109/CONIIN.2016.7498126
Publication status	Published - 22 Jun 2016
Externally published	Yes
Event	12th Congreso Internacional de Ingenieria, CONIIN 2016 - 12th International Congress on Engineering, CONIIN 2016 - Santiago de Queretaro, Mexico Duration: 1 May 2016 → 6 May 2016

Publication series

Name	2016 12th Congreso Internacional de Ingenieria, CONIIN 2016

Conference

Conference	12th Congreso Internacional de Ingenieria, CONIIN 2016 - 12th International Congress on Engineering, CONIIN 2016
Country/Territory	Mexico
City	Santiago de Queretaro
Period	1/5/16 → 6/5/16

Bibliographical note

Publisher Copyright:
© 2016 IEEE.

All Science Journal Classification (ASJC) codes

Engineering (miscellaneous)
Food Science
Polymers and Plastics
Ceramics and Composites
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/CONIIN.2016.7498126

Cite this

Valdemar-Aguilar, C. M., Nava-Mendoza, R., Tinoco-Martinez, A. O., Compean-García, V. D., Millan-Chiu, B., & Lopez-Marin, L. M. (2016). Biocompatibility of liposomes derived from microbial cells: An assesment towards Nanomedicine applications. In 2016 12th Congreso Internacional de Ingenieria, CONIIN 2016 Article 7498126 (2016 12th Congreso Internacional de Ingenieria, CONIIN 2016). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CONIIN.2016.7498126

Valdemar-Aguilar, Carlos M. ; Nava-Mendoza, Rufino ; Tinoco-Martinez, Angel O. et al. / Biocompatibility of liposomes derived from microbial cells : An assesment towards Nanomedicine applications. 2016 12th Congreso Internacional de Ingenieria, CONIIN 2016. Institute of Electrical and Electronics Engineers Inc., 2016. (2016 12th Congreso Internacional de Ingenieria, CONIIN 2016).

@inproceedings{08161b4ca61b4e2fab40afc7fa55aafb,

title = "Biocompatibility of liposomes derived from microbial cells: An assesment towards Nanomedicine applications",

abstract = "The emergence of Nanotechnology in Medicine has resulted in the development of a wide set of nanocarriers. One of the most popular approaches in drug delivery is the use of liposomes, which are self-assembled lipid bilayers. Mammalian-derived liposomes are known to be highly biocompatible. However, the toxicity of liposomes prepared with microbial lipids is still to be clarified. Strains from the genus Mycobacterium are able to induce a high immune response in humans, which is known to involve the responses towards the amphipathic lipids they synthesize, and various reports have proposed the use of mycobacterial liposomes as adjuvants and vaccine boosts. In this work, M. fortuitum and M. tuberculosis lipids were used to produce mycobacterial-derived liposomes, and their physical and chemical characterization, as well as biocompatibility vis-{\`a}-vis human cells are addressed.",

author = "Valdemar-Aguilar, {Carlos M.} and Rufino Nava-Mendoza and Tinoco-Martinez, {Angel O.} and Compean-Garc{\'i}a, {Vicente D.} and Blanca Millan-Chiu and Lopez-Marin, {Luz M.}",

note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 12th Congreso Internacional de Ingenieria, CONIIN 2016 - 12th International Congress on Engineering, CONIIN 2016 ; Conference date: 01-05-2016 Through 06-05-2016",

year = "2016",

month = jun,

day = "22",

doi = "10.1109/CONIIN.2016.7498126",

language = "English",

isbn = "9781509029112",

series = "2016 12th Congreso Internacional de Ingenieria, CONIIN 2016",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

booktitle = "2016 12th Congreso Internacional de Ingenieria, CONIIN 2016",

address = "United States",

}

Valdemar-Aguilar, CM, Nava-Mendoza, R, Tinoco-Martinez, AO, Compean-García, VD, Millan-Chiu, B & Lopez-Marin, LM 2016, Biocompatibility of liposomes derived from microbial cells: An assesment towards Nanomedicine applications. in 2016 12th Congreso Internacional de Ingenieria, CONIIN 2016., 7498126, 2016 12th Congreso Internacional de Ingenieria, CONIIN 2016, Institute of Electrical and Electronics Engineers Inc., 12th Congreso Internacional de Ingenieria, CONIIN 2016 - 12th International Congress on Engineering, CONIIN 2016, Santiago de Queretaro, Mexico, 1/5/16. https://doi.org/10.1109/CONIIN.2016.7498126

