An overview of Neem (Azadirachta indica) and its potential impact on health

Jose Francisco Islas, Ezeiza Acosta, Zuca G-Buentello, Juan Luis Delgado-Gallegos, María Guadalupe Moreno-Treviño, Bruno Escalante, Jorge E. Moreno-Cuevas*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

88 Citations (Scopus)


Global health and medical practice seek to merge alternative medicine with evidence-based medicine for a better understanding of the metabolic process and its effects in the human body. An example is the use of complementary medicine like phytotherapy. Azadirachta indica (Neem), a tree originally from India and Myanmar, called by many “The village pharmacy” or “Divine tree” because of its many health properties. In recent times, Neem-derived extracts have been shown to work from anywhere from insect repellent, to supplements to lower inflammation, diabetic control, and even to combat cancer. Herein, we state the health benefits found in diverse compounds and extracts derived from Neem, highlighting the mechanisms and pathways in which Neem compounds produce their effects, while warning that the improper and unstandardized conditions to produce extracts can lead to health issues, particularly certain compounds might have damaging effects on the liver and kidneys.

Original languageEnglish
Article number104171
JournalJournal of Functional Foods
Publication statusPublished - Nov 2020

Bibliographical note

Funding Information:
Department of Health Sciences at the Universidad de Monterrey.

Publisher Copyright:
© 2020

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics


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