Angiogénesis y hemostasia en cáncer colorectal

Translated title of the contribution: Angiogenesis and hemostasis in colorectal cancer

Samuel Agredano-Pérez, Ignacio Mariscal-Ramírez, Carlos Ronquillo-Carreón, Tomas Pineda-Razo, Arnulfo H. Nava-Zavala, Benjamín Rubio-Jurado

Research output: Contribution to journalArticle

Abstract

Worldwide, colorectal cancer is the third cause of death in men and the second cause of death in women, with nearly 1.2 million newly-diagnosed cases and 600,000 estimated deaths. A significant proportion of patients have metastatic disease at diagnosis. Neoangiogenesis is the formation of new blood vessels from those already existing, which play an important role in tumor growth and progression. Factors related to endothelial growth have been identified including vascular endothelial growth factor. Different studies have demonstrated coagulation and fibrinolysis systems activation participation in tumor angiogenic development. Some of these factors are Von Willebrand factor, fibrinogen, type I plasminogen activator inhibitor and receptor, in addition to D-dimer and platelets. Serum concentrations of these proteins are considered to be predictors of treatment response, disease progression and survival. Interaction between tumor cells, angiogenesis and coagulation activation is a positive feedback, and strategies interfering in this relationship, such as the use of chemotherapy in combination with new specifically targeted agents, can prevent or treat cancer. In addition, the role of anticoagulant or antiplatelet agents in the treatment of cancer has not yet been determined.

Original languageSpanish
Pages (from-to)171-174
Number of pages4
JournalGaceta Mexicana de Oncologia
Volume16
Issue number3
DOIs
Publication statusPublished - 1 May 2017

Fingerprint

Hemostasis
Colorectal Neoplasms
Neoplasms
Cause of Death
Plasminogen Inactivators
Platelet Aggregation Inhibitors
von Willebrand Factor
Fibrinolysis
Growth
Combination Drug Therapy
Anticoagulants
Fibrinogen
Vascular Endothelial Growth Factor A
Blood Vessels
Disease Progression
Blood Proteins
Blood Platelets
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Agredano-Pérez, S., Mariscal-Ramírez, I., Ronquillo-Carreón, C., Pineda-Razo, T., Nava-Zavala, A. H., & Rubio-Jurado, B. (2017). Angiogénesis y hemostasia en cáncer colorectal. Gaceta Mexicana de Oncologia, 16(3), 171-174. https://doi.org/10.24875/j.gamo.M17000068
Agredano-Pérez, Samuel ; Mariscal-Ramírez, Ignacio ; Ronquillo-Carreón, Carlos ; Pineda-Razo, Tomas ; Nava-Zavala, Arnulfo H. ; Rubio-Jurado, Benjamín. / Angiogénesis y hemostasia en cáncer colorectal. In: Gaceta Mexicana de Oncologia. 2017 ; Vol. 16, No. 3. pp. 171-174.
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Agredano-Pérez, S, Mariscal-Ramírez, I, Ronquillo-Carreón, C, Pineda-Razo, T, Nava-Zavala, AH & Rubio-Jurado, B 2017, 'Angiogénesis y hemostasia en cáncer colorectal', Gaceta Mexicana de Oncologia, vol. 16, no. 3, pp. 171-174. https://doi.org/10.24875/j.gamo.M17000068

Angiogénesis y hemostasia en cáncer colorectal. / Agredano-Pérez, Samuel; Mariscal-Ramírez, Ignacio; Ronquillo-Carreón, Carlos; Pineda-Razo, Tomas; Nava-Zavala, Arnulfo H.; Rubio-Jurado, Benjamín.

In: Gaceta Mexicana de Oncologia, Vol. 16, No. 3, 01.05.2017, p. 171-174.

Research output: Contribution to journalArticle

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Agredano-Pérez S, Mariscal-Ramírez I, Ronquillo-Carreón C, Pineda-Razo T, Nava-Zavala AH, Rubio-Jurado B. Angiogénesis y hemostasia en cáncer colorectal. Gaceta Mexicana de Oncologia. 2017 May 1;16(3):171-174. https://doi.org/10.24875/j.gamo.M17000068