Association between vitamin D receptor gene polymorphisms and pulmonary tuberculosis in a Mexican population

Beatriz Silva-Ramírez, Cyntia A. Saenz-Saenz, Leonardo A. Bracho-Vela, Katia Peñuelas-Urquides, Viviana Mata-Tijerina, Brenda L. Escobedo-Guajardo, Nelly R. González-Ríos, Ofelia Vázquez-Monsiváis, Mario Bermúdez de León

Research output: Contribution to journalArticle

Abstract

© 2018 Tuberculosis Association of India Background and aims: The impact of host genetic variation in susceptibility of tuberculosis is well documented. The vitamin D receptor gene (VDR) is a transacting transcription factor which mediates innate immune response by enhancing the expression of several antimicrobial peptides, including cathelicidin. An association between VDR polymorphisms with tuberculosis (TB) has been investigated in different ethnic groups; however there are contradictions and inconsistencies in the results. The aim of this study was to evaluate the association between polymorphisms of functional VDR with the susceptibility to pulmonary tuberculosis in a Mexican population. Methods: A case–control study was performed in, 257 patients with pulmonary tuberculosis and 457 healthy controls recruited from: family medicine clinics of the Mexican Social Security Institute. The VDR gene polymorphisms Fok I (rs 2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) were genotyped by TaqMan assays. Statistical analysis was performed using: Epi Info V-7 and SNP Stats software. Results: No statistically significant associations were observed in genotype and haplotype distribution between BsmI, ApaI and TaqI polymorphisms and disease susceptibility. The CC genotype for the VDR gene FokI was significantly more frequent in patients than in controls (29.6% versus 17.5%, OR = 1.97; 95% CI = 1.37–2.8, PC = 0.0004). Moreover, TT genotype was decreased in patients as compared to the control group (24.1% versus 34.8%, OR = 0.59; 95% CI = 0.42–0.84, PC = 0.004). Conclusion: To our best knowledge, this is the first case-control study that finds an association between CC genotype of FokI SNP in the VDR gene with pulmonary tuberculosis in Mexican patients. However more validation studies should be performed to prove our conclusions.
Original languageEnglish
JournalIndian Journal of Tuberculosis
DOIs
Publication statusPublished - 1 Jan 2018
Externally publishedYes

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Calcitriol Receptors
Pulmonary Tuberculosis
Population
Genes
Genotype
Tuberculosis
Single Nucleotide Polymorphism
Social Security
Validation Studies
Disease Susceptibility
Ethnic Groups
Innate Immunity
Haplotypes
Case-Control Studies
India
Transcription Factors
Software
Medicine
Control Groups

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

Cite this

Silva-Ramírez, B., Saenz-Saenz, C. A., Bracho-Vela, L. A., Peñuelas-Urquides, K., Mata-Tijerina, V., Escobedo-Guajardo, B. L., ... León, M. B. D. (2018). Association between vitamin D receptor gene polymorphisms and pulmonary tuberculosis in a Mexican population. Indian Journal of Tuberculosis. https://doi.org/10.1016/j.ijtb.2018.04.005
Silva-Ramírez, Beatriz ; Saenz-Saenz, Cyntia A. ; Bracho-Vela, Leonardo A. ; Peñuelas-Urquides, Katia ; Mata-Tijerina, Viviana ; Escobedo-Guajardo, Brenda L. ; González-Ríos, Nelly R. ; Vázquez-Monsiváis, Ofelia ; León, Mario Bermúdez de. / Association between vitamin D receptor gene polymorphisms and pulmonary tuberculosis in a Mexican population. In: Indian Journal of Tuberculosis. 2018.
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title = "Association between vitamin D receptor gene polymorphisms and pulmonary tuberculosis in a Mexican population",
abstract = "{\circledC} 2018 Tuberculosis Association of India Background and aims: The impact of host genetic variation in susceptibility of tuberculosis is well documented. The vitamin D receptor gene (VDR) is a transacting transcription factor which mediates innate immune response by enhancing the expression of several antimicrobial peptides, including cathelicidin. An association between VDR polymorphisms with tuberculosis (TB) has been investigated in different ethnic groups; however there are contradictions and inconsistencies in the results. The aim of this study was to evaluate the association between polymorphisms of functional VDR with the susceptibility to pulmonary tuberculosis in a Mexican population. Methods: A case–control study was performed in, 257 patients with pulmonary tuberculosis and 457 healthy controls recruited from: family medicine clinics of the Mexican Social Security Institute. The VDR gene polymorphisms Fok I (rs 2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) were genotyped by TaqMan assays. Statistical analysis was performed using: Epi Info V-7 and SNP Stats software. Results: No statistically significant associations were observed in genotype and haplotype distribution between BsmI, ApaI and TaqI polymorphisms and disease susceptibility. The CC genotype for the VDR gene FokI was significantly more frequent in patients than in controls (29.6{\%} versus 17.5{\%}, OR = 1.97; 95{\%} CI = 1.37–2.8, PC = 0.0004). Moreover, TT genotype was decreased in patients as compared to the control group (24.1{\%} versus 34.8{\%}, OR = 0.59; 95{\%} CI = 0.42–0.84, PC = 0.004). Conclusion: To our best knowledge, this is the first case-control study that finds an association between CC genotype of FokI SNP in the VDR gene with pulmonary tuberculosis in Mexican patients. However more validation studies should be performed to prove our conclusions.",
author = "Beatriz Silva-Ram{\'i}rez and Saenz-Saenz, {Cyntia A.} and Bracho-Vela, {Leonardo A.} and Katia Pe{\~n}uelas-Urquides and Viviana Mata-Tijerina and Escobedo-Guajardo, {Brenda L.} and Gonz{\'a}lez-R{\'i}os, {Nelly R.} and Ofelia V{\'a}zquez-Monsiv{\'a}is and Le{\'o}n, {Mario Berm{\'u}dez de}",
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Silva-Ramírez, B, Saenz-Saenz, CA, Bracho-Vela, LA, Peñuelas-Urquides, K, Mata-Tijerina, V, Escobedo-Guajardo, BL, González-Ríos, NR, Vázquez-Monsiváis, O & León, MBD 2018, 'Association between vitamin D receptor gene polymorphisms and pulmonary tuberculosis in a Mexican population', Indian Journal of Tuberculosis. https://doi.org/10.1016/j.ijtb.2018.04.005

