Aspects of the narcolepsy-cataplexy syndrome in O/E3-null mutant mice

A. K. De La Herrán-Arita, V. C. Zomosa-Signoret, D. A. Millán-Aldaco, M. Palomero-Rivero, M. Guerra-Crespo, R. Drucker-Colín, R. Vidaltamayo

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Abstract

Orexins (hypocretins) are peptide neurotransmitters produced by a small group of neurons located exclusively in the lateral hypothalamus (LH). Orexins modulate arousal, and as a result, have profound effects on feeding behavior and the sleep-wake cycle. Loss of orexin producing neurons leads to a narcoleptic phenotype, characterized by sudden transitions from vigilance to rapid eye movement (REM) sleep (direct transition to REM, DREM) observed in electroencephalogram (EEG) and electromyogram (EMG) recordings. In this study, we demonstrate that mice lacking the basic helix-loop-helix transcription factor O/E3 (also known as ebf2) have a decrease in orexin-producing cells in the LH, in addition to a severely impaired orexinergic innervation of the pons. These changes in the orexinergic circuit of O/E3-null animals induce a narcoleptic phenotype, similar to the one arising in orexin-deficient and orexin-ataxin-3 mice. Taken together, our results suggest that O/E3 plays a central role during the establishment of a functional orexinergic circuit by controlling the expression of essential hypothalamic neurotransmitter and the correct development of the nerve fibers arising from the hypothalamus. This is the first report regarding the narcolepsy-cataplexy syndrome in O/E3-null mice, which adds the importance of transcription factors in the regulation of neural subpopulations that control the sleep-wake cycle. © 2011 IBRO.
Original languageEnglish
Pages (from-to)134-143
Number of pages10
JournalNeuroscience
DOIs
Publication statusPublished - 2 Jun 2011
Externally publishedYes

Fingerprint

Narcolepsy
Lateral Hypothalamic Area
Sleep
REM Sleep
Neurotransmitter Agents
Basic Helix-Loop-Helix Transcription Factors
Phenotype
Neurons
Pons
Electromyography
Feeding Behavior
Arousal
Nerve Fibers
Hypothalamus
Electroencephalography
Transcription Factors
Peptides
Orexins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

De La Herrán-Arita, A. K., Zomosa-Signoret, V. C., Millán-Aldaco, D. A., Palomero-Rivero, M., Guerra-Crespo, M., Drucker-Colín, R., & Vidaltamayo, R. (2011). Aspects of the narcolepsy-cataplexy syndrome in O/E3-null mutant mice. Neuroscience, 134-143. https://doi.org/10.1016/j.neuroscience.2011.03.029
De La Herrán-Arita, A. K. ; Zomosa-Signoret, V. C. ; Millán-Aldaco, D. A. ; Palomero-Rivero, M. ; Guerra-Crespo, M. ; Drucker-Colín, R. ; Vidaltamayo, R. / Aspects of the narcolepsy-cataplexy syndrome in O/E3-null mutant mice. In: Neuroscience. 2011 ; pp. 134-143.
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De La Herrán-Arita, AK, Zomosa-Signoret, VC, Millán-Aldaco, DA, Palomero-Rivero, M, Guerra-Crespo, M, Drucker-Colín, R & Vidaltamayo, R 2011, 'Aspects of the narcolepsy-cataplexy syndrome in O/E3-null mutant mice', Neuroscience, pp. 134-143. https://doi.org/10.1016/j.neuroscience.2011.03.029

Aspects of the narcolepsy-cataplexy syndrome in O/E3-null mutant mice. / De La Herrán-Arita, A. K.; Zomosa-Signoret, V. C.; Millán-Aldaco, D. A.; Palomero-Rivero, M.; Guerra-Crespo, M.; Drucker-Colín, R.; Vidaltamayo, R.

In: Neuroscience, 02.06.2011, p. 134-143.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Aspects of the narcolepsy-cataplexy syndrome in O/E3-null mutant mice

AU - De La Herrán-Arita, A. K.

AU - Zomosa-Signoret, V. C.

AU - Millán-Aldaco, D. A.

AU - Palomero-Rivero, M.

AU - Guerra-Crespo, M.

AU - Drucker-Colín, R.

AU - Vidaltamayo, R.

PY - 2011/6/2

Y1 - 2011/6/2

N2 - Orexins (hypocretins) are peptide neurotransmitters produced by a small group of neurons located exclusively in the lateral hypothalamus (LH). Orexins modulate arousal, and as a result, have profound effects on feeding behavior and the sleep-wake cycle. Loss of orexin producing neurons leads to a narcoleptic phenotype, characterized by sudden transitions from vigilance to rapid eye movement (REM) sleep (direct transition to REM, DREM) observed in electroencephalogram (EEG) and electromyogram (EMG) recordings. In this study, we demonstrate that mice lacking the basic helix-loop-helix transcription factor O/E3 (also known as ebf2) have a decrease in orexin-producing cells in the LH, in addition to a severely impaired orexinergic innervation of the pons. These changes in the orexinergic circuit of O/E3-null animals induce a narcoleptic phenotype, similar to the one arising in orexin-deficient and orexin-ataxin-3 mice. Taken together, our results suggest that O/E3 plays a central role during the establishment of a functional orexinergic circuit by controlling the expression of essential hypothalamic neurotransmitter and the correct development of the nerve fibers arising from the hypothalamus. This is the first report regarding the narcolepsy-cataplexy syndrome in O/E3-null mice, which adds the importance of transcription factors in the regulation of neural subpopulations that control the sleep-wake cycle. © 2011 IBRO.

AB - Orexins (hypocretins) are peptide neurotransmitters produced by a small group of neurons located exclusively in the lateral hypothalamus (LH). Orexins modulate arousal, and as a result, have profound effects on feeding behavior and the sleep-wake cycle. Loss of orexin producing neurons leads to a narcoleptic phenotype, characterized by sudden transitions from vigilance to rapid eye movement (REM) sleep (direct transition to REM, DREM) observed in electroencephalogram (EEG) and electromyogram (EMG) recordings. In this study, we demonstrate that mice lacking the basic helix-loop-helix transcription factor O/E3 (also known as ebf2) have a decrease in orexin-producing cells in the LH, in addition to a severely impaired orexinergic innervation of the pons. These changes in the orexinergic circuit of O/E3-null animals induce a narcoleptic phenotype, similar to the one arising in orexin-deficient and orexin-ataxin-3 mice. Taken together, our results suggest that O/E3 plays a central role during the establishment of a functional orexinergic circuit by controlling the expression of essential hypothalamic neurotransmitter and the correct development of the nerve fibers arising from the hypothalamus. This is the first report regarding the narcolepsy-cataplexy syndrome in O/E3-null mice, which adds the importance of transcription factors in the regulation of neural subpopulations that control the sleep-wake cycle. © 2011 IBRO.

U2 - 10.1016/j.neuroscience.2011.03.029

DO - 10.1016/j.neuroscience.2011.03.029

M3 - Article

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JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

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De La Herrán-Arita AK, Zomosa-Signoret VC, Millán-Aldaco DA, Palomero-Rivero M, Guerra-Crespo M, Drucker-Colín R et al. Aspects of the narcolepsy-cataplexy syndrome in O/E3-null mutant mice. Neuroscience. 2011 Jun 2;134-143. https://doi.org/10.1016/j.neuroscience.2011.03.029