ACE, APOA5, and MTP Gene Polymorphisms Analysis in Relation to Triglyceride and Insulin Levels in Pediatric Patients

Lilia Carranza-González, Rafael B.R. León-Cachón, María Antonia González-Zavala, Clara Ríos-Ibarra, Jesús Morlett-Chávez, Celia Sánchez-Domínguez, Ana Cepeda-Nieto, Mauricio Salinas-Santander

Research output: Contribution to journalArticle

Abstract

Background and Aims: Obesity is a complex, chronic, and multifactorial disease that has become a major, and worldwide, public health problem contributing to an increased number of pathologies, including type 2 diabetes, cardiovascular disease, hyperlipidemia, and metabolic syndrome, thus suggesting a commolon origin. A diet high in sugar and fats coupled with a sedentary lifestyle has a major role in the development of obesity. However, the genetic background has also been associated with body fat accumulation. The aim of this study was to assess the effect ofACE-rs4646994, APOA5-rs662799, and MTP-rs1800591 gene polymorphisms on clinical and biochemical parameters and to evaluate the association with body phenotypes in children and adolescent population of Saltillo, Coahuila, Mexico. Methods: Anthropometric, clinical, biochemical parameters and BMI were obtained from 405 children and adolescents. The BMI was used to determine the body phenotype. The rs4646994 gene polymorphism was determined by PCR, whereas rs662799 and rs1800591 were determined by PCR-RFLP. The obtained results were analyzed to determine their association of these single nucleotide polymorphisms with body phenotype and biochemical parameters. Results: TT genotype for APOA5-rs662799 was associated with increased levels of HDL-C in the analyzed population (p <0.05). The ACErs4646994gene polymorphism is associated with high Insulin levels, HOMAIR index, and triglyceride levels, mainly when presenting a I/I genotype (p <0.05). Conclusion: The polymorphic allele of the ACE gene is capable of modulating triglyceride levels, insulin levels and HOMA-IR index in the evaluated population; it must be highlighted that this has not been reported in other studied populations elsewhere.

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalArchives of Medical Research
Volume49
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

Fingerprint

Triglycerides
Insulin
Pediatrics
Phenotype
Population
Genes
Obesity
Genotype
Sedentary Lifestyle
Polymerase Chain Reaction
Mexico
Hyperlipidemias
Restriction Fragment Length Polymorphisms
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Adipose Tissue
Chronic Disease
Cardiovascular Diseases
Public Health
Fats

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Carranza-González, L., León-Cachón, R. B. R., González-Zavala, M. A., Ríos-Ibarra, C., Morlett-Chávez, J., Sánchez-Domínguez, C., ... Salinas-Santander, M. (2018). ACE, APOA5, and MTP Gene Polymorphisms Analysis in Relation to Triglyceride and Insulin Levels in Pediatric Patients. Archives of Medical Research, 49(2), 94-100. https://doi.org/10.1016/j.arcmed.2018.04.013
Carranza-González, Lilia ; León-Cachón, Rafael B.R. ; González-Zavala, María Antonia ; Ríos-Ibarra, Clara ; Morlett-Chávez, Jesús ; Sánchez-Domínguez, Celia ; Cepeda-Nieto, Ana ; Salinas-Santander, Mauricio. / ACE, APOA5, and MTP Gene Polymorphisms Analysis in Relation to Triglyceride and Insulin Levels in Pediatric Patients. In: Archives of Medical Research. 2018 ; Vol. 49, No. 2. pp. 94-100.
@article{f0d8e30400944cadba3a4ef229d34c06,
title = "ACE, APOA5, and MTP Gene Polymorphisms Analysis in Relation to Triglyceride and Insulin Levels in Pediatric Patients",
abstract = "Background and Aims: Obesity is a complex, chronic, and multifactorial disease that has become a major, and worldwide, public health problem contributing to an increased number of pathologies, including type 2 diabetes, cardiovascular disease, hyperlipidemia, and metabolic syndrome, thus suggesting a commolon origin. A diet high in sugar and fats coupled with a sedentary lifestyle has a major role in the development of obesity. However, the genetic background has also been associated with body fat accumulation. The aim of this study was to assess the effect ofACE-rs4646994, APOA5-rs662799, and MTP-rs1800591 gene polymorphisms on clinical and biochemical parameters and to evaluate the association with body phenotypes in children and adolescent population of Saltillo, Coahuila, Mexico. Methods: Anthropometric, clinical, biochemical parameters and BMI were obtained from 405 children and adolescents. The BMI was used to determine the body phenotype. The rs4646994 gene polymorphism was determined by PCR, whereas rs662799 and rs1800591 were determined by PCR-RFLP. The obtained results were analyzed to determine their association of these single nucleotide polymorphisms with body phenotype and biochemical parameters. Results: TT genotype for APOA5-rs662799 was associated with increased levels of HDL-C in the analyzed population (p <0.05). The ACErs4646994gene polymorphism is associated with high Insulin levels, HOMAIR index, and triglyceride levels, mainly when presenting a I/I genotype (p <0.05). Conclusion: The polymorphic allele of the ACE gene is capable of modulating triglyceride levels, insulin levels and HOMA-IR index in the evaluated population; it must be highlighted that this has not been reported in other studied populations elsewhere.",
author = "Lilia Carranza-Gonz{\'a}lez and Le{\'o}n-Cach{\'o}n, {Rafael B.R.} and Gonz{\'a}lez-Zavala, {Mar{\'i}a Antonia} and Clara R{\'i}os-Ibarra and Jes{\'u}s Morlett-Ch{\'a}vez and Celia S{\'a}nchez-Dom{\'i}nguez and Ana Cepeda-Nieto and Mauricio Salinas-Santander",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.arcmed.2018.04.013",
language = "English",
volume = "49",
pages = "94--100",
journal = "Archives of Medical Research",
issn = "0188-4409",
publisher = "Elsevier Inc.",
number = "2",

