Application of genomic technologies in clinical pharmacology research

Rafael Baltazar Reyes Leon-Cachon, Jorge Angel Isloro Ascacio-Martinez, Magdalena Gomez-Silva, Everardo Pilieyro-Garza, Jos Gerardo Gonzalez-Gonzalez, Gregory Pogue, Laureano Simôn-Buela, Hugo Alberto Barrera-Saldaea

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Technology is the basis of scientific progress and is an essential component for continued competitiveness in industry. The development of a new drug candidate is a long and expensive process, in which a molecule undergoes several stages of research (both pre-clinical and clinical) before being approved for commercialization. Scientific progress has revolutionized the pharmaceutical industry and reshaped the processes by which new drugs are discovered, investigated, and developed. Currently, the influence of genomic variations in drug metabolism must be better understood to predict an individual's response to a given treatment. Employing genomics tools, an individual's genetic profile may be obtained and used as the basis for prescription of the best treatment option, thus personalizing medicine. In this review, we discuss how current mainstream genomic technologies used in clinical pharmacology research can accelerate the identification of populations that can benefit the most while reducing adverse events. (REV INVES dIN. 2015;67:212-8).
Original languageEnglish
Pages (from-to)212-218
Number of pages7
JournalRevista de Investigacion Clinica
Volume67
Issue number4
Publication statusPublished - 1 Jan 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Leon-Cachon, R. B. R., Ascacio-Martinez, J. A. I., Gomez-Silva, M., Pilieyro-Garza, E., Gonzalez-Gonzalez, J. G., Pogue, G., Simôn-Buela, L., & Barrera-Saldaea, H. A. (2015). Application of genomic technologies in clinical pharmacology research. Revista de Investigacion Clinica, 67(4), 212-218.