Biocompatibility of liposomes derived from microbial cells: An assesment towards Nanomedicine applications. / Valdemar-Aguilar, Carlos M.; Nava-Mendoza, Rufino; Tinoco-Martinez, Angel O. et al.
2016 12th Congreso Internacional de Ingenieria, CONIIN 2016. Institute of Electrical and Electronics Engineers Inc., 2016. 7498126 (2016 12th Congreso Internacional de Ingenieria, CONIIN 2016).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Biocompatibility of liposomes derived from microbial cells

T2 - 12th Congreso Internacional de Ingenieria, CONIIN 2016 - 12th International Congress on Engineering, CONIIN 2016

AU - Valdemar-Aguilar, Carlos M.

AU - Nava-Mendoza, Rufino

AU - Tinoco-Martinez, Angel O.

AU - Compean-García, Vicente D.

AU - Millan-Chiu, Blanca

AU - Lopez-Marin, Luz M.

PY - 2016/6/22

Y1 - 2016/6/22

N2 - The emergence of Nanotechnology in Medicine has resulted in the development of a wide set of nanocarriers. One of the most popular approaches in drug delivery is the use of liposomes, which are self-assembled lipid bilayers. Mammalian-derived liposomes are known to be highly biocompatible. However, the toxicity of liposomes prepared with microbial lipids is still to be clarified. Strains from the genus Mycobacterium are able to induce a high immune response in humans, which is known to involve the responses towards the amphipathic lipids they synthesize, and various reports have proposed the use of mycobacterial liposomes as adjuvants and vaccine boosts. In this work, M. fortuitum and M. tuberculosis lipids were used to produce mycobacterial-derived liposomes, and their physical and chemical characterization, as well as biocompatibility vis-à-vis human cells are addressed.

AB - The emergence of Nanotechnology in Medicine has resulted in the development of a wide set of nanocarriers. One of the most popular approaches in drug delivery is the use of liposomes, which are self-assembled lipid bilayers. Mammalian-derived liposomes are known to be highly biocompatible. However, the toxicity of liposomes prepared with microbial lipids is still to be clarified. Strains from the genus Mycobacterium are able to induce a high immune response in humans, which is known to involve the responses towards the amphipathic lipids they synthesize, and various reports have proposed the use of mycobacterial liposomes as adjuvants and vaccine boosts. In this work, M. fortuitum and M. tuberculosis lipids were used to produce mycobacterial-derived liposomes, and their physical and chemical characterization, as well as biocompatibility vis-à-vis human cells are addressed.

UR - http://www.scopus.com/inward/record.url?scp=84981531913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981531913&partnerID=8YFLogxK

U2 - 10.1109/CONIIN.2016.7498126

DO - 10.1109/CONIIN.2016.7498126

M3 - Conference contribution

AN - SCOPUS:84981531913

SN - 9781509029112

T3 - 2016 12th Congreso Internacional de Ingenieria, CONIIN 2016

BT - 2016 12th Congreso Internacional de Ingenieria, CONIIN 2016

PB - Institute of Electrical and Electronics Engineers Inc.

Y2 - 1 May 2016 through 6 May 2016

ER -

Valdemar-Aguilar CM, Nava-Mendoza R, Tinoco-Martinez AO, Compean-García VD, Millan-Chiu B, Lopez-Marin LM. Biocompatibility of liposomes derived from microbial cells: An assesment towards Nanomedicine applications. In 2016 12th Congreso Internacional de Ingenieria, CONIIN 2016. Institute of Electrical and Electronics Engineers Inc. 2016. 7498126. (2016 12th Congreso Internacional de Ingenieria, CONIIN 2016). doi: 10.1109/CONIIN.2016.7498126

Biocompatibility of liposomes derived from microbial cells: An assesment towards Nanomedicine applications

Abstract

Publication series

Conference

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this