}

Carranza-González, L, León-Cachón, RBR, González-Zavala, MA, Ríos-Ibarra, C, Morlett-Chávez, J, Sánchez-Domínguez, C, Cepeda-Nieto, A & Salinas-Santander, M 2018, 'ACE, APOA5, and MTP Gene Polymorphisms Analysis in Relation to Triglyceride and Insulin Levels in Pediatric Patients', Archives of Medical Research, vol. 49, no. 2, pp. 94-100. https://doi.org/10.1016/j.arcmed.2018.04.013

ACE, APOA5, and MTP Gene Polymorphisms Analysis in Relation to Triglyceride and Insulin Levels in Pediatric Patients. / Carranza-González, Lilia; León-Cachón, Rafael B.R.; González-Zavala, María Antonia; Ríos-Ibarra, Clara; Morlett-Chávez, Jesús; Sánchez-Domínguez, Celia; Cepeda-Nieto, Ana; Salinas-Santander, Mauricio.

In: Archives of Medical Research, Vol. 49, No. 2, 01.02.2018, p. 94-100.

Research output: Contribution to journalArticle

TY - JOUR

T1 - ACE, APOA5, and MTP Gene Polymorphisms Analysis in Relation to Triglyceride and Insulin Levels in Pediatric Patients

AU - Carranza-González, Lilia

AU - León-Cachón, Rafael B.R.

AU - González-Zavala, María Antonia

AU - Ríos-Ibarra, Clara

AU - Morlett-Chávez, Jesús

AU - Sánchez-Domínguez, Celia

AU - Cepeda-Nieto, Ana

AU - Salinas-Santander, Mauricio

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background and Aims: Obesity is a complex, chronic, and multifactorial disease that has become a major, and worldwide, public health problem contributing to an increased number of pathologies, including type 2 diabetes, cardiovascular disease, hyperlipidemia, and metabolic syndrome, thus suggesting a commolon origin. A diet high in sugar and fats coupled with a sedentary lifestyle has a major role in the development of obesity. However, the genetic background has also been associated with body fat accumulation. The aim of this study was to assess the effect ofACE-rs4646994, APOA5-rs662799, and MTP-rs1800591 gene polymorphisms on clinical and biochemical parameters and to evaluate the association with body phenotypes in children and adolescent population of Saltillo, Coahuila, Mexico. Methods: Anthropometric, clinical, biochemical parameters and BMI were obtained from 405 children and adolescents. The BMI was used to determine the body phenotype. The rs4646994 gene polymorphism was determined by PCR, whereas rs662799 and rs1800591 were determined by PCR-RFLP. The obtained results were analyzed to determine their association of these single nucleotide polymorphisms with body phenotype and biochemical parameters. Results: TT genotype for APOA5-rs662799 was associated with increased levels of HDL-C in the analyzed population (p <0.05). The ACErs4646994gene polymorphism is associated with high Insulin levels, HOMAIR index, and triglyceride levels, mainly when presenting a I/I genotype (p <0.05). Conclusion: The polymorphic allele of the ACE gene is capable of modulating triglyceride levels, insulin levels and HOMA-IR index in the evaluated population; it must be highlighted that this has not been reported in other studied populations elsewhere.

AB - Background and Aims: Obesity is a complex, chronic, and multifactorial disease that has become a major, and worldwide, public health problem contributing to an increased number of pathologies, including type 2 diabetes, cardiovascular disease, hyperlipidemia, and metabolic syndrome, thus suggesting a commolon origin. A diet high in sugar and fats coupled with a sedentary lifestyle has a major role in the development of obesity. However, the genetic background has also been associated with body fat accumulation. The aim of this study was to assess the effect ofACE-rs4646994, APOA5-rs662799, and MTP-rs1800591 gene polymorphisms on clinical and biochemical parameters and to evaluate the association with body phenotypes in children and adolescent population of Saltillo, Coahuila, Mexico. Methods: Anthropometric, clinical, biochemical parameters and BMI were obtained from 405 children and adolescents. The BMI was used to determine the body phenotype. The rs4646994 gene polymorphism was determined by PCR, whereas rs662799 and rs1800591 were determined by PCR-RFLP. The obtained results were analyzed to determine their association of these single nucleotide polymorphisms with body phenotype and biochemical parameters. Results: TT genotype for APOA5-rs662799 was associated with increased levels of HDL-C in the analyzed population (p <0.05). The ACErs4646994gene polymorphism is associated with high Insulin levels, HOMAIR index, and triglyceride levels, mainly when presenting a I/I genotype (p <0.05). Conclusion: The polymorphic allele of the ACE gene is capable of modulating triglyceride levels, insulin levels and HOMA-IR index in the evaluated population; it must be highlighted that this has not been reported in other studied populations elsewhere.

UR - http://www.scopus.com/inward/record.url?scp=85046167226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046167226&partnerID=8YFLogxK

U2 - 10.1016/j.arcmed.2018.04.013

DO - 10.1016/j.arcmed.2018.04.013

M3 - Article

VL - 49

SP - 94

EP - 100

JO - Archives of Medical Research

JF - Archives of Medical Research

SN - 0188-4409

IS - 2

ER -