Application of genomic technologies in clinical pharmacology research

Rafael Baltazar Reyes Leon-Cachon, Jorge Angel Isloro Ascacio-Martinez, Magdalena Gomez-Silva, Everardo Pilieyro-Garza, Jos Gerardo Gonzalez-Gonzalez, Gregory Pogue, Laureano Simôn-Buela, Hugo Alberto Barrera-Saldaea

Research output: Contribution to journalLiterature review

3 Citations (Scopus)

Abstract

Technology is the basis of scientific progress and is an essential component for continued competitiveness in industry. The development of a new drug candidate is a long and expensive process, in which a molecule undergoes several stages of research (both pre-clinical and clinical) before being approved for commercialization. Scientific progress has revolutionized the pharmaceutical industry and reshaped the processes by which new drugs are discovered, investigated, and developed. Currently, the influence of genomic variations in drug metabolism must be better understood to predict an individual's response to a given treatment. Employing genomics tools, an individual's genetic profile may be obtained and used as the basis for prescription of the best treatment option, thus personalizing medicine. In this review, we discuss how current mainstream genomic technologies used in clinical pharmacology research can accelerate the identification of populations that can benefit the most while reducing adverse events. (REV INVES dIN. 2015;67:212-8).
Original languageEnglish
Pages (from-to)212-218
Number of pages7
JournalRevista de Investigacion Clinica
Publication statusPublished - 1 Jan 2015
Externally publishedYes

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Clinical Pharmacology
Technology
Research
Pharmaceutical Preparations
Precision Medicine
Drug Industry
Genomics
Prescriptions
Industry
Therapeutics
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Leon-Cachon, R. B. R., Ascacio-Martinez, J. A. I., Gomez-Silva, M., Pilieyro-Garza, E., Gonzalez-Gonzalez, J. G., Pogue, G., ... Barrera-Saldaea, H. A. (2015). Application of genomic technologies in clinical pharmacology research. Revista de Investigacion Clinica, 212-218.
Leon-Cachon, Rafael Baltazar Reyes ; Ascacio-Martinez, Jorge Angel Isloro ; Gomez-Silva, Magdalena ; Pilieyro-Garza, Everardo ; Gonzalez-Gonzalez, Jos Gerardo ; Pogue, Gregory ; Simôn-Buela, Laureano ; Barrera-Saldaea, Hugo Alberto. / Application of genomic technologies in clinical pharmacology research. In: Revista de Investigacion Clinica. 2015 ; pp. 212-218.
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Leon-Cachon, RBR, Ascacio-Martinez, JAI, Gomez-Silva, M, Pilieyro-Garza, E, Gonzalez-Gonzalez, JG, Pogue, G, Simôn-Buela, L & Barrera-Saldaea, HA 2015, 'Application of genomic technologies in clinical pharmacology research', Revista de Investigacion Clinica, pp. 212-218.

Application of genomic technologies in clinical pharmacology research. / Leon-Cachon, Rafael Baltazar Reyes; Ascacio-Martinez, Jorge Angel Isloro; Gomez-Silva, Magdalena; Pilieyro-Garza, Everardo; Gonzalez-Gonzalez, Jos Gerardo; Pogue, Gregory; Simôn-Buela, Laureano; Barrera-Saldaea, Hugo Alberto.

In: Revista de Investigacion Clinica, 01.01.2015, p. 212-218.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Application of genomic technologies in clinical pharmacology research

AU - Leon-Cachon, Rafael Baltazar Reyes

AU - Ascacio-Martinez, Jorge Angel Isloro

AU - Gomez-Silva, Magdalena

AU - Pilieyro-Garza, Everardo

AU - Gonzalez-Gonzalez, Jos Gerardo

AU - Pogue, Gregory

AU - Simôn-Buela, Laureano

AU - Barrera-Saldaea, Hugo Alberto

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Technology is the basis of scientific progress and is an essential component for continued competitiveness in industry. The development of a new drug candidate is a long and expensive process, in which a molecule undergoes several stages of research (both pre-clinical and clinical) before being approved for commercialization. Scientific progress has revolutionized the pharmaceutical industry and reshaped the processes by which new drugs are discovered, investigated, and developed. Currently, the influence of genomic variations in drug metabolism must be better understood to predict an individual's response to a given treatment. Employing genomics tools, an individual's genetic profile may be obtained and used as the basis for prescription of the best treatment option, thus personalizing medicine. In this review, we discuss how current mainstream genomic technologies used in clinical pharmacology research can accelerate the identification of populations that can benefit the most while reducing adverse events. (REV INVES dIN. 2015;67:212-8).

AB - Technology is the basis of scientific progress and is an essential component for continued competitiveness in industry. The development of a new drug candidate is a long and expensive process, in which a molecule undergoes several stages of research (both pre-clinical and clinical) before being approved for commercialization. Scientific progress has revolutionized the pharmaceutical industry and reshaped the processes by which new drugs are discovered, investigated, and developed. Currently, the influence of genomic variations in drug metabolism must be better understood to predict an individual's response to a given treatment. Employing genomics tools, an individual's genetic profile may be obtained and used as the basis for prescription of the best treatment option, thus personalizing medicine. In this review, we discuss how current mainstream genomic technologies used in clinical pharmacology research can accelerate the identification of populations that can benefit the most while reducing adverse events. (REV INVES dIN. 2015;67:212-8).

M3 - Literature review

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Leon-Cachon RBR, Ascacio-Martinez JAI, Gomez-Silva M, Pilieyro-Garza E, Gonzalez-Gonzalez JG, Pogue G et al. Application of genomic technologies in clinical pharmacology research. Revista de Investigacion Clinica. 2015 Jan 1;212-218.