ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

Rafael B R Leon-Cachon; Mauricio Salinas-Santander; Daniela Alejandra Aguilar-Tamez; Paola Mariana Valdez-Ortiz; Clara Patricia Ríos-Ibarra; Ana Cecilia Cepeda-Nieto; Victor de Jesús Suárez-Valencia; Jesús Antonio Morlett-Chávez

doi:10.32725/jab.2022.017

ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

Rafael B R Leon-Cachon, Mauricio Salinas-Santander, Daniela Alejandra Aguilar-Tamez, Paola Mariana Valdez-Ortiz, Clara Patricia Ríos-Ibarra, Ana Cecilia Cepeda-Nieto, Victor de Jesús Suárez-Valencia, Jesús Antonio Morlett-Chávez

Departamento Académico

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: The ADIPOQ gene encodes a fat-derived protein hormone with a preponderant role in the homeostasis of glucose and fatty acids. However, previous association studies between ADIPOQ genetic variants and metabolic disorders have shown controversial results. In this study, we evaluated the effect of the ADIPOQ-rs2241766 polymorphism on diverse biochemical parameters (i.e., insulin resistance, atherogenic index, overweight and obesity) in an adolescent population from Mexico. Methods: A cross-sectional study with convenience sampling was carried out in 356 adolescents from Northern Mexico. They were classified by sex and BMI-z score. The biochemical parameters were measured from blood samples using conventional methods. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: In low and normal weight groups, GG carriers had a significantly higher cholesterol level (P ≤ 0.05) than TG and TT carriers. However, there was no association between ADIPOQ-rs2241766 polymorphism and atherogenic index, overweight, or obesity. Conclusions: Our findings suggest that the cholesterol levels are under the influence of the ADIPOQ-rs2241766 polymorphism in Mexican adolescents and may explain how ADIPOQ variants increase the risk of developing metabolic disorders. Nevertheless, further studies are required to rule out the influence of other genetic and non-genetic factors.

Original language	English
Pages (from-to)	146-153
Number of pages	8
Journal	Journal of Applied Biomedicine
Volume	20
Issue number	4
DOIs	https://doi.org/10.32725/jab.2022.017
Publication status	Published - 14 Dec 2022

Bibliographical note

Funding Information:
This project was funded by PRODEP “Support for the incor-

Funding Information:
This project was funded by PRODEP “Support for the incor-poration of New PTC” with folio UACOAH-PTC-315 and the Research Department, Faculty of Medicine in Saltillo, Universidad Autónoma de Coahuila; Coahuila, Mexico.

Publisher Copyright:
© 2022 The Authors. Published by University of South Bohemia in České Budějovice, Faculty of Health and Social Sciences.

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Leon-Cachon, R. B. R., Salinas-Santander, M., Aguilar-Tamez, D. A., Valdez-Ortiz, P. M., Ríos-Ibarra, C. P., Cepeda-Nieto, A. C., Suárez-Valencia, V. D. J., & Morlett-Chávez, J. A. (2022). ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents. Journal of Applied Biomedicine, 20(4), 146-153. https://doi.org/10.32725/jab.2022.017

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title = "ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents",

abstract = "Background: The ADIPOQ gene encodes a fat-derived protein hormone with a preponderant role in the homeostasis of glucose and fatty acids. However, previous association studies between ADIPOQ genetic variants and metabolic disorders have shown controversial results. In this study, we evaluated the effect of the ADIPOQ-rs2241766 polymorphism on diverse biochemical parameters (i.e., insulin resistance, atherogenic index, overweight and obesity) in an adolescent population from Mexico. Methods: A cross-sectional study with convenience sampling was carried out in 356 adolescents from Northern Mexico. They were classified by sex and BMI-z score. The biochemical parameters were measured from blood samples using conventional methods. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: In low and normal weight groups, GG carriers had a significantly higher cholesterol level (P ≤ 0.05) than TG and TT carriers. However, there was no association between ADIPOQ-rs2241766 polymorphism and atherogenic index, overweight, or obesity. Conclusions: Our findings suggest that the cholesterol levels are under the influence of the ADIPOQ-rs2241766 polymorphism in Mexican adolescents and may explain how ADIPOQ variants increase the risk of developing metabolic disorders. Nevertheless, further studies are required to rule out the influence of other genetic and non-genetic factors.",

author = "Leon-Cachon, {Rafael B R} and Mauricio Salinas-Santander and Aguilar-Tamez, {Daniela Alejandra} and Valdez-Ortiz, {Paola Mariana} and R{\'i}os-Ibarra, {Clara Patricia} and Cepeda-Nieto, {Ana Cecilia} and Su{\'a}rez-Valencia, {Victor de Jes{\'u}s} and Morlett-Ch{\'a}vez, {Jes{\'u}s Antonio}",