Association between vitamin D receptor gene polymorphisms and pulmonary tuberculosis in a Mexican population. / Silva-Ramírez, Beatriz; Saenz-Saenz, Cyntia A.; Bracho-Vela, Leonardo A.; Peñuelas-Urquides, Katia; Mata-Tijerina, Viviana; Escobedo-Guajardo, Brenda L.; González-Ríos, Nelly R.; Vázquez-Monsiváis, Ofelia; León, Mario Bermúdez de.

In: Indian Journal of Tuberculosis, 01.01.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between vitamin D receptor gene polymorphisms and pulmonary tuberculosis in a Mexican population

AU - Silva-Ramírez, Beatriz

AU - Saenz-Saenz, Cyntia A.

AU - Bracho-Vela, Leonardo A.

AU - Peñuelas-Urquides, Katia

AU - Mata-Tijerina, Viviana

AU - Escobedo-Guajardo, Brenda L.

AU - González-Ríos, Nelly R.

AU - Vázquez-Monsiváis, Ofelia

AU - León, Mario Bermúdez de

PY - 2018/1/1

Y1 - 2018/1/1

N2 - © 2018 Tuberculosis Association of India Background and aims: The impact of host genetic variation in susceptibility of tuberculosis is well documented. The vitamin D receptor gene (VDR) is a transacting transcription factor which mediates innate immune response by enhancing the expression of several antimicrobial peptides, including cathelicidin. An association between VDR polymorphisms with tuberculosis (TB) has been investigated in different ethnic groups; however there are contradictions and inconsistencies in the results. The aim of this study was to evaluate the association between polymorphisms of functional VDR with the susceptibility to pulmonary tuberculosis in a Mexican population. Methods: A case–control study was performed in, 257 patients with pulmonary tuberculosis and 457 healthy controls recruited from: family medicine clinics of the Mexican Social Security Institute. The VDR gene polymorphisms Fok I (rs 2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) were genotyped by TaqMan assays. Statistical analysis was performed using: Epi Info V-7 and SNP Stats software. Results: No statistically significant associations were observed in genotype and haplotype distribution between BsmI, ApaI and TaqI polymorphisms and disease susceptibility. The CC genotype for the VDR gene FokI was significantly more frequent in patients than in controls (29.6% versus 17.5%, OR = 1.97; 95% CI = 1.37–2.8, PC = 0.0004). Moreover, TT genotype was decreased in patients as compared to the control group (24.1% versus 34.8%, OR = 0.59; 95% CI = 0.42–0.84, PC = 0.004). Conclusion: To our best knowledge, this is the first case-control study that finds an association between CC genotype of FokI SNP in the VDR gene with pulmonary tuberculosis in Mexican patients. However more validation studies should be performed to prove our conclusions.

AB - © 2018 Tuberculosis Association of India Background and aims: The impact of host genetic variation in susceptibility of tuberculosis is well documented. The vitamin D receptor gene (VDR) is a transacting transcription factor which mediates innate immune response by enhancing the expression of several antimicrobial peptides, including cathelicidin. An association between VDR polymorphisms with tuberculosis (TB) has been investigated in different ethnic groups; however there are contradictions and inconsistencies in the results. The aim of this study was to evaluate the association between polymorphisms of functional VDR with the susceptibility to pulmonary tuberculosis in a Mexican population. Methods: A case–control study was performed in, 257 patients with pulmonary tuberculosis and 457 healthy controls recruited from: family medicine clinics of the Mexican Social Security Institute. The VDR gene polymorphisms Fok I (rs 2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) were genotyped by TaqMan assays. Statistical analysis was performed using: Epi Info V-7 and SNP Stats software. Results: No statistically significant associations were observed in genotype and haplotype distribution between BsmI, ApaI and TaqI polymorphisms and disease susceptibility. The CC genotype for the VDR gene FokI was significantly more frequent in patients than in controls (29.6% versus 17.5%, OR = 1.97; 95% CI = 1.37–2.8, PC = 0.0004). Moreover, TT genotype was decreased in patients as compared to the control group (24.1% versus 34.8%, OR = 0.59; 95% CI = 0.42–0.84, PC = 0.004). Conclusion: To our best knowledge, this is the first case-control study that finds an association between CC genotype of FokI SNP in the VDR gene with pulmonary tuberculosis in Mexican patients. However more validation studies should be performed to prove our conclusions.

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DO - 10.1016/j.ijtb.2018.04.005

M3 - Article

JO - Indian Journal of Tuberculosis

JF - Indian Journal of Tuberculosis

SN - 0019-5707

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Silva-Ramírez B, Saenz-Saenz CA, Bracho-Vela LA, Peñuelas-Urquides K, Mata-Tijerina V, Escobedo-Guajardo BL et al. Association between vitamin D receptor gene polymorphisms and pulmonary tuberculosis in a Mexican population. Indian Journal of Tuberculosis. 2018 Jan 1. https://doi.org/10.1016/j.ijtb.2018.04.005