note = "Funding Information: This project was funded by PRODEP “Support for the incor- Funding Information: This project was funded by PRODEP “Support for the incor-poration of New PTC” with folio UACOAH-PTC-315 and the Research Department, Faculty of Medicine in Saltillo, Universidad Aut{\'o}noma de Coahuila; Coahuila, Mexico. Publisher Copyright: {\textcopyright} 2022 The Authors. Published by University of South Bohemia in {\v C}esk{\'e} Bud{\v e}jovice, Faculty of Health and Social Sciences.",

year = "2022",

month = dec,

day = "14",

doi = "10.32725/jab.2022.017",

language = "English",

volume = "20",

pages = "146--153",

journal = "Journal of Applied Biomedicine",

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TY - JOUR

T1 - ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

AU - Leon-Cachon, Rafael B R

AU - Salinas-Santander, Mauricio

AU - Aguilar-Tamez, Daniela Alejandra

AU - Valdez-Ortiz, Paola Mariana

AU - Ríos-Ibarra, Clara Patricia

AU - Cepeda-Nieto, Ana Cecilia

AU - Suárez-Valencia, Victor de Jesús

AU - Morlett-Chávez, Jesús Antonio

N1 - Funding Information: This project was funded by PRODEP “Support for the incor- Funding Information: This project was funded by PRODEP “Support for the incor-poration of New PTC” with folio UACOAH-PTC-315 and the Research Department, Faculty of Medicine in Saltillo, Universidad Autónoma de Coahuila; Coahuila, Mexico. Publisher Copyright: © 2022 The Authors. Published by University of South Bohemia in České Budějovice, Faculty of Health and Social Sciences.

PY - 2022/12/14

Y1 - 2022/12/14

N2 - Background: The ADIPOQ gene encodes a fat-derived protein hormone with a preponderant role in the homeostasis of glucose and fatty acids. However, previous association studies between ADIPOQ genetic variants and metabolic disorders have shown controversial results. In this study, we evaluated the effect of the ADIPOQ-rs2241766 polymorphism on diverse biochemical parameters (i.e., insulin resistance, atherogenic index, overweight and obesity) in an adolescent population from Mexico. Methods: A cross-sectional study with convenience sampling was carried out in 356 adolescents from Northern Mexico. They were classified by sex and BMI-z score. The biochemical parameters were measured from blood samples using conventional methods. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: In low and normal weight groups, GG carriers had a significantly higher cholesterol level (P ≤ 0.05) than TG and TT carriers. However, there was no association between ADIPOQ-rs2241766 polymorphism and atherogenic index, overweight, or obesity. Conclusions: Our findings suggest that the cholesterol levels are under the influence of the ADIPOQ-rs2241766 polymorphism in Mexican adolescents and may explain how ADIPOQ variants increase the risk of developing metabolic disorders. Nevertheless, further studies are required to rule out the influence of other genetic and non-genetic factors.

AB - Background: The ADIPOQ gene encodes a fat-derived protein hormone with a preponderant role in the homeostasis of glucose and fatty acids. However, previous association studies between ADIPOQ genetic variants and metabolic disorders have shown controversial results. In this study, we evaluated the effect of the ADIPOQ-rs2241766 polymorphism on diverse biochemical parameters (i.e., insulin resistance, atherogenic index, overweight and obesity) in an adolescent population from Mexico. Methods: A cross-sectional study with convenience sampling was carried out in 356 adolescents from Northern Mexico. They were classified by sex and BMI-z score. The biochemical parameters were measured from blood samples using conventional methods. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: In low and normal weight groups, GG carriers had a significantly higher cholesterol level (P ≤ 0.05) than TG and TT carriers. However, there was no association between ADIPOQ-rs2241766 polymorphism and atherogenic index, overweight, or obesity. Conclusions: Our findings suggest that the cholesterol levels are under the influence of the ADIPOQ-rs2241766 polymorphism in Mexican adolescents and may explain how ADIPOQ variants increase the risk of developing metabolic disorders. Nevertheless, further studies are required to rule out the influence of other genetic and non-genetic factors.

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U2 - 10.32725/jab.2022.017

DO - 10.32725/jab.2022.017

M3 - Article

SN - 1214-021X

VL - 20

SP - 146

EP - 153

JO - Journal of Applied Biomedicine

JF - Journal of Applied Biomedicine

IS - 4

ER -

ADIPOQ-rs2241766 polymorphism is associated with changes in cholesterol levels of Mexican adolescents

Abstract

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